900ha xp support dvd download free

Name: 900ha xp support dvd download free
Category: Free
Published: retrariran1971
Language: English

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

http://alinrafe1983.eklablog.com/expert-spring-mvc-and-web-flow-download-a178428028

 

Compared the ways used to manage partitions, there is no doubt that AOMEI Partition Assistant Standard is the partition magic for Windows 10, because it is much powerful than Disk Management and has no the limitation that trouble you in Disk Management. Therefore, you can download the free software and have a try. How to Manage Disks and Partitions in Windows 10? Windows To Go Creator: install Windows 8/8.1 into external drive. Windows 10 Partition Magic Software - AOMEI Partition Assistant. Resize Partition: change the size of a partition. AOMEI Partition Assistant Standard is a free partition software which can help you completely manage your partition. This software supports Windows 10, Windows 8/8.1, Windows 7/Vista and Windows XP, besides, it supports UEFI/EFI boot and MBR disk, GPT disk including 2TB+.With this software you can extend partition to improve low disk space or merge partitionsto add the free space into the partition which has little space. In this way, you don’t need to worry the problems trouble you before. By AOMEI / Last Updated September 9, 2019. Split Partition: divide a large size partition into two partitions. Migrate OS to SSD or HDD: transfer only operating system to SSD or HDD. Merge Partition: merge two partitions into one. Convert Disk between MBR and GPT: convert disk style from MBR to GPT or GPT to MBR. With the daily increasing data, it has become more and more important for you to manage partitions reasonably in Windows 10. But when it comes to manage partitions, different people have different ideas, but there are commons ways introduced as follows: Free Partition Magic for Windows 10 to Manage Disks and Partitions. Disk Management. In the following picture, you will find Extend Volume grayed out due to there is no unallocated space next to C drive. So the limitation will bring inconvenience for you. In this case, the only way to extend system partition is to delete the partition behind C: drive. Extend Partition: increase the size of the partition you want. Move Partition: change the location of a partition. Disk Management is a built-in tool in Windows 10/8/7 which allows you to create/delete/shrink/extend partition. There are many users who choose this software to manage their partition because it does not require you to download any third-party software. However, there is limitation in this tool. That is when you extending partition with this program, the feature is only available when there is unallocated space adjacent to the drive you want to expand. Make Bootable CD: Create Windows PE bootable media without having to install AIK/WAIK. Main Features: AOMEI Partition Assistant Standard is a free Partition Magic software for Windows 10, which can help you manage your disks and partitions easily and safely. For the users of Windows 10, you may usually come across the problems such as your computer is warned as low disk space, there is little free space in one partition while the other partition has enough free space, or you need to more partitions for storing your different data. In order to solve the problems, you may wonder to know that is there free partition magic for Windows 10 to manage my disks and partitions?

 

 

http://penfontcarmedt1975.eklablog.com/russian-dance-music-top-20-download-a178197228

 

8idx driver download jr

Name: 8idx driver download jr
Category: Downloads
Published: carspsytopdy1989
Language: English

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

http://firanewsxi1982.eklablog.com/81845gvm-rz-drivers-free-download-tv-a179236050

 

Microsoft PowerPoint Viewer is easy to use and allows you to view fully-featured presentations created in PowerPoint 97 and later versions . Microsoft PowerPoint 2010. Allows you to open PowerPoint files for free. If you've received a PowerPoint presentation (in PPT format) but don't have either Microsoft Office or Power Point installed, then don't panic. We have scanned the file and URLs associated with this software program in more than 50 of the world's leading antivirus services; no possible threat has been detected. License. Author's review. This software program is potentially malicious or may contain unwanted bundled software. Microsoft PowerPoint Viewer 2007 for Windows. Add this Program to your website by copying the code below. Why is this software program no longer available in our Catalog? Presentation software gets an update with Microsoft PowerPoint 2016. Microsoft PowerPoint Viewer is a free application that allows you to open (but not edit) PowerPoint files. Why is the software program still available? PowerPoint Viewer 2003 lets you view full-featured presentations created in PowerPoint 97 and later versions. This viewer also supports opening password-protected Microsoft PowerPoint presentations. Microsoft PowerPoint Viewer is all you need to open PowerPoint files without having to go to the expense of installing PowerPoint itself. English Japanese Chinese French Polish Czech Dutch Norwegian Spanish Danish Chinese Russian Italian Finnish German Cn Portuguese Greek Korean Swedish Turkish Arabic Hindi Portuguese. 7 / 10 (2607 votes) Doesn't allow you to edit files. Important note: the trial version for Microsoft Office 2007 is no longer available. Softonic review. Microsoft Excel Viewer. Once you've installed it, all you need to do is browse to the file that you want to open from the file menu. It only opens presentations in full screen mode which is a bit annoying but you can navigate slides by right clicking on the current slide. Microsoft PowerPoint Viewer supports the full range of PowerPoint file extensions including .ppt, . pptx, . pptm, . pot, . potx, . potm, . pps, . ppsx and . ppsm. When you've opened one file, it should automatically open others as the default viewer for PowerPoint files. What is a false positive? Developer. Language. Flag any particular issues you may encounter and Softonic will address those concerns as soon as possible. App specs. Version. Based on our scan system, we have determined that these flags are likely to be real positives. Only opens in full screen mode. It’s highly probable this software program is malicious or contains unwanted bundled software. Embed this Program. Supports all files from PowerPoint 97 onwards. Last month's downloads. Installation takes a while. View Excel Without Installing the Program. It’s extremely likely that this software program is clean. Open PowerPoint PPT files without Powerpoint. Microsoft Office 2007. Microsoft PowerPoint Viewer 2007 is also compatible with: This viewer also supports opening password-protected Microsoft PowerPoint presentations and allows you to print presentations opened in it. Total downloads. What does this mean? Available languages. It means a benign program is wrongfully flagged as malicious due to an overly broad detection signature or algorithm used in an antivirus program. Based on our scan system, we have determined that these flags are possibly false positives . User rating. You may also like. Microsoft PowerPoint 2016. We’d like to highlight that from time to time, we may miss a potentially malicious software program. To continue promising you a malware-free catalog of programs and apps, our team has integrated a Report Software feature in every catalog page that loops your feedback back to us. Important note: Microsoft PowerPoint 2010 is no longer available. In Softonic we scan all the files hosted on our platform to assess and avoid any potential harm for your device. Our team performs checks each time a new file is uploaded and periodically reviews files to confirm or update their status. This comprehensive process allows us to set a status for any downloadable file as follows: Downloads.

 

 

http://aqawevun.eklablog.com/download-sega-mk-3-ultimatum-a179184810

 

945gcm s2c download quotes

Name: 945gcm s2c download quotes
Category: Free
Published: credecrarod1982
Language: English

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

http://nirilecup1979.eklablog.com/download-v-1-02-a178230400

 

BEN BROWN Migraine. Liska D, Lyon M, Jones DS. Detoxification and biotransformational imbalances. Explore (NY). 2006 Mar;2(2):122-40. RESEARCH J. Firth, B. Stubbs, J. Sarris, S. Rosenbaum, S. Teasdale, M. Berk, A. R. Yung. The effects of vitamin and mineral supplementation on symptoms of schizophrenia: a systematic review and meta-analysis . Psychological Medicine , 2017; 1 DOI: 10.1017/S0033291717000022. 34. Yorns WR Jr, Hardison HH. Mitochondrial dysfunction in migraine. Semin Pediatr Neurol. 2013 Sep;20(3):188-93.35. Di Lorenzo C, Pierelli F, Coppola G, Grieco GS, Rengo C, Ciccolella M, Magis D, Bolla M, Casali C, Santorelli FM, Schoenen J. Mitochondrial DNA haplogroups influence the therapeutic response to riboflavin in migraineurs. Neurology. 2009 May 5;72(18):1588-94.36. Cordero MD, Cano-García FJ, Alcocer-Gómez E, De Miguel M, Sánchez-Alcázar JA. Oxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q₁₀ effect on clinical improvement. PLoS One. 2012;7(4):e35677. 37. Borkum JM. Migraine Triggers and Oxidative Stress: A Narrative Review and Synthesis. Headache. 2016 Jan;56(1):12-35. 38. Neri M, Frustaci A, Milic M, Valdiglesias V, Fini M, Bonassi S, Barbanti P. A meta-analysis of biomarkers related to oxidative stress and nitric oxide pathway in migraine. Cephalalgia. 2015 Sep;35(10):931-7.39. Ciancarelli I, Tozzi-Ciancarelli MG, Spacca G, Di Massimo C, Carolei A. Relationship between biofeedback and oxidative stress in patients with chronic migraine. Cephalalgia. 2007 Oct;27(10):1136-41.40. Gonullu H, Gonullu E, Karadas S, Arslan M, Kalemci O, Aycan A, Sayin R, Demir H. The levels of trace elements and heavy metals in patients with acute migraine headache. J Pak Med Assoc. 2015 Jul;65(7):694-7.41. Chen CC, Tsai SS, Yang CY. Association between Fine Particulate Air Pollution and Daily Clinic Visits for Migraine in a Subtropical City: Taipei, Taiwan. Int J Environ Res Public Health. 2015 Apr 29;12(5):4697-708.42. Szyszkowicz M, Rowe BH, Kaplan GG. Ambient sulphur dioxide exposure and emergency department visits for migraine in Vancouver, Canada. Int J Occup Med Environ Health. 2009;22(1):7-12.43. Miller CS. The compelling anomaly of chemical intolerance. Ann N Y Acad Sci. 2001 Mar;933:1-23.44. Katerndahl DA, Bell IR, Palmer RF, Miller CS. Chemical intolerance in primary care settings: prevalence, comorbidity, and outcomes. Ann Fam Med. 2012 Jul-Aug;10(4):357-65. 45. Genuis SJ. Toxic causes of mental illness are overlooked. Neurotoxicology. 2008 Nov;29(6):1147-9. 30. Wiggers GA, Pecanha FM, Briones AM, Perez-Giron JV, Miguel M, et al. (2008) Low mercury concentrations cause oxidative stress and endothelial dysfunction in conductance and resistance arteries. Am J Physiol Heart CircPhysiol 295: 1033-1043. [1] Ménard S, Cerf-Bensussan N, & Heyman M (2010). Multiple facets of intestinal permeability and epithelial handling of dietary antigens. Mucosal immunology, 3 (3), 247-59 PMID: 20404811. 49. Kobal AB, Flisar Z, Miklavcic V, Dizdarević T, Sesek-Briski A (2000) Renal function in miners intermittently exposed to elemental mercury vapour.ArhHigRadaToksikol 51: 369-380. 17, 2005, 271–301. DOI: 10.1017/S095457940505014. Domínguez-Márquez, M., Guna, R., Muñoz, C., Gómez-Muñoz, M., & Borrás, R. (2009). High prevalence of subtype 4 among isolates of Blastocystis hominis from symptomatic patients of a health district of Valencia (Spain) Parasitology Research, 105 (4), 949-955 DOI: 10.1007/s00436-009-1485-y. Effect of luminal growth factor preservation on intestinal growth. Lancet. 1993 Apr 3;341(8849):843-8. View Abstract. Curcumin attenuates severity of premenstrual syndrome symptoms: A randomized, double-blind, placebo-controlled trial. 65. Yorifuji T, Tsuda T, Kashima S, Takao S, Harada M (2010) Long-term exposure to methylmercury and its effects on hypertension in Minamata.Environ Res 110: 40-46. 66. Vupputuri S, Longnecker MP, Daniels JL, Guo X, Sandler DP (2005) Blood mercury level and blood pressure among US women: results from the National Health and Nutrition Examination Survey 1999-2000.Environ Res 97: 195-200. 1 Baştür, A., et al. Efficacy of synbiotic, probiotic, and prebiotic treatments for. Pete A. Williams, Jeffrey M. Harder, Nicole E. Foxworth, Kelly E. Cochran, Vivek M. Philip, Vittorio Porciatti, Oliver Smithies, Simon W. M. John. Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice . Science , 2017; 355 (6326): 756 DOI: 10.1126/science.aal0092. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial. Knapen MH, Braam LA, Drummen NE, Bekers O, Hoeks AP, Vermeer C1. Thromb Haemost. 2015 May;113(5):1135-44. doi: 10.1160/TH14-08-0675. Epub 2015 Feb 19. Eleanor Pullenayegum, PhD et al. Live Attenuated Versus Inactivated Influenza Vaccine in Hutterite Children: A Cluster Randomized Blinded Trial . Annals of Internal Medicine , August 2016 DOI: 10.7326/M16-0513. Jalanka- Tuovinen, J., et al. Intestinal microbiota in healthy adults: Bruno R da Costa, Stephan Reichenbach, Noah Keller, Linda Nartey, Simon Wandel, Peter Jüni, Sven Trelle. Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis. The Lancet, 2016; DOI: 10.1016/S0140-6736(16)30002-2. 23 Juhan, D. Job’s Body: A Handbook for Bodywork. Barrytown; Station Hill Press. Yassine HN, Rawat V, Mack WJ, Quinn JF, Yurko-Mauro K, Bailey-Hall E, Aisen PS, Chui HC, Schneider LS. The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer’s disease. Alzheimers Res Ther. 2016 Jun 30;8:25. PubMed. July 2016. Glyn-Jones S, et al Osteoarthritis. 2015 Mar 3. pii: S0140-6736(14)60802-3. Patrono C, Baigent C. Nonsteroidal anti-inflammatory drugs and the heart. Circulation. 2014 Feb 25;129(8):907-16. Green JA, Hirst-Jones KL, Davidson RK, et al. The potential for dietary factors to prevent or treat osteoarthritis. Proc Nutr Soc. 2014 May;73(2):278-88. Veronese N, Stubbs B, Noale M, Solmi M, Luchini C, Maggi S. Adherence to the Mediterranean diet is associated with better quality of life: data from the Osteoarthritis Initiative. Am J Clin Nutr. 2016 Nov;104(5):1403-1409. Clinton CM, et al. Whole-foods, plant-based diet alleviates the symptoms of osteoarthritis. Arthritis. 2015;2015:708152. Gudbergsen H, et al. Weight loss is effective for symptomatic relief in obese subjects with knee osteoarthritis independently of joint damage severity assessed by high-field MRI and radiography. Osteoarthritis Cartilage. 2012 Jun;20(6):495-502. Riecke BF, et al. Comparing two low-energy diets for the treatment of knee osteoarthritis symptoms in obese patients: a pragmatic randomized clinical trial. Osteoarthritis Cartilage. 2010 Jun;18(6):746-54. DeChristopher LR, Uribarri J, Tucker KL. Intake of high-fructose corn syrup sweetened soft drinks, fruit drinks and apple juice is associated with prevalent arthritis in US adults, aged 20-30 years. Nutr Diabetes. 2016 Mar 7;6:e199. Ghoochani N, Karandish M, Mowla K, Haghighizadeh MH, Jalali MT. The effect of pomegranate juice on clinical signs, matrix metalloproteinases and antioxidant status in patients with knee osteoarthritis. J Sci Food Agric. 2016 Oct;96(13):4377-81. Schumacher HR, Pullman-Mooar S, Gupta SR, Dinnella JE, Kim R, McHugh MP. Randomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee. Osteoarthritis Cartilage. 2013 Aug;21(8):1035-41. Hashempur MH, Sadrneshin S, Mosavat SH, Ashraf A. Green tea (Camellia sinensis) for patients with knee osteoarthritis: A randomized open-label active-controlled clinical trial. Clin Nutr. 2016 Dec 18. Rovati LC, Girolami F, Persiani S. Crystalline glucosamine sulphate in the management of knee osteoarthritis: efficacy, safety, and pharmacokinetic properties. Ther Adv Musculoskelet Dis. 2012 Jun;4(3):167-80. Reginster JY, et al. Role of glucosamine in the treatment for osteoarthritis. Rheumatol Int. 2012 Oct;32(10):2959-67. Salazar J, et al. Glucosamine for osteoarthritis: biological effects, clinical efficacy, and safety on glucose metabolism. Arthritis. 2014;2014:432463 Biggee BA, Blinn CM, McAlindon TE, et al. Low levels of human serum glucosamine after ingestion of glucosamine sulphate relative to capability for peripheral effectiveness. Ann Rheum Dis. 2006 Feb;65(2):222-6. Coulson S, Butt H, Vecchio P, et al. Green-lipped mussel extract (Perna canaliculus) and glucosamine sulphate in patients with knee osteoarthritis: therapeutic efficacy and effects on gastrointestinal microbiota profiles. 2013 Feb;21(1):79-90. Henrotin Y, Marty M, Mobasheri A. What is the current status of chondroitin sulphate and glucosamine for the treatment of knee osteoarthritis? Maturitas. 2014 Jul;78(3):184-7. Singh JA, Noorbaloochi S, MacDonald R, Maxwell LJ. Chondroitin for osteoarthritis. Cochrane Database Syst Rev. 2015 Jan 28;1:CD005614. Zeng C, Wei J, Li H, Wang YL, Xie DX, Yang T, Gao SG, Li YS, Luo W, Lei GH. Effectiveness and safety of Glucosamine, chondroitin, the two in combination, or celecoxib in the treatment of osteoarthritis of the knee. Sci Rep. 2015 Nov 18;5:16827. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulphate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006 Feb 23;354(8):795-808. Usha PR, Naidu MU. Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis. Clin Drug Investig. 2004;24(6):353-63. Debbi EM, et al. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC Complement Altern Med. 2011 Jun 27;11:50. Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical Osteoarthritis Cartilage. 2006 Mar;14(3):286-94. Bagchi D, et al. Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. Int J Clin Pharmacol Res. 2002;22(3-4):101-10. Crowley DC, et al. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int J Med Sci. 2009 Oct 9;6(6):312-21 Abdel-Tawab M, et al. Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data. Clin Pharmacokinet. 2011 Jun;50(6):349-69. Doi Cameron M, Chrubasik S. Oral herbal therapies for treating osteoarthritis. Cochrane Database Syst Rev. 2014 May 22;5:CD002947. Vishal AA, Mishra A, Raychaudhuri SP. A double blind, randomized, placebo controlled clinical study evaluates the early efficacy of aflapin in subjects with osteoarthritis of knee. Int J Med Sci. 2011;8(7):615-22. Sengupta K, et al. Comparative efficacy and tolerability of 5-Loxin and Aflapin Against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci. 2010 Nov 1;7(6):366-77. Henrotin Y, Priem F, Mobasheri A. Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management. Springerplus. 2013 Dec;2(1):56. Perkins K, Sahy W, Beckett RD. Efficacy of Curcuma for Treatment of Osteoarthritis. J Evid Based Complementary Altern Med. 2017 Jan;22(1):156-165. Nakagawa Y, Mukai S, Yamada S, Matsuoka M, Tarumi E, Hashimoto T, Tamura C, Imaizumi A, Nishihira J, Nakamura T. Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study. J Orthop Sci. 2014 Nov;19(6):933-9. Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, Togni S, Appendino G. Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev. 2010 Dec;15(4):337-44. Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, Buntragulpoontawee M, Lukkanapichonchut P, Chootip C, Saengsuwan J, Tantayakom K, Laongpech S. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging. 2014 Mar 20;9:451-8. NUTRIGENOMICS – ANNE PEMBERTON 1. Klinghardt, D. (2013) kryptopyrroluria (Pyroluria) – Lyme Induced Autism. https://www.youtube.com/watch?v=THZhANfFnyY. Antonios Chronopoulos, Benjamin Robinson, Muge Sarper, Ernesto Cortes, Vera Auernheimer, Dariusz Lachowski, Simon Attwood, Rebeca García, Saba Ghassemi, Ben Fabry, Armando del Río Hernández. ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion . Nature Communications , 2016; 7: 12630 DOI: 10.1038/ncomms12630. Giles Major et al. Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-related Symptoms in Individuals with Irritable Bowel Syndrome, Gastroenterology (2016). DOI: 10.1053/j.gastro.2016.09.062. Turmeric tea study: Dias, I., Ademowo, O., Newey, E. and Griffiths, H. (2015). The Nrf2-ARE activation protect neurones against oxidative stress. Free Radical Biology and Medicine, 86, pp.S30-S31. Hawkey, C. (2001). COX-1 and COX-2 inhibitors. Best Practice & Research Clinical Gastroenterology, 15(5), pp.801-820. Lee, J. (2005). Nrf2, a multi-organ protector? The FASEB Journal, 19(9), pp.1061-1066. Aggarwal B.B, Ichikawa H., Garodia P., Weerasinghe P., Sethi G., Bhatt I.D., Pandey M.K., Shishodia S., Nair M.G. From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer. Expert Opin Ther Targets 2006;10(1):87-118. Aggarwal B.B., Sundaram C., Malani N., Ichikawa H. Curcumin: the Indian solid gold. Adv Exp Med Biol. 2007;595:1-75. Aggarwal B.B., Yuan W., Li S., Gupta S.C. Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric. Mol Nutr Food Res. 2013;57(9):1529-42. Potential role of herbal remedies in stem cell therapy: proliferation and differentiation of human mesenchymal stromal cells. Vindya Lankika Udalamaththa, Chanika Dilumi Jayasinghe and Preethi Vidya Udagama. Stem Cell Research & Therapy2016,7:110. DOI: 10.1186/s13287-016-0366-4. AGEING Deirdre A. Robertson, Rose Anne Kenny. Negative perceptions of ageing modify the association between frailty and cognitive function in older adults. Personality and Individual Differences, 2015; DOI: 10.1016/j.paid.2015.12.010. A. Lopez, B. M. Miller, F. Rivera-Chavez, E. M. Velazquez, M. X. Byndloss, A. Chavez-Arroyo, K. L. Lokken, R. M. Tsolis, S. E. Winter, A. J. Baumler. Virulence factors enhance Citrobacter rodentium expansion through aerobic respiration . Science , 2016; 353 (6305): 1249 DOI: 10.1126/science.aag3042. Maret G Traber, Eunice Mah, Scott W Leonard, Gerd Bobe, Richard S Bruno. Metabolic syndrome increases dietary α-tocopherol requirements as assessed using urinary and plasma vitamin E catabolites: a double-blind, crossover clinical trial . The American Journal of Clinical Nutrition , 2017; ajcn138495 DOI: 10.3945/ajcn.116.138495. Pepper, J., & Rosenfeld, S. (2012). The emerging medical ecology of the human gut microbiome Trends in Ecology & Evolution, 27 (7), 381-384 DOI: 10.1016/j.tree.2012.03.002. “Adding fluoride to water supply may have no benefit, say experts”. Haroon Siddique. The Guardian, Friday 25 December 2015: http://www.theguardian.com/society/2015/dec/25/fluoride-water-supply-benefit-unproved-tooth-decay. M. Schwarzer, K. Makki, G. Storelli, I. Machuca-Gayet, D. Srutkova, P. Hermanova, M. E. Martino, S. Balmand, T. Hudcovic, A. Heddi, J. Rieusset, H. Kozakova, H. Vidal, F. Leulier. Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition. Science, 2016; 351 (6275): 854 DOI: 10.1126/science.aad8588. Associated references: Lactobacillus plantarum promotes Drosophila systemic growth by modulating hormonal signals through TOR-dependent nutrient sensing, Gilles Storelli, Arnaud Defaye, Berra Erkosar, Pascal Hols, Julien Royet, François Leulier, Cell Metabolism (2011) 14(3):403-414; and Pathogen Virulence Impedes Mutualist-Mediated Enhancement of Host Juvenile Growth via Inhibition of Protein Digestion. Berra Erkosar, Gilles Storelli, Mélanie Mitchell, Loan Bozonnet, Noémie Bozonnet, François Leulier. Cell Host and Microbe (2015) 18(4):445-55. Ana Isabel Ribeiro, Elias Teixeira Krainski, Marilia Sá Carvalho, Maria de Fátima de Pina. Where do people live longer and shorter lives? An ecological study of old-age survival across 4404 small areas from 18 European countries. Journal of Epidemiology and Community Health, 2016; jech-2015-206827 DOI: 10.1136/jech-2015-206827 . Cynthia Owsley, Gerald McGwin, Mark E. Clark, Gregory R. Jackson, Michael A. Callahan, Lanning B. Kline, C. Douglas Witherspoon, Christine A. Curcio. Delayed Rod-Mediated Dark Adaptation Is a Functional Biomarker for Incident Early Age-Related Macular Degeneration. Ophthalmology, 2016; 123 (2): 344 DOI: 10.1016/j.ophtha.2015.09.041. Line Pedersen et al. Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution. Cell Metabolism, February 2016 DOI: 10.1016/j.cmet.2016.01.011 Anil K. Singh, Sadiq Umar, Sharayah Riegsecker, Mukesh Chourasia, Salahuddin Ahmed. Regulation of Transforming Growth Factor β-Activated Kinase Activation by Epigallocatechin-3-Gallate in Rheumatoid Arthritis Synovial Fibroblasts: Suppression of K63-Linked Autoubiquitination of Tumor Necrosis Factor Receptor-Associated Factor 6. Arthritis & Rheumatology, 2016; 68 (2): 347 DOI: 10.1002/art.39447. Silk, D.B., et al. Clinical trial: The effects of a transgalactooligosaccharide. 46. Wojciechowski J, Kowalski W (1975) Cardiac and aortic lesions in chronic experimental poisoning with mercury vapors.Pol Med SciHist Bull 15: 255-260. [7] Maes M, Kubera M, Leunis JC. The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression. Neuro Endocrinol Lett. 2008 Feb;29(1):117-24. View Abstract. NEWSGenotype, B-vitamin status, and androgens affect space flight–induced ophthalmic changes. January 2016 The FASEB Journal vol. 30 no. 1 141-148. Sara R. Zwart* et al. [15] Favre, L., Spertini, F. & Corthesy, B. Secretory IgA possesses intrinsic modulatory properties stimulating mucosal and systemic immune responses. J. Immunol. 175, 2793–2800 (2005). View Abstract. 16. Minich DM, Bland JS. Dietary management of the metabolic syndrome beyond macronutrients. Nutr Rev. 2008 Aug;66(8):429-44. Stephen P. Juraschek, Allan C. Gelber, Hyon K. Choi, Lawrence J. Appel, Edgar R. Miller. Effects of the Dietary Approaches To Stop Hypertension (DASH) Diet and Sodium Intake on Serum Uric Acid . Arthritis & Rheumatology , 2016; DOI: 10.1002/art.39813. 51. Burr ML, Fehily AM, Gilbert JF, Rogers S, Holliday RM, et al. (1989) Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART).Lancet 2: 757-761. PHE/RIPL website: https://www.gov.uk/government/collections/rare-and-imported-pathogens-laboratory-ripl 2. Stevenson B. Variable VlsE Is Critical for Host Reinfection by the Lyme Disease Spirochete. PLoS One . 2013, 8(4) 3. Meriläinen L et al. Morphological and biochemical features of Borrelia burgdorferi pleomorphic forms. Microbiology. 2015 Mar;161(Pt 3):516-27. 4. Sapi E et al. Characterization of Biofilm Formation by Borrelia burgdorferi In Vitro. PLoS One. 2013 7(10) 5. Cook MJ and Puri BP. Commercial test kits for detection of Lyme borreliosis: a meta-analysis of test accuracy. Int J Gen Med. 2016, Nov 18;9:427-440 6. Stricker RB et al. Lyme disease: the promise of Big Data, companion diagnostics and precision medicine. Infect Drug Resist. 2016;9:215-219 7. Lehman PV et al. Unique Strengths of ELISPOT for T Cell Diagnostics. In: Kalyuzhny AE. Handbook of ELISPOT: Methods and Protocols, Methods in Molecular Biology, Vol. 792. 2nd Ed: Springer; 2012: 3-23. 8. Stricker RB and Winger EE. Decreased CD57 Lymphocyte Subset in Patients with Chronic Lyme Disease. Immunology Letters, 2001;76, 43-48. Shiran Salomon-Zimri, Micaela Johanna Glat, Yael Barhum, Ishai Luz, Anat Boehm-Cagan, Ori Liraz, Tali Ben-Zur, Daniel Offen, Daniel M. Michaelson. Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment . Journal of Alzheimer’s Disease , Volume 53, Number 4, 2016; Pages 1443-1458. Council for Ev >ADAPTATION – CHRIS NEWBOLD. 12. Huang CL, Chang HW, Chang JB, Chen JH, Lin JD, Wu CZ, Pei D, Hung YJ, Lee CH, Chen YL, Hsieh CH. Normal fasting plasma glucose predicts type 2 diabetes and cardiovascular disease in elderly population in Taiwan. QJM. 2016 Aug;109(8):515-22.13. Hsiao FC, Hsieh CH, Wu CZ, Hsu CH, Lin JD, Lee TI, Pei D, Chen YL. Elevated fasting glucose levels within normal range are associated with an increased risk of metabolic syndrome in older women. Eur J Intern Med. 2013 Jul;24(5):425-9.14. Feinman RD, Pogozelski WK, Astrup A, Bernstein RK, Fine EJ, Westman EC, Accurso A, Frassetto L, Gower BA, McFarlane SI, Nielsen JV, Krarup T, Saslow L, Roth KS, Vernon MC, Volek JS, Wilshire GB, Dahlqvist A, Sundberg R, Childers A, Morrison K, Manninen AH, Dashti HM, Wood RJ, Wortman J, Worm N. Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base. Nutrition. 2015 Jan;31(1):1-13. PLoS One. 2016 Oct 31;11(10):e0165378. doi: 10.1371/journal.pone.0165378. eCollection 2016. Third Exposure to a Reduced Carbohydrate Meal Lowers Evening Postprandial Insulin and GIP Responses and HOMA-IR Estimate of Insulin Resistance. Lin PJ 1 , Borer KT 1 . Heather F. Smith, William Parker, Sanet H. Kotzé, Michel Laurin. Morphological evolution of the mammalian cecum and cecal appendix . Comptes Rendus Palevol , 2017; 16 (1): 39 DOI: 10.1016/j.crpv.2016.06.001. Zilversmit, D. B. (1979) Atherogenesis: a postprandial phenomenon. Circulation 60:473-485. 79. Choi AL, Weihe P, Budtz-Jørgensen E, Jørgensen PJ, Salonen JT, et al. (2009) Methylmercury exposure and adverse cardiovascular effects in Faroese whaling men.Environ Health Perspect 117: 367-372. Res (Phila) 7(8):813-823. Kensler TW , et al . (2013) Keap1-nrf2 signaling: a target for cancer prevention by. August 2016. Zanwar, V.G., et al. Symptomatic improvement with gluten restriction in irritable bowel syndrome: a prospective, randomized, double blinded placebo controlled. Bobak Heydari, et al. Effect of Omega-3 Acid Ethyl Esters on Left Ventricular Remodeling After Acute Myocardial InfarctionClinical Perspective . Circulation , 2016; 134 (5): 378 DOI: 10.1161/CIRCULATIONAHA.115.019949. 42. Salonen JT, Malin R, Tuomainen TP, Nyyssönen K, Lakka TA, et al. (1999) Polymorphism in high density lipoprotein paraoxonase gene and risk of acute myocardial infarction in men: prospective nested case-control study.BMJ 319: 487-489. Trovato A, et al. Redox modulation of cellular stress response and lipoxin A4 expression by Coriolus versicolor in rat brain: Relevance to Alzheimer’s disease pathogenesis. Neurotoxicology. 2015 Oct 1. pii: S0161-813X(15)00165-5. doi: 10.1016/j.neuro.2015.09.012. (epub version). Recent Pat Inflamm Allergy Drug Discov. 2012 Jan;6(1):78-87. Efficacy of Yun Zhi (Coriolus versicolor) on survival in cancer patients: systematic review and meta-analysis. Eliza WL1, Fai CK, Chung LP. Evaluation of a functional medicine approach to treating fatigue, stress, and digestive issues in women. Susanne M. Cutshall, Larry R. Bergstrom, Daniel J. Kalish. Complementary Therapies in Clinical Practice, May 2016, Volume 23, Pages 75–81. DOI: http://dx.doi.org/10.1016/j.ctcp.2016.03.005. Buffington et al. Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring. Cell, 2016 DOI: 10.1016/j.cell.2016.06.001 IHCANchat Guess, et al. A randomised controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes. Nutrition & Metabolism 2015 Oct; 12: 36. 71. Mozaffarian D, Shi P, Morris JS, Spiegelman D, Grandjean P, et al. (2011) Mercury exposure and risk of cardiovascular disease in two U.S. cohorts. N Engl J Med 364: 1116-1125. 57. Mazerik JN, Hagele T, Sherwani S, Ciapala V, Butler S, et al. (2007) Phospholipase A2 activation regulates cytotoxicity of methylmercury in vascular endothelial cells.Int J Toxicol 26: 553-569. O’Keefe JH, Bell Postprandial hyperglycemia/hyperlipidemia (postprandial dysmetabolism) is a cardiovascular risk factor. Am J Cardiol. 2007;100(5):899–904. J Med Food. 2016 May 20. [Epub ahead of print] doi: 10.1089/jmf.2016.0030. Inhibition of TNF-α, IL-1α, and IL-1β by Pretreatment of Human Monocyte-Derived Macrophages with Menaquinone-7 and Cell Activation with TLR Agonists In Vitro. Pan MH, Maresz K5, Lee PS4, Wu JC4, Ho CT6, Popko J7,8, Mehta DS9, Stohs SJ10, Badmaev V. 9 Weir. Autism, schizophrenia and other disorders may have roots in life’s earliest stages. Monitor on Psychology February 2012, Vol 43, No. 2. February 2017. Clinical research evidence of cupping therapy in China: a systematic literature review. 68. Virtanen JK, Rissanen TH, Voutilainen S, Tuomainen TP (2007) Mercury as a risk factor for cardiovascular diseases.J NutrBiochem 18: 75-85. BMC Complementary and Alternative Medicine The official journal of the International Society for Complementary Medicine Research (ISCMR)2010 10 :70. Toledo, E., Salas-Salvado, J., Donat-Vargas, C., Buil-Cosiales, P., Estruch, R., Ros, E., Corella, D., Fito, M., Hu, F. B., Aros, F., Gomez-Gracia, E., Romaguera, D., Ortega-Calvo, M., Serra-Majem, L., Pinto, X., Schroder, H., Basora, J., Sorli, J. V., Bullo, M., Serra-Mir, M. & Martinez-Gonzalez, M. A. (2015) Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial: A Randomized Clinical Trial. JAMA Intern Med, 175(11) pp. 1752-60. Neuropsychopharmacology, May 2011. Lei Yin, Kevin Yu, Simon Lin, Xiao Song, Xiaozhong Yu. Associations of blood mercury, inorganic mercury, methyl mercury and bisphenol A with dental surface restorations in the U.S. population, NHANES 2003–2004 and 2010–2012 . Ecotoxicology and Environmental Safety , 2016; 134: 213 DOI: 10.1016/j.ecoenv.2016.09.001. Zamora-Ros, M. Rabassa, A. Cherubini, M. Urpi-Sarda, S. Bandinelli, L. Ferrucci, C. Andres-Lacueva. High Concentrations of a Urinary Biomarker of Polyphenol Intake Are Associated with Decreased Mortality in Older Adults . Journal of Nutrition , 2013; 143 (9): 1445 DOI: 10.3945/jn.113.177121. Ramalho-Santos J and Amaral S. Mol Cell Endocrinol. 2013 Oct 15;379(1-2):74-84. Strushkevich N, et al. Proc Natl Acad Sci USA. 2011 Jun 21;108(25):10139-43. Le B, et al. Andrology. 2014 May 12. [Epub ahead of print.] Psarra AG, et al. IUBMB Life. April 2008. 60(4):210-23. Wickramasekera NT and Das GM. Mitochondrion. 2014 May;16C:26-37. Vasconsuelo A, et al. Steroids. 2011 Nov;76(12):1223-31.Gigli I and Bussmann LE. Life Sciences. 2001;68(13):1505-14. Gigli I and Bussmann LE. Life Sciences. 2001;68(13):1505-14. Klinge CM. Journal of Cellular Biochemistry. 2008;105(6):1342-51. Kulinsky VI and LS Kolesnichenko. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. June 2007;1(2):95-113. Sharpe MA, et al. J Toxicol. 2013;2013:159810. Vasconsuelo A, et al. Ageing Res Rev. 2013 Sep;12(4):907-17. Amaral S, et al. Front Biosci (Schol Ed). 2013 Jan 1;5:181-97. Amaral S and Ramalho-Santos J. Curr Aging Sci. 2009 Dec;2(3):165-73. Irwin RW, et al. Endocrinology. 2008 Jun;149(6):3167-75. Hara Y, et al. Proc Natl Acad Sci USA. 2014 Jan 7;111(1):486-91. Federica Cioffia, et al. Molecular and Cellular Endocrinology. 15 October 2013;379(1-2):51-61. Harper ME and Seifert EL. Thyroid. 2008 Feb;18(2):145-56. Soboll S. Biochim Biophys Acta. 1993;1144:1-16. Golgi F, et al. J Mol Endocrinol. 1994;13:275-82. Hsieh YC, et al. FASEB J. 2006;20:1109-17. LaBarge S, et al. FASEB J. 2014 Mar;28(3):1082-97. Cavalcanti-de-Albuquerque JP, et al. J Appl Physiol (1985). 2014 Apr 1;116(7):779-89. George A and Henkel R. Andrologia. 2014 Jan 6. [Epub ahead of print.] Licznerska BE, et al. Eur J Nutr. 2013 Aug;52(5):1483-92. Sandhir R, et al. Neurochem Int. 2014 Apr 26;74C:16-23. Malgorzata Dobosz-Bartoszek, Mark H. Pinkerton, Zbyszek Otwinowski, Srinivas Chakravarthy, Dieter Söll, Paul R. Copeland, Miljan Simonović. Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation . Nature Communications , 2016; 7: 12941 DOI: 10.1038/ncomms12941. Marc A. Mitchell, David D. Wartinger. Validation of a Functional Pyelocalyceal Renal Model for the Evaluation of Renal Calculi Passage While Riding a Roller Coaster . The Journal of the American Osteopathic Association , 2016; 116 (10): 647 DOI: 10.7556/jaoa.2016.128. Nahin RL, Barnes PM, Stussman BJ. Expenditures on complementary health approaches: United States, 2012. (433KB PDF) National Health Statistics Reports . Hyattsville, MD: National Center for Health Statistics. 2016. 13 Meyer JH et al. Elevated monoamine oxidase a levels in the brain: an Explanation for the monoamine imbalance of major depression. Arch Gen Psychiatry. 2006; 63(11):1209-1216. 1. Younger DS. Epidemiology of Migraine. Neurol Clin. 2016 Nov;34(4):849-861. Harri Hemil�. Vitamin E and the risk of pneumonia: using the I²-statistic to quantify heterogeneity within a controlled trial. British Journal of Nutrition, 2016; 1 DOI: 10.1017/S0007114516003408. [8] Macpherson, A.J., McCoy, K.D., Johansen, F.E. & Brandtzaeg, P. The immune geography of IgA induction and function. Mucosal Immunol. 1, 11–22 (2008). View Abstract. sensitivity in the Netherlands. Nutrients. 2016 Nov; 8(11):714. Julia H. Kreznar, Mark P. Keller, Lindsay L. Traeger, Mary E. Rabaglia, Kathryn L. Schueler, Donald S. Stapleton, Wen Zhao, Eugenio I. Vivas, Brian S. Yandell, Aimee Teo Broman, Bruno Hagenbuch, Alan D. Attie, Federico E. Rey. Host Genotype and Gut Microbiome Modulate Insulin Secretion and Diet-Induced Metabolic Phenotypes . Cell Reports , 2017; 18 (7): 1739 DOI: 10.1016/j.celrep.2017.01.062. 70. Virtanen JK, Laukkanen JA, Mursu J, Voutilainen S, Tuomainen TP (2012) Serum long-chain n-3 polyunsaturated fatty acids, mercury, and risk of sudden cardiac death in men: a prospective population-based study.PLoS One 7: e41046. 59. Peltz A, Sherwani SI, Kotha SR, Mazerik JN, O’Connor Butler ES, et al. (2009) Calcium and calmodulin regulate mercury-induced phospholipase D activation in vascular endothelial cells.Int J Toxicol 28: 190-206. Sarkar et al. Psychobiotics and the Manipulation of Bacteria-Brain Signals . Trends in Neurosciences , October 2016 DOI: 10.1016/j.tins.2016.09.002. Agatha A. van der Klaauw, Julia M. Keogh, Elana Henning, Cheryl Stephenson, Sarah Kelway, Victoria M. Trowse, Naresh Subramanian, Stephen O’Rahilly, Paul C. Fletcher, I. Sadaf Farooqi. Divergent effects of central melanocortin signalling on fat and sucrose preference in humans . Nature Communications , 2016; 7: 13055 DOI: 10.1038/NCOMMS13055. [16] Nose K, Yang H, Sun X, Nose S, Koga H, Feng Y, Miyasaka E, Teitelbaum DH. Glutamine prevents total parenteral nutrition-associated changes to intraepithelial lymphocyte phenotype and function: a potential mechanism for the preservation of epithelial barrier function. J Interferon Cytokine Res. 2010 Feb;30(2):67-80. View Abstract. Martineau AR et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ 2017; 356 doi: https://doi.org/10.1136/bmj.i6583. Ibrahim F, Halttunen T, Tahvonen R, Salminen S. 2006. Probiotic bacteria as potential detoxification tools: assessing their heavy metal binding isotherms. J. Microbiol. 52:877–885. 10.1139/w06-043. 39. Kishimoto T, Oguri T, Abe M, Kajitani H, Tada M (1995) Inhibitory effect of methylmercury on migration and tube formation by cultured human vascular endothelial cells.Arch Toxicol 69: 357-361. Min Wei, Sebastian Brandhorst, Mahshid Shelehchi, Hamed Mirzaei, Chia Wei Cheng, Julia Budniak, Susan Groshen, Wendy J. Mack, Esra Guen, Stefano Di Biase, Pinchas Cohen, Todd E. Morgan, Tanya Dorff, Kurt Hong, Andreas Michalsen, Alessandro Laviano, Valter D. Longo. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease . Science Translational Medicine , 2017; 9 (377): eaai8700 DOI: 10.1126/scitranslmed.aai8700. WELCOME Ann Intern Med. 2005 Feb 15;142(4):260-73 (doi: 10.7326/0003-4819-142-4-200502150-00008). Systematic review: the relationship between clinical experience and quality of health care. Choudhry NK1, Fletcher RH, Soumerai SB. 16 Genetics Home Reference. COMT. 2007. Available at: http://ghr.nlm.nih.gov/gene/COMT. sulforaphane. Top Curr Chem 329:163-177. Clin Pharmacol. 2014 Feb 3;6:19-34. doi: 10.2147/CPAA.S35078. eCollection 2014. 6. Guo LY, Cai XF, Lee JJ, Kang SS, Shin EM, Zhou HY, Jung JW, Kim YS. Comparison of suppressive effects of demethoxycurcumin and bisdemethoxycurcumin on expressions of inflammatory mediators in vitro and in vivo. Arch Pharm Res. 2008 Apr;31(4):490-6. Influence of apple polyphenols on inflammatory gene expression. Jung M, Triebel S, Anke T, Richling E, Erkel G. Mol Nutr Food Res. 2009 Oct;53(10):1263-80. doi: 10.1002/mnfr.200800575. May 2016. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. M. H. J. Knapen, N. E. Drummen, E. Smit, C. Vermeer, E. Theuwissen . Osteoporosis International September 2013, Volume 24, Issue 9, pp 2499-2507. First online: 23 March 2013. Bond DS, Roth J, Nash JM, Wing RR. Migraine and obesity: epidemiology, possible mechanisms and the potential role of weight loss treatment.Obes Rev. 2011;12:e362–71. Verrotti A, Agostinelli S, D’Egidio C, Di Fonzo A, Carotenuto M, Parisi P, Esposito M, Tozzi E, Belcastro V, Mohn A, Battistella PA. Impact of a weight loss program on migraine in obese adolescents. Eur J Neurol. 2013 Feb;20(2):394-7. 1. Juby AG, Hanly MG, Lukaczer D. Clinical challenges in thyroid disease: Time for a new approach? Maturitas. 2016 May;87:72-8. 2. Sategna-Guidetti C, et al. Prevalence of thyroid disorders in untreated adult celiac disease patients and effect of gluten withdrawal: an Italian multicenter study. Am J Gastroenterol. 2001 Mar;96(3):751-7. 3. Karbownik-Lewińska M, Kokoszko-Bilska A. Oxidative damage to macromolecules in the thyroid – experimental evidence. Thyroid Res. 2012 Dec 27;5(1):25. 4. Mancini A, et al. Thyroid Hormones, Oxidative Stress, and Inflammation. Mediators Inflamm. 2016;2016:6757154. 5. Chen A, Kim SS, Chung E, Dietrich KN. Thyroid hormones in relation to lead, mercury, and cadmium exposure in the National Health and Nutrition Examination Survey, 2007-2008. Environ Health Perspect. 2013 Feb;121(2):181-6. 6. Fortunato RS, Ferreira AC, Hecht F, Dupuy C, Carvalho DP. Sexual dimorphism and thyroid dysfunction: a matter of oxidative stress? J Endocrinol. 2014 Apr 22;221(2):R31-40. 7. Vita R, Lapa D, Vita G, Trimarchi F, Benvenga S. A patient with stress-related onset and exacerbations of Graves disease. Nat Clin Pract Endocrinol Metab. 2009 Jan;5(1):55-61. 8. The Lancet Diabetes Endocrinology. Iodine deficiency in the UK: grabbing the low-hanging fruit. Lancet Diabetes Endocrinol. 2016 Jun;4(6):469. 9. Zimmermann MB, Boelaert K. Iodine deficiency and thyroid disorders. Lancet Diabetes Endocrinol. 2015 Apr;3(4):286-95. 10. Kahaly G, Dienes HP, Beyer J, Hommel G. Randomized, double blind, placebo-controlled trial of low dose iodide in endemic goiter. J Clin Endocrinol Metab. 1997 Dec;82(12):4049-53. 11. Herter-Aeberli I, et al. Iodine Supplementation Decreases Hypercholesterolemia in Iodine-Deficient, Overweight Women: A Randomized Controlled Trial. J Nutr. 2015 Sep;145(9):2067-75. 12. Farhangi MA, Keshavarz SA, Eshraghian M, Ostadrahimi A, Saboor-Yaraghi AA. The effect of vitamin A supplementation on thyroid function in premenopausal women. J Am Coll Nutr. 2012 Aug;31(4):268-74. 13. Duntas LH, Papanastasiou L, Mantzou E, Koutras DA. Incidence of sideropenia and effects of iron repletion treatment in women with subclinical hypothyroidism. Exp Clin Endocrinol Diabetes. 1999;107(6):356-60. 14. Kandhro GA, Kazi TG, Afridi HI, Kazi N, Baig JA, Arain MB, Sirajuddin, Shah AQ, Sarfraz RA, Jamali MK, Syed N. Effect of zinc supplementation on the zinc level in serum and urine and their relation to thyroid hormone profile in male and female goitrous patients. Clin Nutr. 2009 Apr;28(2):162-8. 15. Toulis KA, Anastasilakis AD, Tzellos TG, Goulis DG, Kouvelas D. Selenium supplementation in the treatment of Hashimoto’s thyroiditis: a systematic review and a meta-analysis. Thyroid. 2010 Oct;20(10):1163-73. 16. Palinkas LA, Reedy KR, Smith M, Anghel M, Steel GD, Reeves D, Shurtleff D, Case HS, Van Do N, Reed HL. Psychoneuroendocrine effects of combined thyroxine and triiodothyronine versus tyrosine during prolonged Antarctic residence. Int J Circumpolar Health. 2007 Dec;66(5):401-17. 17. Felker P, Bunch R, Leung AM. Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism. Nutr Rev. 2016 Apr;74(4):248-58. 18. Sathyapalan T, Manuchehri AM, Thatcher NJ, Rigby AS, Chapman T, Kilpatrick ES, Atkin SL. The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: a randomized, double-blind, crossover study. J Clin Endocrinol Metab. 2011 May;96(5):1442-9. 19. Messina M, Redmond G. Effects of soy protein and soybean isoflavones on thyroid function in healthy adults and hypothyroid patients: a review of the relevant literature. Thyroid. 2006 Mar;16(3):249-58. 20. Peckham S, Lowery D, Spencer S. Are fluoride levels in drinking water associated with hypothyroidism prevalence in England? A large observational study of GP practice data and fluoride levels in drinking water. J Epidemiol Community Health. 2015 Jul;69(7):619-24. 21. Chandra AK, Goswami H, Sengupta P. Dietary calcium induced cytological and biochemical changes in thyroid. Environ Toxicol Pharmacol. 2012 Sep;34(2):454-65. 22. Wang N, Zhou Y, Fu C, Wang H, Huang P, Wang B, Su M, Jiang F, Fang H, Zhao Q, Chen Y, Jiang Q. Influence of Bisphenol A on Thyroid Volume and Structure Independent of Iodine in School Children. PLoS One. 2015 Oct 23;10(10):e0141248. 23. Pelletier C, Doucet E, Imbeault P, Tremblay A. Associations between weight loss-induced changes in plasma organochlorine concentrations, serum T(3) concentration, and resting metabolic rate. Toxicol Sci. 2002 May;67(1):46-51. 24. Di Matola T, Zeppa P, Gasperi M, Vitale M. Thyroid dysfunction following a kelp-containing marketed diet. BMJ Case Rep. 2014 Oct 29;2014. 25. Sategna-Guidetti C, et al. Prevalence of thyroid disorders in untreated adult celiac disease patients and effect of gluten withdrawal: an Italian multicenter study. Am J Gastroenterol. 2001 Mar;96(3):751-7. Shanafelt, Tait D. et al. Mayo Clinic Proceedings 2016, Volume 90 , Issue 12 , 1600-13. Harri Hemil. Vitamin E and the risk of pneumonia: using the I²-statistic to quantify heterogeneity within a controlled trial. British Journal of Nutrition, 2016; 1 DOI: 10.1017/S0007114516003408. Zaidi et al. Vitamin D Deficiency in Medical Inpatients: A Retrospective Study of Implications of Untreated Versus Treated Deficiency. Nutrition and Metabolic Insights 2016:9 65–69 doi:10.4137/NMI.S33747. 4 Osmo A. Wiio (1978). Wiion lait – ja vähän muidenkin (Wiio’s laws – and some others). Weilin+Göös. Adrian Raine, Rose A. Cheney, Ringo Ho, Jill Portnoy, Jianghong Liu, Liana Soyfer, Joseph Hibbeln, Therese S. Richmond. Nutritional supplementation to reduce child aggression: a randomized, stratified, single-blind, factorial trial. Journal of Child Psychology and Psychiatry, 2016; DOI: 10.1111/jcpp.12565 Adrian Raine, Jill Portnoy, Jianghong Liu, Tashneem Mahoomed, Joseph R. Hibbeln. Reduction in behavior problems with omega-3 supplementation in children aged 8-16 years: a randomized, double-blind, placebo-controlled, stratified, parallel-group trial. Journal of Child Psychology and Psychiatry, 2015; 56 (5): 509 DOI: 10.1111/jcpp.12314. [13] Rook GA, Brunet LR. Microbes, immunoregulation, and the gut. Gut. 2005 Mar;54(3):317-20. Review. View Full Paper. Isabel Garcia-Perez, Joram M Posma, Rachel Gibson, Edward S Chambers, Tue H Hansen, Henrik Vestergaard, Torben Hansen, Manfred Beckmann, Oluf Pedersen, Paul Elliott, Jeremiah Stamler, Jeremy K Nicholson, John Draper, John C Mathers, Elaine Holmes, Gary Frost. Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial . The Lancet Diabetes & Endocrinology , 2017; DOI: 10.1016/S2213-8587(16)30419-3. IHCAN AUGUST references. * The January 2015 Duke University study, “Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial,” was published in the Journal of Policy Analysis and Management. *Benedicte Meyer et al, Maintenance of Chronic Fatigue Syndrome (CFS) in Young CFS Patients Is Associated with the 5-HTTLPR and SNP rs25531 A > G Genotype. PLOS One, 2015, http://dx.doi.org/10.1371/journal.pone.0140883. GLUTEN and AUTO-IMMUNITY. Rai, V. (2016) Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism and Alzheimer Disease Risk: a Meta-Analysis. Mol Neurobiol, pp. 4 Abdulamir HA1, Abdul-Rasheed OF, Abdulghani EA. “Low oxytocin and melatonin levels and their possible role in the diagnosis and prognosis in Iraqi autistic children.“Saudi Med J. 2016 Jan;37(1):29-36. doi: 10.15537/smj.2016.1.13183. Cherrie L. Small, Lydia Xing, Joseph B. McPhee, Hong T. Law, Brian K. Coombes. Acute Infectious Gastroenteritis Potentiates a Crohn’s Disease Pathobiont to Fuel Ongoing Inflammation in the Post-Infectious Period. PLOS Pathogens, 2016; 12 (10): e1005907 DOI: 10.1371/journal.ppat.1005907. [19] Parcell S. Sulfur in human nutrition and applications in medicine. Altern Med Rev. 2002 Feb;7(1):22-44. Review. View Paper. 63. Bautista LE, Stein JH, Morgan BJ, Stanton N, Young T, et al. (2009) Association of blood and hair mercury with blood pressure and vascular reactivity.WMJ 108: 250-252. Adrian R Martineau, Christopher J Cates, Mitsuyoshi Urashima, Megan Jensen, Alex P Griffiths, Ulugbek Nurmatov, Aziz Sheikh, Chris J Griffiths. Vitamin D for the management of asthma . Cochrane Library , 2016 DOI: 10.1002/14651858.CD011511.pub2 . DOI: 10.1186/1472-6882-10-70. Journal of Traditional Chinese Medical Sciences. Tominaga M, Eguchi H, Manaka H, Igarashi K, Kato T, Sekikawa A. Impaired glucose tolerance is a risk factor for cardiovascular disease, but not impaired fasting glucose. The Funagata Diabetes Study. Diabetes Care 1999;22:920 –924. Mellen PB, Bittner V, Herrington DM. Post-challenge glucose predicts coronary atherosclerotic progression in non-diabetic, post-menopausal women. Diabet Med. 2007;24(10):1156-1159. [1] OED Online. Oxford University Press, September 2016. Fowler, A. K., Hewetson, A., Agrawal, R. G., Dagda, M., Dagda, R., Moaddel, R., Balbo, S., Sanghvi, M., Chen, Y., Hogue, R. J., Bergeson, S. E., Henderson, G. I. & Kruman, Ii (2012) Alcohol-induced one-carbon metabolism impairment promotes dysfunction of DNA base excision repair in adult brain. J Biol Chem, 287(52) pp. 43533-42. DeAngelis YM, Gemmer CM, Kaczvinsky, JR, Kenneally DC, Schwartz JR, Dawson Jr TL (2005) Three etiologic facets of dandruff and seborrheic dermatitis: malassezia fungi, sebaceous lipids and individual Journal of Investigative Dermatology Symposium Proceedings, Elmira Akbari, Zatollah Asemi, Reza Daneshvar Kakhaki, Fereshteh Bahmani, Ebrahim Kouchaki, Omid Reza Tamtaji, Gholam Ali Hamidi, Mahmoud Salami. Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer’s Disease: A Randomized, Double-Blind and Controlled Trial . Frontiers in Aging Neuroscience , 2016; 8 DOI: 10.3389/fnagi.2016.00256. 3. Lipton RB, Bigal ME, Diamond M, Freitag F, Reed ML, Stewart WF; AMPP Advisory Group.. Migraine prevalence, disease burden, and the need for preventive therapy. Neurology. 2007 Jan 30;68(5):343-9.4. Bigal M, Krymchantowski AV, Lipton RB. Barriers to satisfactory migraine outcomes. What have we learned, where do we stand? Headache. 2009 Jul;49(7):1028-41.5. Sun-Edelstein C, Rapoport AM. Update on the Pharmacological Treatment of Chronic Migraine. Curr Pain Headache Rep. 2016 Jan;20(1):6.6. Peck KR, Johnson YL, Smitherman TA. Migraine. Handb Clin Neurol. 2016;138:283-93. 7. Carod-Artal FJ. Tackling chronic migraine: current perspectives. J Pain Res. 2014 Apr 8;7:185-94.8. May A, Schulte LH. Chronic migraine: risk factors, mechanisms and treatment. Nat Rev Neurol. 2016 Aug;12(8):455-64.9. Buture A, Gooriah R, Nimeri R, Ahmed F. Current Understanding on Pain Mechanism in Migraine and Cluster Headache. Anesth Pain Med. 2016 Apr10. 23;6(3):e35190.11. Dalkara T, Zervas NT, Moskowitz MA. From spreading depression to the trigeminovascular system. Neurol Sci. 2006 May;27 Suppl 2:S86-90.12. Sheeler RD, Garza I, Vargas BB, O’Neil AE. Chronic Daily Headache: Ten Steps for Primary Care Providers to Regain Control. Headache. 2016 Aug 23. doi: 10.1111/head.12881. [Epub ahead of print] Sun-Edelstein C, Mauskop A. Alternative headache treatments: nutraceuticals, behavioral and physical treatments. Headache. 2011;51:469–83. November 2016. 3 Previc F The Dopaminergic Mind in Human Evolution and History 2009; Cambridge University Press. Jian Zhen Ou, Jeremy J. Cottrell, Nam Ha, Naresh Pillai, Chu K. Yao, Kyle J. Berean, Stephanie A. Ward, Danilla Grando, Jane G. Muir, Christopher J. Harrison, Udani Wijesiriwardana, Frank R. Dunshea, Peter R. Gibson, Kourosh Kalantar-zadeh. Potential of in vivo real-time gastric gas profiling: a pilot evaluation of heat-stress and modulating dietary cinnamon effect in an animal model. Scientific Reports, 2016; 6: 33387 DOI: 10.1038/srep33387. 10 Marques et al. The influence of maternal prenatal and early childhood nutrition and maternal prenatal stress on offspring immune system development and neurodevelopmental disorders. Front Neurosci. 2013; 7: 120. 2 House JS, Landis KR, Umberson D (1988) Social relations and health. Science 241: 540–5; Hafen Q, Karren KJ, Frandsen KJ, Smith NL (1996) Mind/Body Health: The Effects of Attitudes, Emotions and Relationships , Boston: Allyn & Bacon; The GUSTO Investigators (1993) An international randomized trial comparing four thrombolytic studies for acute myocardial infarction. New England Journal of Medicine 329: 673–82. Liberopoulos EN, Mikhailidis DP. Could statins be useful in the treatment of patients with migraine? Headache 2006;46:672–5 Medeiros FL, Medeiros PL, Valença MM, Dodick D. Simvastatin for migraine prevention. Headache 2007;47:855–6. 17 Hettema JM et al. COMT contributes to genetic susceptibility shared among anxiety spectrum phenotypes. Biol Psychiatry. 2008; 64(4): 302–310. 1. Costenbader KH, et al. Genes, epigenetic regulation and environmental factors: which is the most relevant in developing autoimmune diseases? Autoimmun Rev. 2012 Jun;11(8):604-9. 2. Ashan H et al. Oxygen free radicals and systemic autoimmunity. Clin Exp Immunol. 2003 Mar;131(3):398-404. 3. Kurien BT, Scofield RH. Autoimmunity and oxidatively modified autoantigens. Autoimmun Rev. 2008 Jul;7(7):567-73. 4. Perl A. Oxidative stress in the pathology and treatment of systemic lupus erythematosus. Nat Rev Rheumatol. 2013 Nov;9(11):674-86. 5. Wang G, Pierangeli SS, Papalardo E, Ansari GA, Khan MF. Markers of oxidative and nitrosative stress in systemic lupus erythematosus: correlation with disease activity. Arthritis Rheum. 2010 Jul;62(7):2064-72. 6. Ortona E, Margutti P, Matarrese P, Franconi F, Malorni W. Redox state, cell death and autoimmune diseases: a gender perspective. Autoimmun Rev. 2008 Jul;7(7):579-84. 7. Costenbader KH, Kang JH, Karlson EW. Antioxidant intake and risks of rheumatoid arthritis and systemic lupus erythematosus in women. Am J Epidemiol. 2010;172:205–216. 8. Tam LS, et al. Effects of vitamins C and E on oxidative stress markers and endothelial function in patients with systemic lupus erythematosus: A double-blind, placebo-controlled pilot study. J Rheumatol 2005;32:275–282. 9. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev. 2012 Mar 14;3:CD007176. 10. Harris C, Hansen JM. Oxidative stress, thiols, and redox profiles. Methods Mol Biol. 2012;889:325-46. 11. Perricone C, De Carolis C, Perricone R. Glutathione: a key player in autoimmunity. Autoimmun Rev. 2009 Jul;8(8):697-701. 12. Richie JP Jr, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD, Muscat JE. Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. Eur J Nutr. 2015 Mar;54(2):251-63. 13. Allen J, Bradley RD. Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers. J Altern Complement Med. 2011 Sep;17(9):827-33. 14. Lai ZW, Hanczko R, Bonilla E, et al. N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2012 Sep;64(9):2937-46. 15. Lai Z-W, Hanczko R, Bonilla E, et al. N-acetylcysteine reduces disease activity by blocking mTOR in T cells of lupus patients. Arthritis and Rheumatism. 2012;64:2937–2946. 16. Doherty E, Oaks Z, Perl A. Increased mitochondrial electron transport chain activity at complex I is regulated by N-acetylcysteine in lymphocytes of patients with systemic lupus erythematosus. Antioxid Redox Signal. 2014 Jul 1;21(1):56-65. 17. Perl A, Hanczko R, Lai ZW, Oaks Z, Kelly R, Borsuk R, Asara JM, Phillips PE. Comprehensive metabolome analyses reveal N-acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic target of rapamycin. Metabolomics. 2015;11(5):1157-1174. 18. Li M, Gao W, Ma J, Zhu Y, Li X. Early-stage lupus nephritis treated with N-acetylcysteine: A report of two cases. Exp Ther Med. 2015 Aug;10(2):689-692. Epub 2015 May 21. 19. Khalili M, Azimi A, Izadi V, et al. Does lipoic acid consumption affect the cytokine profile in multiple sclerosis patients: a double-blind, placebo-controlled, randomized clinical trial. Neuroimmunomodulation. 2014;21(6):291-6. 20. Chandran B, Goel A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res. 2012 Nov;26(11):1719-25. 21. Samsami-Kor M, Daryani NE, Asl PR, Hekmatdoost A. Anti-Inflammatory Effects of Resveratrol in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo controlled Pilot Study. Arch Med Res. 2015 May;46(4):280-5. Further reading suggested by Dr Christen Rune Stensvold, PhD (http://www.blastocystis.net): [3] T.T. Macdonald and G. Monteleone. Immunity, inflammation, and allergy in the gut. Science 307: 1920–1925, 2005. View Abstract. JOINTS and BONES Originally published as “Biological and therapeutic effects of ortho-silicic acid and some ortho-silicic acid-releasing compounds: new perspectives for therapy”, Nutr Metab (Lond). 2013; 10: 2. Published online 2013 Jan 8. doi: 10.1186/1743-7075-10-2 as an Open Access article by BioMed Cantral. 3 Witthöft M, Rubin GJ (2013), Are media warnings about the adverse health effects of modern life self-fulfilling? An experimental study on idiopathic environmental intolerance attributed to electromagnetic fields (IEI-EMF) Journal of Psychosomatic Research. 33. Miller DM, Lund BO, Woods JS (1991) Reactivity of Hg(II) with superoxide: evidence for the catalytic dismutation of superoxide by Hg(II).J BiochemToxicol 6: 293-298. 58. Hagele TJ, Mazerik JN, Gregory A, Kaufman B, Magalang U, et al. (2007) Mercury activates vascular endothelial cell phospholipase D through thiols and oxidative stress.Int J Toxicol 26: 57-69. Candyce H. Kroenke, Yvonne L. Michael, Elizabeth M. Poole, Marilyn L. Kwan, Sarah Nechuta, Eric Leas, Bette J. Caan, John Pierce, Xiao-Ou Shu, Ying Zheng, Wendy Y. Chen. Postdiagnosis social networks and breast cancer mortality in the After Breast Cancer Pooling Project . Cancer , 2016; DOI: 10.1002/cncr.30440. References. Stensvold, C., (2012). Thinking Blastocystis Out Of The Box. Trends in Parasitology DOI: 10.1016/j.pt.2012.05.004. Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour. Anthony J. Filiano et al. Nature 535, 425–429. 5 McEwan Neuroimage 2009;47(3):911-913. Gunness, J. Michiels, L. Vanhaecke, S. De Smet, O. Kravchuk, A. Van de Meene, M. J. Gidley. Reduction in circulating bile acid and restricted diffusion across the intestinal epithelium are associated with a decrease in blood cholesterol in the presence of oat -glucan . The FASEB Journal , 2016; 30 (12): 4227 DOI: 10.1096/fj.201600465R. June 2016. 10 Olde Hartman TC, Lucassen PL, van de Lisdonk EH et al (2004) Chronic functional somatic symptoms: a single syndrome? British Journal of General Practice 54: 922–7. 11 See Dr Bandler’s introduction to the 1 st edition of Magic in Practice. Diabetes Res Clin Pract. 2009 Feb;83(2):e40-2. doi: 10.1016/j.diabres.2008.11.014. Epub 2008 Dec 23. Immediate and long-term effects of glucomannan on total ghrelin and leptin in type 2 diabetes mellitus. Chearskul S1, Kriengsinyos W, Kooptiwut S, Sangurai S, Onreabroi S, Churintaraphan M, Semprasert N, Nitiyanant W. Somadina Emineke, Alan J Cooper, Sarah Fouch, Brian R Birch, Bashir A Lwaleed. Diluted honey inhibits biofilm formation: potential application in urinary catheter management? Journal of Clinical Pathology , 2016; jclinpath-2015-203546 DOI: 10.1136/jclinpath-2015-203546. NEWS Arch Intern Med. 1999 Sep 27;159(17):1981-7.). Homeopathy re-revisited: is homeopathy compatible with biomedical observations? Eskinazi D. Freddie C. Hamdy, et al. 10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer . New England Journal of Medicine , 2016; DOI: 10.1056/NEJMoa1606220. BEN BROWN Detoxification. Pietro Ghezzi, Vincent Jaquet, Fabrizio Marcucci, Harald H.H.W. Schmidt. The oxidative stress theory of disease: levels of evidence and epistemological aspects . British Journal of Pharmacology , 2016; DOI: 10.1111/bph.13544. Naama Geva-Zatorsky, Esen Sefik, Lindsay Kua, Lesley Pasman, Tze Guan Tan, Adriana Ortiz-Lopez, Tsering Bakto Yanortsang, Liang Yang, Ray Jupp, Diane Mathis, Christophe Benoist, Dennis L. Kasper. Mining the Human Gut Microbiota for Immunomodulatory Organisms . Cell , 2017; DOI: 10.1016/j.cell.2017.01.022. 9 Coversation with author. Br J Sports Med. 2008 Dec;42(12):969-73. doi: 10.1136/bjsm.2008.050369. Epub 2008 Aug 21. Antibiotic treatment in patients with low-back pain associated with Modic changes Type 1 (bone oedema): a pilot study. 5. Bloomer RJ, Kabir MM, Marshall KE, Canale RE, Farney TM. Postprandial oxidative stress in response to dextrose and lipid meals of differing size. Lipids Health Dis. 2010 Jul 27;9:79. 6 Jankord. Ann N Y Acad Sci 2008;148:64-73. April 2016. Eswaran, S.L., et al. A randomised controlled trial comparing the low FODMAP diet vs. modified NICE guidelines in US adults with IBS-D. Am J Gastroenterol. 2016 Dec; 111(12):1824-1832. Iranio, G. Digestive enzyme supplementation in gastrointestinal diseases. Curr Drug Metab. 2016 Feb; 17(2):187–193. Moayyedi, P., et al. The efficacy of probiotics in the treatment of. Matthieu Deschamps, Guillaume Laval, Maud Fagny, Yuval Itan, Laurent Abel, Jean-Laurent Casanova, Etienne Patin, Lluis Quintana-Murci. Genomic Signatures of Selective Pressures and Introgression from Archaic Hominins at Human Innate Immunity Genes. The American Journal of Human Genetics, 2016; 98 (1): 5 DOI: 10.1016/j.ajhg.2015.11.014 Michael Dannemann, Aida M. Andrés, Janet Kelso. Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Human Toll-like Receptors. The American Journal of Human Genetics, 2016; 98 (1): 22 DOI: 10.1016/j.ajhg.2015.11.015 Tabea Brick, Yvonne Schober, Christian Böcking, Juha Pekkanen, Jon Genuneit, Georg Loss, Jean-Charles Dalphin, Josef Riedler, Roger Lauener, Wolfgang Andreas Nockher, Harald Renz, Outi Vaarala, Charlotte Braun-Fahrländer, Erika von Mutius, Markus Johannes Ege, Petra Ina Pfefferle. ω-3 fatty acids contribute to the asthma-protective effect of unprocessed cow’s milk. Journal of Allergy and Clinical Immunology, 2016; DOI: 10.1016/j.jaci.2015.10.042 RESEARCH YihQ is a sulfoquinovosidase that cleaves sulfoquinovosyl diacylglyceride sulfolipids Gaetano Speciale, Yi Jin, Gideon J Davies, Spencer J Williams & Ethan D Goddard-Borger Nature Chemical Biology 2016, 12, 215–217. doi:10.1038/nchembio.2023. Witawas Handee, Xiaobo Li, Kevin W. Hall, Xiexiong Deng, Pan Li, Christoph Benning, Barry L. Williams, Min-Hao Kuo. An Energy-Independent Pro-longevity Function of Triacylglycerol in Yeast. PLOS Genetics, 2016; 12 (2): e1005878 DOI: 10.1371/journal.pgen.1005878 Loucks, Eric B.; Gilman, Stephen E.; Britton, Willoughby B.; Gutman, Roee; Eaton, Charles B.; Buka, Stephen L. Associations of Mindfulness with Glucose Regulation and Diabetes. American Journal of Health Behavior, February 2016 DOI: 10.5993/AJHB.40.2.11 Samuel E. Marsh, Edsel M. Abud, Anita Lakatos, Alborz Karimzadeh, Stephen T. Yeung, Hayk Davtyan, Gianna M. Fote, Lydia Lau, Jason G. Weinger, Thomas E. Lane, Matthew A. Inlay, Wayne W. Poon, Mathew Blurton-Jones. The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function. Proceedings of the National Academy of Sciences, 2016; 201525466 DOI: 10.1073/pnas.1525466113 Sean M. Grimmond et al. Genomic analyses identify molecular subtypes of pancreatic cancer. Nature, 2016; DOI: 10.1038/nature16965 Influence of Obesity on Breast Density Reduction by Omega-3 Fatty Acids: Evidence from a Randomized Clinical Trial. Sandhu N, Schetter SE, Liao J, Hartman TJ, Richie JP, McGinley J, Thompson HJ, Prokopczyk B, DuBrock C, Signori C, Hamilton C, Calcagnotto A, Trushin N, Aliaga C, Demers LM, El-Bayoumy K, Manni A. Cancer Prev Res (Phila). 2015 Dec 29. [Epub ahead of print] Aubrey J Cunnington, Kathleen Sim, Aniko Deierl, J Simon Kroll, Eimear Brannigan, Jonathan Darby. “Vaginal seeding” of infants born by caesarean section. BMJ, 2016; i227 DOI: 10.1136/bmj.i227 Molly K. Gibson, Bin Wang, Sara Ahmadi, Carey-Ann D. Burnham, Phillip I. Tarr, Barbara B. Warner, Gautam Dantas. Developmental dynamics of the preterm infant gut microbiota and antibiotic resistome. Nature Microbiology, 2016; 16024 DOI: 10.1038/nmicrobiol.2016.24. Mi-Sung Kim, Sarah A. Krawczyk, Ludivine Doridot, Alan J. Fowler, Jennifer X. Wang, Sunia A. Trauger, Hye-Lim Noh, Hee Joon Kang, John K. Meissen, Matthew Blatnik, Jason K. Kim, Michelle Lai, Mark A. Herman. ChREBP regulates fructose-induced glucose production independently of insulin signaling . Journal of Clinical Investigation , 2016; DOI: 10.1172/JCI81993. 24. Dunstan DW, Kingwell BA, Larsen R, Healy GN, Cerin E, Hamilton MT, Shaw JE, Bertovic DA, Zimmet PZ, Salmon J, Owen N. Breaking up prolonged sitting reduces postprandial glucose and insulin responses. Diabetes Care. 2012 May;35(5):976-83. 77. Pedersen EB, Jørgensen ME, Pedersen MB, Siggaard C, Sørensen TB, et al. (2005) Relationship between mercury in blood and 24-h ambulatory blood pressure in Greenlanders and Danes.Am J Hypertens 18: 612-618. 28. Clarkson TW (1997) The toxicology of mercury.Crit Rev Clin Lab Sci 34: 369-403. 8 Langer E, Dillon M, Kurtz R, and Katz M (1998) Believing is Seeing, Harvard University, Department of Psychology. * GSC – Genetically Sensitive Client- Chrysalis Effect Specialist Practitioner Training Elaine Wilkins: http://www.thechrysaliseffectpractitioners.com/. Fariduddin AKM, Misbahuddin M, Manun MIR, Nahar N. Alcohol extract and residue of spirulina in the prevention of accumulation of arsenic in rats. Bang J Physiol Pharmacol 2001; 17:15-7. Tachino N, Guo D, Dashwood WM, Yamane S, Larsen R, Dashwood R. Mechanisms of the in vitro antimutagenic action of chlorophyllin against benzo[a]pyrene: studies of enzyme inhibition, molecular complex formation and degradation of the ultimate carcinogen. Mutat Res. 1994;308(2):191-203. Dashwood R, Yamane S, Larsen R. Study of the forces of stabilizing complexes between chlorophylls and heterocyclic amine mutagens. Environ Mol Mutagen. 1996;27(3):211-218 Breinholt V, Schimerlik M, Dashwood R, Bailey G. Mechanisms of chlorophyllin anticarcinogenesis against aflatoxin B1: complex formation with the carcinogen. Chem Res Toxicol. 1995;8(4):506-514. Morita K, Ogata M, Hasegawa T. Chlorophyll derived from Chlorella inhibits dioxin absorption from the gastrointestinal tract and accelerates dioxin excretion in rats. Environ Health Perspect. 2001 Mar;109(3):289-94. Misbahuddin M, Islam AZ, Khandker S, et al. Efficacy of spirulina extract plus zinc in patients of chronic arsenic poisoning: a randomized placebo-controlled study. Clin Toxicol (Phila). 2006;44(2):135-41. Genuis SJ, Curtis L, Birkholz D. Gastrointestinal Elimination of Perfluorinated Compounds Using Cholestyramine and Chlorella pyrenoidosa. ISRN Toxicol. 2013 Sep 9;2013:657849. Egner PA, Muñoz A, Kensler TW. Chemoprevention with chlorophyllin in individuals exposed to dietary aflatoxin. Mutat Res. 2003 Feb-Mar;523-524:209-16. Nakano S, Noguchi T, Takekoshi H, Suzuki G, Nakano M. Maternal-fetal distribution and transfer of dioxins in pregnant women in Japan, and attempts to reduce maternal transfer with Chlorella (Chlorella pyrenoidosa) supplements. Chemosphere. 2005 Dec;61(9):1244-55. Published online 2011 Aug 6. doi: 10.1016/j.tcb.2011.06.008. 29. Insug O, Datar S, Koch CJ, Shapiro IM, Shenker BJ (1997) Mercuric compounds inhibit human monocyte function by inducing apoptosis: evidence for formation of reactive oxygen species, development of mitochondrial membrane permeability transition and loss of reductive reserve. Toxicology 124:211-224. BRAIN HEALTH Miguel’s key papers and suggestions for further reading. Christoph A. Thaiss et al. Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations . Cell , December 2016 DOI: 10.1016/j.cell.2016.11.003. 73. Smith KM, Barraj LM, Kantor M, Sahyoun NR (2009) Relationship between fish intake, n-3 fatty acids, mercury and risk markers of CHD (National Health and Nutrition Examination Survey 1999-2002).Public Health Nutr 12: 1261-1269. Bhullar, K. S. & Rupasinghe, H. P. (2013) Polyphenols: multipotent therapeutic agents in neurodegenerative diseases. Oxid Med Cell Longev, 2013pp. 891748. Shu G. Chen, Vilius Stribinskis, Madhavi J. Rane, Donald R. Demuth, Evelyne Gozal, Andrew M. Roberts, Rekha Jagadapillai, Ruolan Liu, Kyonghwan Choe, Bhooma Shivakumar, Francheska Son, Shunying Jin, Richard Kerber, Anthony Adame, Eliezer Masliah, Robert P. Friedland. Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans . Scientific Reports , 2016; 6: 34477 DOI: 10.1038/srep34477. 36. Rungby J, Ernst E (1992) Experimentally induced lipid peroxidation after exposure to chromium, mercury or silver: interactions with carbon tetrachloride.PharmacolToxicol 70: 205-207. 11 Botiglieri S-Adenosyl-L-methionine (SAMe): from the bench to the bedside—molecular basis of a pleiotrophic molecule. Am J Clin Nutr November 2002 vol. 76 no. 5 1151S-1157S. Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis. Andrew H. Moeller et al. Science 22 Jul 2016: Vol. 353, Issue 6297, pp. 380-382 doi: 10.1126/science.aaf3951. 19 Mandelli L et al. Interaction between serotonin transporter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders. Int.J.Neuropsychopharmacol. 2007; 10 (4): 437-447. LYME – JONATHAN OPRCHARD Eur Spine J. 2013 Apr;22(4):697-707. doi: 10.1007/s00586-013-2675-y. Epub 2013 Feb 13. Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized clinical controlled trial of efficacy. 48. Virtanen JK, Voutilainen S, Rissanen TH, Mursu J, Tuomainen TP, et al. (2005) Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in eastern Finland.ArteriosclerThrombVascBiol 25: 228-233. 55. Garland M, Morris JS, Rosner BA, Stampfer MJ, Spate VL, et al. (1993) Toenail trace element levels as biomarkers: reproducibility over a 6-year period.Cancer Epidemiol Biomarkers Prev 2: 493-497. Kirby E D et al. Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2. eLife 2013, 2: 1-23. http://doi.org/10.7554/eLife.00362 Cahill L et al. Enhanced human memory consolidation with post-learning stress: interaction with the degree of arousal at encoding. Learn. Mem 2003. 10, 270–274. 10.1101/lm.62403 Rogers CR, A way of being. Boston: Houghton Mifflin Company, 1995. Clifford D and Curtis L, Motivational interviewing in nutrition and fitness. The Guildford Press, 2016 Gardner B et al. Making health habitual: the psychology of “habit-formation” and general practice.The British Journal of General Practice 2012, 62: 664–666. LEARNING ZONE – LYME. Natoli JL, Manack A, Dean B, Butler Q, Turket CC, Stovner L, et al. Global prevalence of chronic migraine: a systematic review. Cephalalgia. 2010;30:599–609. Temporal analysis reveals individual and common core and relation to intestinal symptoms. PLoS One, 2011 Jul; 6(7):e23035. JAMA Oncol . Published online July 07, 2016. Aggarwal BB, Yuan W, Li S, Gupta SC. Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric. Mol Nutr Food Res. 2013 Sep;57(9):1529-42. 14. Sun-Edelstein C, Mauskop A. Foods and supplements in the management of migraine headaches. Clin J Pain. 2009 Jun;25(5):446-52. 15. Cámara-Lemarroy CR, Rodriguez-Gutierrez R, Monreal-Robles R, Marfil-Rivera A. Gastrointestinal disorders associated with migraine: A comprehensive review. World J Gastroenterol. 2016 Sep 28;22(36):8149-60. Redox modulation of cellular stress response and lipoxin A4 expression by Hericium Erinaceus in rat brain: relevance to Alzheimer’s disease pathogenesis . A. Trovato et al. Immunity & Ageing201613:23. Brown BI. Nutritional Detoxification (article in preparation). 2017. Unpublished. Kiuchi, F.; Goto, Y.; Sugimoto, N.; Akao, N.; Kondo, K.; Tsuda, Y. Nematocidal activity of turmeric: Synergistic action of curuminoids. Pharm. Bull. 1993, 41 , 1640–1643. 53. Marckmann P, Grønbaek M (1999) Fish consumption and coronary heart disease mortality. A systematic review of prospective cohort studies.Eur J ClinNutr 53: 585-590. Human Gut-Derived Prevotella histicola Suppresses Inflammatory Arthritis in Humanized Mice. Marietta EV, Murray JA, Luckey DH, Jeraldo PR, Lamba A, Patel R, Luthra HS, Mangalam A2, Taneja V. 10. O’Keefe JH, Abuannadi M, Lavie CJ, Bell DS. Strategies for optimizing glycemic control and cardiovascular prognosis in patients with type 2 diabetes mellitus. Mayo Clin Proc. 2011 Feb;86(2):128-38. Cascalheira, J. F., Goncalves, M., Barroso, M., Castro, R., Palmeira, M., Serpa, A., Dias-Cabral, A. C., Domingues, F. C. & Almeida, S. (2015) Association of the transcobalamin II gene 776C –> G polymorphism with Alzheimer’s type dementia: dependence on the 5, 10-methylenetetrahydrofolate reductase 1298A –> C polymorphism genotype. Ann Clin Biochem, 52(Pt 4) pp. 448-55. laak EE, et al. Impact of postprandial glycaemia on health and prevention of disease. Obes Rev. 2012 Oct;13(10):923-84. Saskia F. Erttmann, Anetta Hartlova, Marta Sloniecka, Faizal A.M. Raffi, Ava Hosseinzadeh, Tomas Edgren, Reza Rofougaran, Ulrike Resch, Maria Fällman, Torben Ek, and Nelson O. Gekara. Loss of the DNA Damage Repair Kinase ATM Impairs Inflammasome-Dependent Anti-Bacterial Innate Immunity . Immunity , 2016 DOI: 10.1016/j.immuni.2016.06.018. Shen L, Liu CC, An CY, Ji HF. How does curcumin work with poor bioavailability? Clues from experimental and theoretical studies. Sci Rep. 2016 Feb 18;6:20872. Jäger R, Lowery RP, Calvanese A, Joy JM, Purpura M, Wilson JM. Comparative absorption of curcumin formulations. Nutr J. 2014;13:1–8. NEWS Emily G Severance, Kristin L Gressitt, Catherine R Stallings, Emily Katsafanas, Lucy A Schweinfurth, Christina L Savage, Maria B Adamos, Kevin M Sweeney, Andrea E Origoni, Sunil Khushalani, F Markus Leweke, Faith B Dickerson, Robert H Yolken. Candida albicans exposures, sex specificity and cognitive deficits in schizophrenia and bipolar disorder. npj Schizophrenia, 2016; 2: 16018 DOI: 10.1038/npjschz.2016.18 Martin A Makary, Michael Daniel. Medical error—the third leading cause of death in the US. BMJ, 2016; i2139 DOI: 10.1136/bmj.i2139 Jacquelaine Bartlett, Irene M. Predazzi, Scott M. Williams, William S. Bush, Yeunjung Kim, Stephen Havas, Peter P. Toth, Sergio Fazio, Michael Miller. Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor? Circulation: Cardiovascular Quality and Outcomes, 2016; CIRCOUTCOMES.115.002436 DOI: 10.1161/CIRCOUTCOMES.115.002436 Nutrition. 2016 Feb 13. pii: S0899-9007(16)00075-7. doi: 10.1016/j.nut.2016.01.021. [Epub ahead of print]Is it gluten-free? Relationship between self-reported gluten-free diet adherence and knowledge of gluten content of foods. Silvester JA1, Weiten D2, Graff LA3, Walker JR3, Duerksen DR4 (Nutrition 2016, doi: 10.1016/j.nut.2016.01.021.) NEW RELEASES ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies. 31. Marmura MJ, Silberstein SD, Schwedt TJ. The acute treatment of migraine in adults: the american headache society evidence assessment of migraine pharmacotherapies. Headache. 2015 Jan;55(1):3-20. Michelle Beaumont, Julia K. Goodrich, Matthew A. Jackson, Idil Yet, Emily R. Davenport, Sara Vieira-Silva, Justine Debelius, Tess Pallister, Massimo Mangino, Jeroen Raes, Rob Knight, Andrew G. Clark, Ruth E. Ley, Tim D. Spector, Jordana T. Bell. Heritable components of the human fecal microbiome are associated with visceral fat . Genome Biology , 2016; 17 (1) DOI: 10.1186/s13059-016-1052-7. Ann Rheum Dis. 2017 Jan 9. pii: annrheumdis-2016-210000. doi: 10.1136/annrheumdis-2016-210000. [Epub ahead of print] Sarah Bettini et al. Scientific Reports 7 , Article number: 40373 (2017). doi:10.1038/srep40373. BEN BROWN 1. Dash SR, O’Neil A, Jacka FN. Diet and Common Mental Disorders: The Imperative to Translate Evidence into Action. Front Public Health. 2016 Apr 29;4:81. irritable bowel syndrome: A systematic review. Gut. 2010 Mar; 59(3):325–32. Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalised Nutrition: Part 1 – Fields of Precision Nutrition. 62. Fillion M, Mergler D, Sousa Passos CJ, Larribe F, Lemire M, et al. (2006) A preliminary study of mercury exposure and blood pressure in the Brazilian Amazon.Environ Health 5: 29. 80. Valera B, Dewailly E, Poirier P (2008) Cardiac autonomic activity and blood pressure among Nunavik Inuit adults exposed to environmental mercury: a cross-sectional study.Environ Health 7: 29. 74. Skoczyska A, Jedrejko M, Martynowicz H, Poreba R, Affelska-Jercha A, et al. (2010) [The cardiovascular risk in chemical factory workers exposed to mercury vapor].Med Pr 61: 381-391. [5] O. Vaarala, M.A. Atkinson, and J. Neu. The “perfect storm” for type 1 diabetes: The complex interplay between intestinal microbiota, gut permeability, and mucosal immunity. Diabetes 57: 2555–2562, 2008. View Abstract. Joseph P Zackular, Jessica L Moore, Ashley T Jordan, Lillian J Juttukonda, Michael J Noto, Maribeth R Nicholson, Jonathan D Crews, Matthew W Semler, Yaofang Zhang, Lorraine B Ware, M Kay Washington, Walter J Chazin, Richard M Caprioli, Eric P Skaar. Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection . Nature Medicine , 2016; DOI: 10.1038/nm.4174. Tollesson A, Frithz A, Berg A, Karlman G (1993) Essential fatty acids in infantile seborrheic dermatitis. Journal of the American Academy of Dermatology, 28: 957-961. Preuss CV, Wood TC, Szumlanski CL, Raftogianis RB, Otterness DM, Girard B, Scott MC, Weinshilboum RM (1998) Human histamine n-methyltransferase pharmacogenetics: common genetic polymorphisms that alter Molecular Pharmacology, 53: 708-17. Barbosa PR, Stabler SP, Machado ALK, Braga RC, Hirata RDC, Hirata MH, Sampaio-Neto LF, Allen RH, Guerra-Shinohara EM (2007) Association between decreased vitamin levels and MTHFR, MTR and MTRR gene polymorphisms as determinants for elevated total homocysteine concentrations in pregnant European Journal of Clinical Nutrition, 62: 1010–1021. Lewis CA (2015) Enteroimmunology: a guide to the prevention and treatment of chronic inflammatory Carrabelle, Florida: Psy Press. McGuire M, Beerman KA (2015) 3rd Nutritional sciences:from fundamentals to food. Matthew Weiser, Jeremy M Simon, Bharati Kochar, Adelaide Tovar, Jennifer W Israel, Adam Robinson, Gregory R Gipson, Matthew S Schaner, Hans H Herfarth, R Balfour Sartor, Dermot P B McGovern, Reza Rahbar, Timothy S Sadiq, Mark J Koruda, Terrence S Furey, Shehzad Z Sheikh. Molecular classification of Crohn’s disease reveals two clinically relevant subtypes . Gut , October 2016 DOI: 10.1136/gutjnl-2016-312518. ALLERGIES and INTOLERANCES Perkin MR, Logan K, et al. Randomized trial of the early introduction of allergenic foods in breastfed infants. New England Journal of Medicine, 2016 DOI 10.1056/NEJMoa1514210 [Epub ahead of print] Jung-Hwan Kim, Eun-Ji Jeun, Chun-Pyo Hong, Seong-Hoon Kim, Min Seong Jang, Eun-Jung Lee, Sook Jin Moon, Chang Ho Yun, Sin-Hyeog Im, Seok-Geun Jeong, Beom-Young Park, Kyong-Tai Kim, Ju-Young Seoh, Yoon-Keun Kim, Sung-Jong Oh, Jun-Sang Ham, Bo-Gie Yang, Myoung Ho Jang. Extracellular vesicle–derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression. Journal of Allergy and Clinical Immunology, 2016; 137 (2): 507 DOI: 10.1016/j.jaci.2015.08.016 Roberto Berni Canani, Naseer Sangwan, Andrew T Stefka, Rita Nocerino, Lorella Paparo, Rosita Aitoro, Antonio Calignano, Aly A Khan, Jack A Gilbert, Cathryn R Nagler. Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants. The ISME Journal, 2015; DOI: 10.1038/ismej.2015.151. Belmont, California: Wadsworth, Cengage Learning. Published online 2015 Nov 12. doi: 10.1556/1886.2015.00031. Pedret, A., Valls, R. M., Fernandez-Castillejo, S., Catalan, U., Romeu, M., Giralt, M., Lamuela-Raventos, R. M., Medina-Remon, A., Arija, V., Aranda, N., Espinel, A., Delgado, M. A. & Sola, R. (2012) Polyphenol-rich foods exhibit DNA antioxidative properties and protect the glutathione system in healthy subjects. Mol Nutr Food Res, 56(7) pp. 1025-33. LIGHT SENSITIVITY CASE HISTORY – JENNIFER WILLIAMS. Office for National Statistics. Suicides in the United Kingdom: 2014 registrations. 2016. Bertolote JM, Fleischmann A. Suicide and psychiatric diagnosis: a worldwide perspective. World Psychiatry. 2002 Oct;1(3):181-5. Lund-Sørensen H, Benros ME, Madsen T, et al. A nationwide cohort study of the association between hospitalization with infection and risk of death by suicide [published online August 10, 2016]. JAMA Psychiatry. doi:10.1001 /jamapsychiatry.2016.1594. Brundin L, Erhardt S, Bryleva EY, Achtyes ED, Postolache TT. The role of inflammation in suicidal behaviour. Acta Psychiatr Scand. 2015 Sep;132(3):192-203. Gibbs HM, Davis L, Han X, Clothier J, Eads LA, Cáceda R. Association between C-reactive protein and suicidal behavior in an adult inpatient population. J Psychiatr Res. 2016 Aug;79:28-33. Miller AH, Maletic V, Raison CL. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry. 2009 May 1;65(9):732-41. Berk M, Williams LJ, Jacka FN, O’Neil A, Pasco JA, Moylan S, Allen NB, Stuart AL, Hayley AC, Byrne ML, Maes M. So depression is an inflammatory disease, but where does the inflammation come from? BMC Med. 2013 Sep 12;11:200. Tanskanen A, Hibbeln JR, Hintikka J, Haatainen K, Honkalampi K, Viinamäki H. Fish consumption, depression, and suicidality in a general population. Arch Gen Psychiatry. 2001 May;58(5):512-3. Huan M, Hamazaki K, Sun Y, Itomura M, Liu H, Kang W, Watanabe S, Terasawa K, Hamazaki T. Suicide attempt and n-3 fatty acid levels in red blood cells: a case control study in China. Biol Psychiatry. 2004 Oct 1;56(7):490-6. Shivappa N, Schoenaker DA, Hebert JR, Mishra GD. Association between inflammatory potential of diet and risk of depression in middle-aged women: the Australian Longitudinal Study on Women’s Health. Br J Nutr. 2016 Aug 8:1-10. [Epub ahead of print] Hawton K, van Heeringen K. Suicide. Lancet 2009; 373: 1372–81. Stahl ST, Albert SM, Dew MA, Lockovich MH, Reynolds CF 3rd. Coaching in healthy dietary practices in at-risk older adults: a case of indicated depression prevention. Am J Psychiatry. 2014 May;171(5):499-505. Nanri A, Mizoue T, Poudel-Tandukar K, Noda M, Kato M, Kurotani K, Goto A, Oba S, Inoue M, Tsugane S; Japan Public Health Center-based Prospective Study Group. Dietary patterns and suicide in Japanese adults: the Japan Public Health Center-based Prospective Study. Br J Psychiatry. 2013 Dec;203(6):422-7. Opie RS, Itsiopoulos C, Parletta N, Sanchez-Villegas A, Akbaraly TN, Ruusunen A, Jacka FN.Dietary recommendations for the prevention of depression.Nutr Neurosci. 2015 Aug 28. [Epub ahead of print] Van der Borght K, Köhnke R, Göransson N, Deierborg T, Brundin P, Erlanson-Albertsson C, Lindqvist A. Reduced neurogenesis in the rat hippocampus following high fructose consumption. Regul Pept. 2011 Feb 25;167(1):26-30. Pan X, Zhang C, Shi Z. Soft drink and sweet food consumption and suicidal behaviours among Chinese adolescents. Acta Paediatr. 2011 Nov;100(11):e215-22. Solnick SJ, Hemenway D. Soft drinks, aggression and suicidal behaviour in US high school students. Int J Inj Contr Saf Promot. 2014;21(3):266-73. Shi Z, Taylor AW, Wittert G, Goldney R, Gill TK. Soft drink consumption and mental health problems among adults in Australia. Public Health Nutr. 2010 Jul;13(7):1073-9. Al-Karawi D, Al Mamoori DA, Tayyar Y. The Role of Curcumin Administration in Patients with Major Depressive Disorder: Mini Meta-Analysis of Clinical Trials. Phytother Res. 2016 Feb;30(2):175-83. McNamara RK. Long-chain omega-3 fatty acid deficiency in mood disorders: rationale for treatment and prevention. Curr Drug Discov Technol. 2013 Sep;10(3):233-44. Sublette ME, Hibbeln JR, Galfalvy H, Oquendo MA, Mann JJ. Omega-3 polyunsaturated essential fatty acid status as a predictor of future suicide risk. Am J Psychiatry. 2006 Jun;163(6):1100-2. Marriott BP, Hibbeln JR, Killeen TK, Magruder KM, Holes-Lewis K, Tolliver BK, Turner TH; BRAVO Group. Design and methods for the Better Resiliency Among Veterans and non-Veterans with Omega-3s (BRAVO) study: A double blind, placebo-controlled trial of omega-3 fatty acid supplementation among adult individuals at risk of suicide. Contemp Clin Trials. 2016 Mar;47:325-33. Shaffer JA, Edmondson D, Wasson LT, Falzon L, Homma K, Ezeokoli N, Li P,Davidson KW. Vitamin D supplementation for depressive symptoms: a systematic review and meta-analysis of randomized controlled trials. Psychosom Med. 2014 Apr;76(3):190-6. Grudet C, Malm J, Westrin A, Brundin L. Suicidal patients are deficient in vitamin D, associated with a pro-inflammatory status in the blood. Psychoneuroendocrinology. 2014 Dec;50:210-9. 50. Connor WE (2000) Importance of n-3 fatty acids in health and disease.Am J ClinNutr 71: 171S-5S. 15 Cohen IL et al. Autism severity is associated with child and maternal MAOA genotypes. Clinical Genet. 2011; 79 (4): 355-362. Scoditti, E., Capurso, C., Capurso, A. & Massaro, M. (2014) Vascular effects of the Mediterranean diet-part II: role of omega-3 fatty acids and olive oil polyphenols. Vascul Pharmacol, 63(3) pp. 127-34. Shen, L. & Ji, H. F. (2015) Associations between Homocysteine, Folic Acid, Vitamin B12 and Alzheimer’s Disease: Insights from Meta-Analyses. J Alzheimers Dis, 46(3) pp. 777-90. Lopes Da Silva, S., Vellas, B., Elemans, S., Luchsinger, J., Kamphuis, P., Yaffe, K., Sijben, J., Groenendijk, M. & Stijnen, T. (2014) Plasma nutrient status of patients with Alzheimer’s disease: Systematic review and meta-analysis. Alzheimers Dement, 10(4) pp. 485-502. GUT HEALTH and PROBIOTICS Julie Urban, Daniel J. Fergus, Amy M. Savage, Megan Ehlers, Holly L. Menninger, Robert R. Dunn, Julie E. Horvath. The effect of habitual and experimental antiperspirant and deodorant product use on the armpit microbiome. PeerJ, 2016; 4: e1605 DOI: 10.7717/peerj.1605 Shuichi Tonomura, Masafumi Ihara, Tomohiro Kawano, Tomotaka Tanaka, Yoshinori Okuno, Satoshi Saito, Robert P. Friedland, Nagato Kuriyama, Ryota Nomura, Yoshiyuki Watanabe, Kazuhiko Nakano, Kazunori Toyoda, Kazuyuki Nagatsuka. Intracerebral hemorrhage and deep microbleeds associated with cnm-positive Streptococcus mutans; a hospital cohort study. Scientific Reports, 2016; 6: 20074 DOI: 10.1038/srep20074 Hongjie Li, Yanyan Qi, Heinrich Jasper. Preventing Age-Related Decline of Gut Compartmentalization Limits Microbiota Dysbiosis and Extends Lifespan. Cell Host & Microbe, 2016; 19 (2): 240 DOI: 10.1016/j.chom.2016.01.008 Vinegar Treatment Prevents the Development of Murine Experimental Colitis via Inhibition of Inflammation and Apoptosis Fengge Shen†, Jiaxuan Feng§, Xinhui Wang†, Zhimin Qi†, Xiaochen Shi†, Yanan An†, Qiaoli Zhang†, Chao Wang†, Mingyuan Liu†#, Bo Liu*†, and Lu Yu*† J. Agric. Food Chem., 2016, 64 (5), pp 1111–1121, DOI: 10.1021/acs.jafc.5b05415. 21. Sensenig J, Johnson M, Staverosky T. Treatment of migraine with targeted nutrition focused on improved assimilation and elimination. Altern Med Rev. 2001 Oct;6(5):488-94. 22 Cengiz FB et al. Genetic polymorphism of the serotonin transporter gene, SLC6A4 rs16965628, is associated with obsessive compulsive disorder. Genet Test Mol Biomarkers. 2015; 19 (5): 228-234. Daniel Brugger, Wilhelm M. Windisch. Subclinical zinc deficiency impairs pancreatic digestive enzyme activity and digestive capacity of weaned piglets. British Journal of Nutrition, 2016; 1 (doi: 10.1017/S0007114516002105). 1. Keating MH, Mahaffey KR, Schoemy R, Rice GE, Bullock R, et al. (1997) Mercury study report to Congress. Vol. I. Executive summary. EPA-452/R-97-003, Environmental Protection Agency, Washington, DC. 2. (2000) Committee on the Toxicological Effects of Methylmercury, Board on Environmental Studies and Toxicology, Commission on Life Sciences. Toxicological effects of methylmercury. National Research Council, Washington, DC. 3. Magos L (1997) Physiology and toxicology of mercury. Met Ions BiolSyst 34: 321-370. 4. Clarkson TW, Magos L, Myers GJ (2003) The toxicology of mercury-current exposures and clinical manifestations. N Engl J Med 349: 1731-1737. 5. Guallar E, Sanz-Gallardo MI, van’t Veer P, Bode P, Aro A, et al. (2002) Mercury, fish oils, and the risk of myocardial infarction.N Engl J Med 347: 1747-1754. 6. Weinhold B (2004) Environmental cardiology: getting to the heart of the matter.Environ Health Perspect 112: A880-887. 7. Bhatnagar A (2006) Environmental cardiology: studying mechanistic links between pollution and heart disease.Circ Res 99: 692-705. 8. (2012)CERCLA Priority List of Hazardous Substances. 9. Ahlqwist M, Bengtsson C, Lapidus L, Gergdahl IA, Schütz A (1999) Serum mercury concentration in relation to survival, symptoms, and diseases: results from the prospective population study of women in Gothenburg, Sweden.ActaOdontolScand 57: 168-174. 10. Bergdahl IA, Schütz A, Ahlqwist M, Bengtsson C, Lapidus L, et al. (1998) Methylmercury and inorganic mercury in serum–correlation to fish consumption and dental amalgam in a cohort of women born in 1922.Environ Res 77: 20-24. 11. Salonen JT, Seppänen K, Nyyssönen K, Korpela H, Kauhanen J, et al. (1995) Intake of mercury from fish, lipid peroxidation, and the risk of myocardial infarction and coronary, cardiovascular, and any death in eastern Finnish men.Circulation 91: 645-655. 12. Yoshizawa K, Rimm EB, Morris JS, Spate VL, Hsieh CC, et al. (2002) Mercury and the risk of coronary heart disease in men.N Engl J Med 347: 1755-1760. 13. Chmielnicka J, Bem EM, Kaszubski P (1983) Organ and subcellular distribution of cadmium in rats exposed to cadmium, mercury, and selenium. Environ Res 31: 266-272. 14. Komsta-Szumska E, Chmielnicka J (1983) Effect of zinc, cadmium or copper on mercury distribution in rat tissues.ToxicolLett 17: 349-354. 15. International Programme on Chemical Safety (IPCS) (1990)Methylmercury. Environmental Health Criteria 101. Geneva: World Health Organization, USA. 16. Salonen JT, Seppänen K, Lakka TA, Salonen R, Kaplan GA (2000) Mercury accumulation and accelerated progression of carotid atherosclerosis: a population-based prospective 4-year follow-up study in men in eastern Finland.Atherosclerosis 148: 265-273. 17. Skoczyska A, Poreba R, Steinmentz-Beck A, Martynowicz H, Affelska-Jercha A, et al. (2009) The dependence between urinary mercury concentration and carotid arterial intima-media thickness in workers occupationally exposed to mercury vapour. Int J Occup Med Environ Health 22: 135-142. 18. Parízek J, Ostádalová I (1967) The protective effect of small amounts of selenite in sublimate intoxication.Experientia 23: 142-143. 19. Ganther HE, Goudie C, Sunde ML, Kopecky MJ, Wagner P (1972) Selenium: relation to decreased toxicity of methylmercury added to diets containing tuna.Science 175: 1122-1124. 20. Ganther HE, Sunde ML (1974) Effect of tuna fish and selenium on the toxicity of methylmercury: a progress report. J Food Sci 39:1-5. 21. Stoewsand GS, Bache CA, Lisk DJ (1974) Dietary selenium protection of methylmercury intoxication of Japanese quail.Bull Environ ContamToxicol 11: 152-156. 22. Sumino K, Yamamoto R, Kitamura S (1977) A role of selenium against methylmercury toxicity.Nature 268: 73-74. IHCAN Feb 2017 references. 4. Dahlhoff C, Desmarchelier C, Sailer M, Fürst RW, Haag A, et al. (2013) Hepatic Methionine Homeostasis Is Conserved in C57BL/6N Mice on High-Fat Diet Despite Major Changes in Hepatic One-Carbon Metabolism. PLoS ONE 8(3): e57387. doi: 10.1371/journal.pone.0057387. 8 Babri et al. Strain-dependent effects of prenatal maternal immune activation on anxiety- and depression-like behaviors in offspring. Brain Behav Immun. 2014 Mar;37:164-76. Sci Rep. 2016 Jun 3;6:27010. doi: 10.1038/srep27010. Paternal under-nutrition programs metabolic syndrome in offspring which can be reversed by antioxidant/vitamin food fortification in fathers. McPherson NO1,2, Fullston T1, Kang WX1, Sandeman LY1, Corbett MA3, Owens JA1, Lane M1,4. Neuro Endocrinol Lett. 2008 Dec;29(6):902-10 View Abstract. 35. Cuvin-Aralar ML, Furness RW (1991) Mercury and selenium interaction: a review.Ecotoxicol Environ Saf 21: 348-364. Gonzalez A, Hyde E, Sangwan N, Gilbert JA, Viirre E, Knight R. 2016.Migraines are correlated with higher levels of nitrate-, nitrite-, and nitric oxide-reducing oral microbes in the American Gut Project Cohort. mSystems 1(5):e00105-16. J Nutrigenet Nutrigenomics 2016;9:12-27, (DOI:10.1159/000445350) Sofi, F., et al. Effect of Triticum turgidum subsp. turanicum wheat on irritable bowel syndrome: a double-blinded randomised dietary intervention trial. Br J Nutr. 2014 Jun; 111(1):1992–9. Maagaard L., et al. Follow- up of patients with functional bowel. Tuttolomondo, A., Casuccio, A., Butta, C., Pecoraro, R., Di Raimondo, D., Della Corte, V., Arnao, V., Clemente, G., Maida, C., Simonetta, I., Miceli, G., Lucifora, B., Cirrincione, A., Di Bona, D., Corpora, F., Maugeri, R., Iacopino, D. G. & Pinto, A. (2015) Mediterranean Diet in patients with acute ischemic stroke: Relationships between Mediterranean Diet score, diagnostic subtype, and stroke severity index. Atherosclerosis, 243(1) pp. 260-7. Mizuguchi D, Das H, Matsushita AK, Maeyama C, Umehara K, Ohtoshi T, Kojima J, Nishida K, Takahashi K,Fukui, H (2008). Suppression of histamine signaling by probiotic Lac-B: a possible mechanism of its anti-allergic Journal of Pharmacological Sciences , 107: 159-166. 32. Park ST, Lim KT, Chung YT, Kim SU (1996) Methylmercury-induced neurotoxicity in cerebral neuron culture is blocked by antioxidants and NMDA receptor antagonists.Neurotoxicology 17: 37-45. Haiqiu Huang, Xiaojing Jiang, Zhenlei Xiao, Lu Yu, Quynhchi Pham, Jianghao Sun, Pei Chen, Wallace Yokoyama, Liangli Lucy Yu, Yaguang Sunny Luo, Thomas T. Y. Wang. Red Cabbage Microgreens Lower Circulating Low-Density Lipoprotein (LDL), Liver Cholesterol, and Inflammatory Cytokines in Mice Fed a High-Fat Diet . Journal of Agricultural and Food Chemistry , 2016; 64 (48): 9161 DOI: 10.1021/acs.jafc.6b03805. 38. Wierzbicki R, Prazanowski M, Michalska M, Krajewska U, Mielicki WP (2002) Disorders in blood coagulation in humans occupationally exposed to mercuric vapors. J Trace Elem Exp Med 15:21-29. Ahmed Tawakol, Amorina Ishai, Richard AP Takx, Amparo L Figueroa, Abdelrahman Ali, Yannick Kaiser, Quynh A Truong, Chloe JE Solomon, Claudia Calcagno, Venkatesh Mani, Cheuk Y Tang, Willem JM Mulder, James W Murrough, Udo Hoffmann, Matthias Nahrendorf, Lisa M Shin, Zahi A Fayad, Roger K Pitman. Relation between resting amygdalar activity and cardiovascular events: a longitudinal and cohort study . The Lancet , 2017; DOI: 10.1016/S0140-6736(16)31714-7. Katharine A. Rimes, Joanna Ashcroft, Lauren Bryan, Trudie Chalder. Emotional Suppression in Chronic Fatigue Syndrome: Experimental Study.. Health Psychology, 2016; DOI: 10.1037/hea0000341 Toni Ali-Sisto, Tommi Tolmunen, Elena Toffol, Heimo Viinamäki, Pekka Mäntyselkä, Minna Valkonen-Korhonen, Kirsi Honkalampi, Anu Ruusunen, Vidya Velagapudi, Soili M. Lehto. Purine metabolism is dysregulated in patients with major depressive disorder. Psychoneuroendocrinology, 2016; 70: 25 DOI: 10.1016/j.psyneuen.2016.04.017 Hilary P. Browne, Samuel C. Forster, Blessing O. Anonye, Nitin Kumar, B. Anne Neville, Mark D. Stares, David Goulding, Trevor D. Lawley. Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation. Nature, 2016; DOI: 10.1038/nature17645. Cell , Ocampo et al.: “In vivo amelioration of age-associated hallmarks by partial reprogramming.” DOI: 10.1016/j.cell.2016.11.052 , www.cell.com/cell/fulltext/S0092-8674(16)31664-6. 29. Breton J, Daniel C, Dewulf J, Pothion S, Froux N, Sauty M, Thomas P, Pot B, Foligné B. Gut microbiota limits heavy metals burden caused by chronic oral exposure. Toxicol Lett. 2013 Oct 24;222(2):132-8.30. Trinder M, McDowell TW, Daisley BA, Ali SN, Leong HS, Sumarah MW, Reid G. Probiotic Lactobacillus rhamnosus Reduces Organophosphate Pesticide Absorption and Toxicity to Drosophila melanogaster. Appl Environ Microbiol. 2016 Sep 30;82(20):6204-6213. 31. Bisanz JE, Enos MK, Mwanga JR, Changalucha J, Burton JP, Gloor GB, Reid G. Randomized open-label pilot study of the influence of probiotics and the gut microbiome on toxic metal levels in Tanzanian pregnant women and school children. MBio. 2014 Oct 7;5(5):e01580-14. doi: 10.1128/mBio.01580-14. Holford & Associates Ltd. 100% Digestive Health Survey, awaiting publication in February. Zar, S., et al. Food-specific serum IgG4 and IgE titers to common food antigens in irritable bowel syndrome. Am J Gastroenterol.. 2005 Jul; 100(7):1550–7; see also Zuo X.L., et al. Alterations of food antigen-specific serum immunoglobulins G and E antibodies in patients with irritable bowel syndrome and functional dyspepsia. Clin Exp Allergy. 2007 Jun; 37(6):823-30. Finn R., et al. Immunological hypersensitivity to environmental antigens in the irritable bowel syndrome. Br J Clin Pract. 1987 Dec; 41(12):1041-3. Zar, S., et al. Food-specific serum IgG4 and IgE titers to common food antigens in irritable bowel syndrome. Am J Gastroenterol.. 2005 Jul; 100(7):1550–7. Atkinson, W., et al. Food elimination based on IgG antibodies in irritable bowel syndrome: A randomised controlled trial. Gut. 2004 Oct; 53(10):1459–64 van Gils, T., et al. Prevalence and characterization of self-reported gluten. CHRIS MELETIS – ENERGY References: March 2016. broccoli sprout beverage: Results of a randomized clinical trial in China. Cancer Prev. Inmaculada Moreno, Francisco M. Codoñer, Felipe Vilella, Diana Valbuena, Juan F. Martinez-Blanch, Jorge Jimenez-Almazán, Roberto Alonso, Pilar Alamá, Jose Remohí, Antonio Pellicer, Daniel Ramon, Carlos Simon. Evidence that the endometrial microbiota has an effect on implantation success or failure . American Journal of Obstetrics and Gynecology , 2016; 215 (6): 684 DOI: 10.1016/j.ajog.2016.09.075. 24. Sato M, Kondoh M. Recent studies on metallothionein: protection against toxicity of heavy metals and oxygen free radicals. Tohoku J Exp Med. 2002 Jan;196(1):9-22.25. Hu R, Hebbar V, Kim BR, Chen C, Winnik B, Buckley B, Soteropoulos P, Tolias P, Hart RP, Kong AN. In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat. J Pharmacol Exp Ther. 2004 Jul;310(1):263-71.26. Swindell WR. Metallothionein and the biology of aging. Ageing Res Rev. 2011 Jan;10(1):132-45.27. Lamb JJ, Konda VR, Quig DW, et al. A program consisting of a phytonutrient-rich medical food and an elimination diet ameliorated fibromyalgia symptoms and promoted toxic-element detoxification in a pilot trial. Altern Ther Health Med. 2011 Mar-Apr;17(2):36-44. Henrik M. Roager, Lea B. S. Hansen, Martin I. Bahl, Henrik L. Frandsen, Vera Carvalho, Rikke J. Gøbel, Marlene D. Dalgaard, Damian R. Plichta, Morten H. Sparholt, Henrik Vestergaard, Torben Hansen, Thomas Sicheritz-Pontén, H. Bjørn Nielsen, Oluf Pedersen, Lotte Lauritzen, Mette Kristensen, Ramneek Gupta, Tine R. Licht. Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut . Nature Microbiology , 2016; 1: 16093 DOI: 10.1038/nmicrobiol.2016.93. 31. Kobal AB, Horvat M, Prezelj M, Briski AS, Krsnik M, et al. (2004) The impact of long-term past exposure to elemental mercury on antioxidative capacity and lipid peroxidation in mercury miners.J Trace Elem Med Biol 17: 261-274. ***IHCAN May 2016 REFERENCES*** January 2017. Giannis Koukkidis, Richard Haigh, Natalie Allcock, Suzanne Jordan, and Primrose Freestone. Salad leaf juices enhance Salmonella growth, fresh produce colonisation and virulence . Applied and Environmental Microbiology , November 2016 DOI: 10.1128/AEM.02416-16 Cheng-Shiuan Lee, Molly E. Lutcavage, Emily Chandler, Daniel J. Madigan, Robert M. Cerrato, Nicholas S. Fisher. Declining Mercury Concentrations in Bluefin Tuna Reflect Reduced Emissions to the North Atlantic Ocean . Environmental Science & Technology , 2016; DOI: 10.1021/acs.est.6b04328. Sung Ryeol Park, Ashootosh Tripathi, Jianfeng Wu, Pamela J. Schultz, Isaiah Yim, Thomas J. McQuade, Fengan Yu, Carl-Johan Arevang, Abraham Y. Mensah, Giselle Tamayo-Castillo, Chuanwu Xi, David H. Sherman. Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway. Nature Communications, 2016; 7: 10710 DOI: 10.1038/ncomms10710. Charbonneau et al. Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition. Cell, 2016 DOI: 10.1016/j.cell.2016.01.024. L. Claxton, M. Taylor, E. Kay. Oral health promotion: the economic benefits to the NHS of increased use of sugarfree gum in the UK. BDJ, 2016; 220 (3): 121 DOI: 10.1038/sj.bdj.2016.94. 52. (1999) GISSI-Prevenzione Investigators (GruppoItaliano per lo Studio dellaSopravvivenzanell’Infartomiocardico). Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 354:447-455. “Distinct effects of 9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing”. P Fusar-Poli, Neuroimaging Section, Division of Psychological Medicine, Institute of Psychiatry, London. Archives of General Psychiatry, January 2009. 5 Sigmund Freud The Standard Edition of the Complete Psychological Works of Sigmund Freud , translated and edited by James Strachey. The Institute of Psycho-Analysis and The Hogarth Press. ALZHEIMER’S 1,2. Prince MA, Emiliano; Guerchet, Maëlenn; Prina, Matthew. 2014; World Alzheimer Report 2014 United Kingdom: Alzheimer’s Disease International. Bolander-Gouaille C (2002) 2nd Focus on homocysteine and the vitamins involved in its metabolism: involved in its metabolism. France:Springer. Zeisel SH (2006) Choline: Critical role during fetal development and dietary requirements in adults. Annual Review of Nutrition, 26: 229-250. Mitchell ES, Conus N, Kaput J (2014) B vitamin polymorphisms and behavior: Evidence of associations with neurodevelopment, depression, schizophrenia, bipolar disorder and cognitive decline. Neuroscience & Biobehavioral Reviews, 47: 307–320. Snpedia (2016) Yasko Accessed:http://www.snpedia.com/index.php/Yasko_Methylation#MAOA_Gene 7th April 2016. University of Bristol, centre for academic primary care. MYMOP general information. [Online]Available at: http://www.bristol.ac.uk/primaryhealthcare/resources/mymop/general- information/ Bone Metabolism in Celiac Disease Chiara Zanchi, MD Grazia Di Leo, MD Luca Ronfani, MD, Stefano Martelossi, MD, Tarcisio Not, MD, Alessandro Ventura, MD Journal of Pediatrics, August 2008, Volume 153, Issue 2, Pages 262–265, DOI: http://dx.doi.org/10.1016/j.jpeds.2008.03.003. Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entity. Carroccio A1, Mansueto P, Iacono G, Soresi M, D’Alcamo A, Cavataio F, Brusca I, Florena AM, Ambrosiano G, Seidita A, Pirrone G, Rini GB. Am J Gastroenterol. 2012 Dec;107(12):1898-906; quiz 1907. doi: 10.1038/ajg.2012.236. Epub 2012 Jul 24. David K. Cole, Anna M. Bulek, Garry Dolton, Andrea J. Schauenberg, Barbara Szomolay, William Rittase, Andrew Trimby, Prithiviraj Jothikumar, Anna Fuller, Ania Skowera, Jamie Rossjohn, Cheng Zhu, John J. Miles, Mark Peakman, Linda Wooldridge, Pierre J. Rizkallah, Andrew K. Sewell. Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. Journal of Clinical Investigation, 2016; DOI: 10.1172/JCI85679. Robert I. Richards, Sarah A. Robertson, Louise V. O’Keefe, Dani Fornarino, Andrew Scott, Michael Lardelli, Bernhard T. Baune. The Enemy within: Innate Surveillance-Mediated Cell Death, the Common Mechanism of Neurodegenerative Disease. Frontiers in Neuroscience, 2016; 10 DOI: 10.3389/fnins.2016.00193 G. Hagen, T. Wisløff, I. S. Kristiansen. The predicted lifetime costs and health consequences of calcium and vitamin D supplementation for fracture prevention—the impact of cardiovascular effects. Osteoporosis International, 2016; 27 (6): 2089 DOI: 10.1007/s00198-016-3495-9 Mingzhan Xue, Martin O Weickert, Sheharyar Qureshi, Ngianga-Bakwin Kandala, Attia Anwar, Molly Waldron, Alaa Shafie, David Messenger, Mark Fowler, Gail Jenkins, Naila Rabbani, Paul J. Thornalley. Improved glycemic control and vascular function in overweight and obese subjects by glyoxalase 1 inducer formulation. Diabetes, 2016; db160153 DOI: 10.2337/db16-0153 Julia K. Goodrich, Emily R. Davenport, Michelle Beaumont, Matthew A. Jackson, Rob Knight, Carole Ober, Tim D. Spector, Jordana T. Bell, Andrew G. Clark, Ruth E. Ley. Genetic Determinants of the Gut Microbiome in UK Twins. Cell Host & Microbe, 2016; 19 (5): 731 DOI: 10.1016/j.chom.2016.04.017. 56. Mazerik JN, Mikkilineni H, Kuppusamy VA, Steinhour E, Peltz A, et al. (2007) Mercury activates phospholipase a(2) and induces formation of arachidonic Acid metabolites in vascular endothelial cells.ToxicolMech Methods 17: 541-557. Carlos Celis-Morales, et al Effect of personalized nutrition on health-related behaviour change: evidence from the Food4me European randomized controlled trial . International Journal of Epidemiology , 2016; dyw186 DOI: 10.1093/ije/dyw186. Milda Stuknytė, Margherita Maggioni, Stefano Cattaneo, Paola De Luca, Amelia Fiorilli, Anita Ferraretto, Ivano De Noni. Release of wheat gluten exorphins A5 and C5 during in vitro gastrointestinal digestion of bread and pasta and their absorption through an in vitro model of intestinal epithelium . Food Research International , 2015; 72: 208 DOI: 10.1016/j.foodres.2015.04.002. * Childhood Disrupted: How Your Biography Becomes Your Biology and How You Can Heal, by Donna Jackson Nakazawa: http://donnajacksonnakazawa.com/childhood-disrupted/. Iriti, M. & Varoni, E. M. (2015) Melatonin in Mediterranean diet, a new perspective. J Sci Food Agric, 95(12) pp. 2355-9. Marietta EV, Gomez AM, Yeoman C, Tilahun AY, Clark CR, Luckey DH, Murray JA, White BA, Kudva YC, Rajagopalan G . Low inc > Volume 1, Issue 1, 1 July 2014, Pages 49–61. Cupping therapy for acute and chronic pain management: a systematic review of randomized clinical trials. Suzanna M. Zick, ND, MPH 1,2 ; Ananda Sen, PhD 1,3 ; Gwen K. Wyatt, PhD, RN 4 ; Susan L. Murphy, PhD 5,6 ; J. Todd Arnedt, PhD 7,8,9 ; Richard E. Harris, PhD 10. Elizabeth M. Curtis, Robert van der Velde, Rebecca J. Moon, Joop P.W. van den Bergh, Piet Geusens, Frank de Vries, Tjeerd P. van Staa, Cyrus Cooper, Nicholas C. Harvey. Epidemiology of fractures in the United Kingdom 1988–2012: Variation with age, sex, geography, ethnicity and socioeconomic status. Bone, 2016; 87: 19 DOI: 10.1016/j.bone.2016.03.006. 10: 295–297. RESEARCH L.N. Yelland, B.J. Gajewski, J. Colombo, R.A. Gibson, M. Makrides, S.E. Carlson. Predicting the effect of maternal docosahexaenoic acid (DHA) supplementation to reduce early preterm birth in Australia and the United States using results of within country randomized controlled trials . Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) , 2016; 112: 44 DOI: 10.1016/j.plefa.2016.08.007. The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders. Gao B1, Doan A1, Hybertson BM1. Free online at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917919. IHCAN June 2016 references. [4] C. Catassi and A. Fasano. Celiac disease. Curr Opin Gastroenterol 24: 687–691, 2008. View Abstract. 45. Barregård L, Sällsten G, Järvholm B (1990) Mortality and cancer incidence in chloralkali workers exposed to inorganic mercury.Br J Ind Med 47: 99-104. 75. Wennberg M, Bergdahl IA, Stegmayr B, Hallmans G, Lundh T, et al. (2007) Fish intake, mercury, long-chain n-3 polyunsaturated fatty acids and risk of stroke in northern Sweden.Br J Nutr 98: 1038-1045. 76. Lim KM, Kim S, Kim K, Jang WH, Bae ON, et al. (2010) Low- level mercury can enhance procoagulant activity of erythrocytes: a new contributing factor for mercury-related thrombotic disease. Environ Health Perspect. 118:928-935. Kohn et al. A cardiovascular phenotype in warfarin-resistant Vkorc1 mutant rats☆. Artery Research, 2008; 2 (4): 138 DOI: 10.1016/j.artres.2008.09.002. Pinker S (New Ed 1995) The Language Instinct: The New Science of Language and Mind . London: Penguin Books Ltd. irritable bowel syndrome in children: A randomized controlled. * For The Sensitivity Hypothesis, Dandelion and Orchid Children, see research by Bruce Ellis University of Arizona, and W Thomas Boyce University of British Columbia, for example “Biological sensitivity to context: I. An evolutionary–developmental theory of the origins and functions of stress reactivity” in Development and Psychopathology. [12] Matysiak-Budnik, T. et al . Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease. J. Exp. Med. 205, 143–154 (2008). View Abstract. 13. Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998 May;64(4):353-6. Saha, SK. et al. Ultra – highly diluted plant extracts of Hydrastis canadensis and Marsdenia condurango induce epigenetic modifications and alter gene expression profiles in HeLa cells in vitro . J. Integr . Med . 13, 400–411 (2015). Christopher T. Ford, Siân Richardson, Francis McArdle, Silvina B. Lotito, Alan Crozier, Anne McArdle, Malcolm J. Jackson. Identification of (poly)phenol treatments that modulate the release of pro-inflammatory cytokines by human lymphocytes . British Journal of Nutrition , 2016; 115 (10): 1699 DOI: 10.1017/S0007114516000805. Finocchi C, Sivori G. Food as trigger and aggravating factor of migraine. Neurol Sci. 2012 May;33 Suppl 1:S77-80. Zaeem Z, Zhou L, Dilli E. Headaches: a Review of the Role of Dietary Factors. Curr Neurol Neurosci Rep. 2016 Nov;16(11):101. Rist PM, Buring JE, Kurth T. Dietary patterns according to headache and migraine status: a cross-sectional study. Cephalalgia. 2015 Aug;35(9):767-75. Pogoda JM, Gross NB, Arakaki X,et al. Severe Headache or Migraine History is Inversely Correlated With Dietary Sodium Intake: NHANES 1999-2004. Headache. 2016 Apr;56(4):688-98. Martin VT, Vij B. Diet and Headache: Part 1. Headache. 2016 Oct;56(9):1543-1552. Gibb C, Davies P, Glover V, Steiner T, Rose FC, Sandler M. Chocolate is a migraine-provoking agent. Cephalalgia. 1991;11: 93–5. Marcus DA, Scharff L, Turk D, Gourley LM. A double-blind provocative study of chocolate as a trigger of headache. Cephalalgia. 1997;17:855–62. Moffett AM, Swash M, Scott DF. Effect of chocolate in migraine: a double-blind study. J Neurol Neurosurg Psychiatry. 1974;37:445–8. Van den Eeden SK, Koepsell TD, Longstreth WT, van Belle G, Daling JR, McKnight B. Aspartame ingestion and headaches: a randomized crossover trial. Neurology. 1994;44:1787–93. Koehler SM, Glaros A. The effect of aspartame on migraine headache. Headache. 1988;28:10–4. Schiffman SS, Buckley CE, SampsonHA. Aspartame and susceptibility to headache. N Engl J Med. 1987;317:1181. Sathyapalan T, Thatcher NJ, Hammersley R, et al. Aspartame sensitivity? A double blind randomised crossover study: e0116212. PLoS One. 2015; 10. Bond DS, Roth J, Nash JM, Wing RR. Migraine and obesity: ep >Additional story: Antonio Gonzalez, Embriette Hyde, Naseer Sangwan, Jack A. Gilbert, Erik Viirre, Rob Knight. Migraines Are Correlated with Higher Levels of Nitrate-, Nitrite-, and Nitric Oxide-Reducing Oral Microbes in the American Gut Project Cohort . mSystems , October 2016 DOI: 10.1128/mSystems.00105-16 NUTRIGENETICS. 12 Sabol SZ et al. A functional polymorphism in the monoamine oxidase A gene promoter. Human Genet. 1998; 103(3): 273–279. 23. de Roos NM, Giezenaar CG, Rovers JM, Witteman BJ, Smits MG, van Hemert S. The effects of the multispecies probiotic mixture Ecologic®Barrier on migraine: results of an open-label pilot study. Benef Microbes. 2015;6(5):641-6.24. Malhotra R. Understanding migraine: Potential role of neurogenic inflammation. Ann Indian Acad Neurol. 2016 Apr-Jun;19(2):175-82.25. Lippi G, Mattiuzzi C, Cervellin G. C-reactive protein and migraine. Facts or speculations? Clin Chem Lab Med. 2014 Sep;52(9):1265-72. Nupur Bhattacharya et al. Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8 T Cell-Mediated Immunity in Colorectal Cancer . Immunity , August 2016 DOI: 10.1016/j.immuni.2016.08.008. Liana C. Del Gobbo et al. JAMA Intern Med . Published online June 27, 2016. doi:10.1001/jamainternmed.2016.2925. [10] Travis, S. & Menzies, I. Intestinal permeability: functional assessment and significance. Clin. Sci. (Lond) 82, 471–488 (1992). Investigation of 2 Types of Self-administered Acupressure for Persistent Cancer-Related Fatigue in Breast Cancer Survivors: A Randomized Clinical Trial. Theodoropoulos DS, Katzenberger DR, Jones WM, Morris DL, Her C, Cullen NA, et al. Allergen-specific sublingual immunotherapy in the treatment of migraines: a prospective study. Eur Rev Med Pharmacol Sci 2011;15:1117–21 Meng WG, Shi L, Wu LY, Lai LY, Song RX, Huang SZ. Clinical research on treatment of migraine with pine needle moxibustion. Zhongguo Zhen Jiu 2012;32:519–22. Part of: SACN: reports and position statements and Obesity and healthy eating The Scientific Advisory Committee on Nutrition (SACN) recommendations on vitamin D: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/537616/SACN_Vitamin_D_and_Health_report.pdf. Gasbarrini A, Gabrielli M, Fiore G, Candelli M, Bartolozzi F, De Luca A, Cremonini F, Franceschi F, Di Campli C, Armuzzi A, et al. Association between Helicobacter pylori cytotoxic type I CagA-positive strains and migraine with aura. 2000;20:561–565. Tunca A, Türkay C, Tekin O, Kargili A, Erbayrak M. Is Helicobacter pylori infection a risk factor for migraine? A case-control study.Acta Neurol Belg. 2004;104:161–164. Faraji F, Zarinfar N, Zanjani AT, Morteza A. The effect of Helicobacter pylori eradication on migraine: a randomized, double blind, controlled trial.Pain Physician. 2012;15:495–498 Aydinlar EI, Dikmen PY, Tiftikci A, Saruc M, Aksu M, Gunsoy HG, Tozun N. IgG-based elimination diet in migraine plus irritable bowel syndrome. 2013;53:514–525 Gabrielli M, Cremonini F, Fiore G, Addolorato G, Padalino C, Candelli M, De Leo ME, Santarelli L, Giacovazzo M, Gasbarrini A, et al. Association between migraine and Celiac disease: results from a preliminary case-control and therapeutic study.Am J Gastroenterol. 2003;98:625–629. OSTEOARTHRITIS – BEN BROWN. Cannabidiol Reduces The Anxiety Induced By Simulated Public Speaking In Treatment-Naïve Social Phobia Patients”. MM Bergamaschi, Department of Neuroscience and Behavior, School of Medicine of Ribeirão Preto, University of São Paulo, SP, Brazil. 7 Rosencranz MA et al (2005) Neural circuitry underlying the interaction between emotion and asthma symptom exacerbation. PNAS 102 (37): 13319–24. * Felitti VJ, Anda RF et al. Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults: The Adverse Childhood Experiences (ACE) Study. Am J Preventive Med May 1998, 14, 4,: 245–58. March 2017. 2. Banerjee R, Zou CG (January 2005). “Redox regulation and reaction mechanism of human cystathionine-beta-synthase: a PLP-dependent hemesensor protein”. Archives of Biochemistry and Biophysics 433 (1): 144–56. doi:10.1016/j.abb.2004.08.037. PMID 15581573. Antonio Gonzalez, Embriette Hyde, Naseer Sangwan, Jack A. Gilbert, Erik Viirre, Rob Knight. Migraines Are Correlated with Higher Levels of Nitrate-, Nitrite-, and Nitric Oxide-Reducing Oral Microbes in the American Gut Project Cohort . mSystems , October 2016 DOI: 10.1128/mSystems.00105-16. Jack A. Gilbert, Editor. mSystems, 2016: DOI: 10.1128/mSystems.00038-16. Mathias Rask-Andersen, David Martinsson, Muhammad Ahsan, Stefan Enroth, Weronica E Ek, Ulf Gyllensten, Åsa Johansson. Epigenome Wide Association Study Reveals Differential DNA Methylation in Individuals With a History of Myocardial Infarction . Human Molecular Genetics , 2016; ddw302 DOI: 10.1093/hmg/ddw302. 17. Hanai H, Iida T, Takeuchi K, et al. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol. 2006 Dec;4(12):1502-6.18. Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, et al. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging. 2014 Mar 20;9:451-819. Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C, Jirawatnotai S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care. 2012 Nov;35(11):2121-7. doi: 10.2337/dc12-0116. Food-grade TiO 2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon. 78. García Gómez M, Boffetta P, Caballero Klink JD, Español S, Gómez Quintana J (2007) [Cardiovascular mortality in mercury miners].Med Clin (Barc) 128: 766-771. BLOATING – PATRICK HOLFORD. J Calvin Coffey, D Peter O’Leary. The mesentery: structure, function, and role in disease . The Lancet Gastroenterology & Hepatology , 2016; 1 (3): 238 DOI: 10.1016/S2468-1253(16)30026-7. Kanwaljit Singh, Susan L. Connors, Eric A. Macklin, Kirby D. Smith, Jed W. Fahey, Paul Talalay, and Andrew W. Zimmerman. Sulforaphane treatment of autism spectrum disorder (ASD) . PNAS , October 13, 2014 DOI: 10.1073/pnas.1416940111. [6] Maes M, Leunis JC. Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. December 2016. EFAs REVIEW O. van de Rest, Y. Wang, L. L. Barnes, C. Tangney, D. A. Bennett, M. C. Morris. APOE 4 and the associations of seafood and long-chain omega-3 fatty acids with cognitive decline. Neurology, 2016; DOI: 10.1212/WNL.0000000000002719 Jerome Sarris, Jenifer Murphy, David Mischoulon, George I. Papakostas, Maurizio Fava, Michael Berk, Chee H. Ng. Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses. American Journal of Psychiatry, 2016; appi.ajp.2016.1 DOI: 10.1176/appi.ajp.2016.15091228. symptoms treated with a low FODMAP diet. World J Gastroenterol. 2016. 41. Hodges RE, Minich DM. Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application. J Nutr Metab. 2015;2015:760689.42. Kikuchi M, Ushida Y, Shiozawa H, et al. Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects. World J Gastroenterol. 2015 Nov 21;21(43):12457-67.43. Yang H, Xu W, Zhou Z, Liu J, Li X, Chen L, Weng J, Yu Z. Curcumin attenuates urinary excretion of albumin in type II diabetic patients with enhancing nuclear factor erythroid-derived 2-like 2 (Nrf2) system and repressing inflammatory signaling efficacies. Exp Clin Endocrinol Diabetes. 2015 Jun;123(6):360-7.44. González-Guardia L, Yubero-Serrano EM, Delgado-Lista J, et al. Effects of the Mediterranean diet supplemented with coenzyme q10 on metabolomic profiles in elderly men and women. J Gerontol A Biol Sci Med Sci. 2015 Jan;70(1):78-84. Head KA, Kelly GS. Nutrients and botanicals for treatment of stress: adrenal fatigue, neurotransmitter imbalance, anxiety, and restless sleep. Altern Med Rev. 2009;14(2):114-40. Nielsen NR, Kristensen TS, Schnohr P, et al. Perceived stress and cause-specific mortality among men and women: results from a prospective cohort study. Am J Epidemiol. 2008;168(5):481-91; discussion 92-6. Carroll BJ. Ageing, stress and the brain. Novartis Found Symp. 2002;242:26-36; discussion -45. Wikgren M, Maripuu M, Karlsson T, et al. Short telomeres in depression and the general population are associated with a hypocortisolemic state. Biol Psychiatry. 2012;71(4):294-300. Epel ES. Psychological and metabolic stress: a recipe for accelerated cellular aging? Hormones (Athens). 2009;8(1):7-22. Panossian A, Wikman G. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol. 2009;4(3):198-219. Huis in ‘t Veld JH. Gastrointestinal flora and health in man and animal. Tijdschr Diergeneeskd. 1991;116(5):232-9. Lizko NN, Silov VM, Syrych GD. Events in he development of dysbacteriosis of the intestines in man under extreme conditions. Nahrung. 1984;28(6-7):599-605. Allison TG, Williams DE, Miller TD, et al. Medical and economic costs of psychologic distress in patients with coronary artery disease. Mayo Clin Proc. 1995;70(8):734-42. Andersen BL, Farrar WB, Golden-Kreutz D, et al. Stress and immune responses after surgical treatment for regional breast cancer. J Natl Cancer Inst. 1998;90(1):30-6. Pike JL, Smith TL, Hauger RL, et al. Chronic life stress alters sympathetic, neuroendocrine, and immune responsivity to an acute psychological stressor in humans. Psychosom Med. 1997;59(4):447-57. Kyrou I, Tsigos C. Stress mechanisms and metabolic complications. Horm Metab Res. 2007;39(6):430-8. Schneiderman N, Ironson G, Siegel SD. Stress and health: psychological, behavioral, and biological determinants. Annu Rev Clin Psychol. 2005;1:607-28. Kyrou I, Tsigos C. Chronic stress, visceral obesity and gonadal dysfunction. Hormones (Athens). 2008;7(4):287-93. Azuma K, Adachi Y, Hayashi H, et al. Chronic psychological stress as a risk factor of osteoporosis. J uoeh. 2015;37(4):245-53. Singh N, Bhalla M, de Jager P, et al. An overview on ashwagandha: a rasayana (rejuvenator) of Ayurveda. Afr J Tradit Complement Altern Med. 2011;8(5 Suppl):208-13. Choudhary B, Shetty A, Langade DG. Efficacy of ashwagandha ( Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults. Ayu. 2015;36(1):63-8. Zhang ZH, Feng SH, Hu GD, et al. Effect of Rhodiola kirilowii (Regel.) Maxim on preventing high altitude reactions. A comparison of cardiopulmonary function in villagers at various altitudes. Zhongguo Zhong Yao Za Zhi. 1989;14(11):687-90, 704. Wankhede S, Langade D, Joshi K, et al. Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial. J Int Soc Sports Nutr. 2015;12:43. Kumar SS, Saraswathi P, Vijayaraghavan R. Effect of bacopa monniera on cold stress induced neurodegeneration in hippocampus of wistar rats: a histomorphometric study. J Clin Diagn Res. 2015;9(1):Af05-7. Raghav S, Singh H, Dalal PK, et al. Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment. Indian J Psychiatry. 2006;48(4):238-42. Dhanasekaran M, Tharakan B, Holcomb LA, et al. Neuroprotective mechanisms of ayurvedic antidementia botanical Bacopa monniera. Phytother Res. 2007;21(10):965-9. Chowdhuri DK, Parmar D, Kakkar P, et al. Antistress effects of bacosides of Bacopa monnieri: modulation of Hsp70 expression, superoxide dismutase and cytochrome P450 activity in rat brain. Phytother Res. 2002;16(7):639-45. Benson S, Downey LA, Stough C, et al. An acute, double-blind, placebo-controlled cross-over study of 320 mg and 640 mg doses of Bacopa monnieri (CDRI 08) on multitasking stress reactivity and mood. Phytother Res. 2014;28(4):551-9. Zhu JS, Halpern GM, Jones K. The scientific rediscovery of an ancient Chinese herbal medicine: cordyceps sinensis: part I. J Altern Complement Med. 1998;4(3):289-303. Li SP, Li P, Dong TT, et al. Anti-oxidation activity of different types of natural cordyceps sinensis and cultured cordyceps mycelia. Phytomedicine. 2001;8(3):207-12. Ng TB, Wang HX. Pharmacological actions of cordyceps, a prized folk medicine. J Pharm Pharmacol. 2005;57(12):1509-19. Liu JY, Feng CP, Li X, et al. Immunomodulatory and antioxidative activity of cordyceps militaris polysaccharides in mice. Int J Biol Macromol. 2016;86:594-8. Yan F, Wang B, Zhang Y. Polysaccharides from cordyceps sinensis mycelium ameliorate exhaustive swimming exercise-induced oxidative stress. Pharm Biol. 2014;52(2):157-61. Tianzhu Z, Shihai Y, Juan D. Antidepressant-like effects of cordycepin in a mice model of chronic unpredictable mild stress. Evid Based Complement Alternat Med. 2014;2014:438506. Cohen MM. Tulsi – Ocimum sanctum : A herb for all reasons. J Ayurveda Integr Med. 2014;5(4):251-9. Gupta P, Yadav DK, Siripurapu KB, et al. Constituents of Ocimum sanctum with antistress activity. J Nat Prod. 2007;70(9):1410-6. Rai V, Iyer U, Mani UV. Effect of Tulasi ( Ocimum sanctum ) leaf powder supplementation on blood sugar levels, serum lipids and tissue lipids in diabetic rats. Plant Foods Hum Nutr. 1997;50(1):9-16. Subramanian M, Chintalwar GJ, Chattopadhyay S. Antioxidant and radioprotective properties of an Ocimum sanctum polysaccharide. Redox Rep. 2005;10(5):257-64. Jothie Richard E, Illuri R, Bethapudi B, et al. Anti-stress activity of Ocimum sanctum : Possible effects on hypothalamic-pituitary-adrenal axis. Phytother Res. 2016;30(5):805-14. Ahmad A, Rasheed N, Chand K, et al. Restraint stress-induced central monoaminergic & oxidative changes in rats & their prevention by novel Ocimum sanctum compounds. Indian J Med Res. 2012;135(4):548-54. Bhattacharyya D, Sur TK, Jana U, et al. Controlled programmed trial of Ocimum sanctum leaf on generalized anxiety disorders. Nepal Med Coll J. 2008;10(3):176-9. Sampath S, Mahapatra SC, Padhi MM, et al. Holy basil ( Ocimum sanctum Linn.) leaf extract enhances specific cognitive parameters in healthy adult volunteers: A placebo controlled study. Indian J Physiol Pharmacol. 2015;59(1):69-77. Ahn YW. Adrenal exhaustion and fatigue due to chronic stress. J Korean Med Assoc. 2011;54(1):81-7. RESEARCH Lien Wang, Yan Zhang, Zhiwei Wang, Nian Gong, Tae Dong Kweon, Benjamin Vo, Chaoran Wang, Xiuli Zhang, Jae Yoon Chung, Amal Alachkar, Xinmiao Liang, David Z. Luo, Olivier Civelli. The Antinociceptive Properties of the Corydalis yanhusuo Extract . PLOS ONE , 2016; 11 (9): e0162875 DOI: 10.1371/journal.pone.0162875. Madhusudana Rao Chikka, Charumathi Anbalagan, Katherine Dvorak, Kyle Dombeck, Veena Prahlad. The Mitochondria-Regulated Immune Pathway Activated in the C. elegans Intestine Is Neuroprotective . Cell Reports , 2016; 16 (9): 2399 DOI: 10.1016/j.celrep.2016.07.077. MARK HOUSTON – Mercury. [11] Bijlsma, P.B. et al . Differential in vivo and in vitro intestinal permeability to lactulose and mannitol in animals and humans: a hypothesis. Gastroenterology 108, 687–696 (1995). View Abstract. Diet-Microbiome Interactions in Health Are Controlled by Intestinal Nitrogen Source Constraints. Andrew J. Holmes et al. Cell Metabolism. In Press. available online 23 November 2016. [9] Diesner, S.C. et al . Dose-dependent food allergy induction against ovalbumin under acid-suppression: a murine food allergy model. Immunol. Lett. 121, 45–51 (2008). View Full Paper. Official Statistics. National Diet and Nutrition Survey: results from Years 1 to 4 (combined) of the rolling programme for 2008 and 2009 to 2011 and 2012. From: Public Health Englandand Food Standards Agency. First published: 14 May 2014. Changes in Burnout and Satisfaction With Work-Life Balance in Physicians and the General US Working Population Between 2011 and 2014. 2 Chopra D, Tanzi RE. Supergenes. 2015. UK: Penguin. 72. Kim DS, Lee EH, Yu SD, Cha JH, Ahn SC (2005) [Heavy metal as risk factor of cardiovascular disease–an analysis of blood lead and urinary mercury].J Prev Med Public Health 38: 401-407. 41. Gonzalvo MC, Gil F, Hernández AF, Villanueva E, Pla A (1997) Inhibition of paraoxonase activity in human liver microsomes by exposure to EDTA, metals and mercurials.ChemBiol Interact 105: 169-179. Qingying Meng, Zhe Ying, Emily Noble, Yuqi Zhao, Rahul Agrawal, Andrew Mikhail, Yumei Zhuang, Ethika Tyagi, Qing Zhang, Jae-Hyung Lee, Marco Morselli, Luz Orozco, Weilong Guo, Tina M. Kilts, Jun Zhu, Bin Zhang, Matteo Pellegrini, Xinshu Xiao, Marian F. Young, Fernando Gomez-Pinilla, Xia Yang. Systems Nutrigenomics Reveals Brain Gene Networks Linking Metabolic and Brain Disorders. EBioMedicine, 2016; DOI: 10.1016/j.ebiom.2016.04.008 RESEARCH UPDATE Nathan F. Johnson, Brian T. Gold, Alison L. Bailey, Jody L. Clasey, Jonathan G. Hakun, Matthew White, Doug E. Long, David K. Powell. Cardiorespiratory fitness modifies the relationship between myocardial function and cerebral blood flow in older adults. NeuroImage, 2016; 131: 126 DOI: 10.1016/j.neuroimage.2015.05.063 Vittori Gouveia Luciana de Almeida, Cardoso Carolina Alves, de Oliveira Glaucia Maria Moraes, Rosa Glorimar, and Moreira Annie Seixas Bello. Journal of Medicinal Food. April 2016, 19(4): 337-345. doi:10.1089/jmf.2015.0075. Published in Volume: 19 Issue 4: April 13, 2016. References. 6 Freud S (Paperback ed. 1991) Introductory Lectures (1916-17). London:Penguin Books Ltd. Leder K, Hellard ME, Sinclair MI, et al. No correlation between clinical symptoms and Blastocystis hominis in immunocompetent individuals. J Gastroenterol Hepatol. 2005 Sep;20(9):1390-4. Poirier P, Wawrzyniak I, Vivarès CP, et al. New insights into Blastocystis spp.: a potential link with irritable bowel syndrome. PLoS Pathog. 2012;8(3):e1002545. Nourrisson C, Scanzi J, Pereira B, et al. Blastocystis is associated with decrease of fecal microbiota protective bacteria: comparative analysis between patients with irritable bowel syndrome and control subjects. PLoS One. 2014 Nov 3;9(11):e111868. Ragavan ND, Govind SK, Chye TT, Mahadeva S. Phenotypic variation in Blastocystis sp. ST3. Parasit Vectors. 2014 Aug 29;7:404. Vargas-Sanchez GB, Romero-Valdovinos M, Ramirez-Guerrero C, et al. Blastocystis Isolates from Patients with Irritable Bowel Syndrome and from Asymptomatic Carriers Exhibit Similar Parasitological Loads, but Significantly Different Generation Times and Genetic Variability across Multiple Subtypes. PLoS One. 2015 Apr 29;10(4):e0124006. Kuo HY, Chiang DH, Wang CC, et al. Clinical significance of Blastocystis hominis: experience from a medical center in northern Taiwan. J Microbiol Immunol Infect. 2008 Jun;41(3):222-6. Stensvold CR, Smith HV, Nagel R, et al. Eradication of Blastocystis carriage with antimicrobials: reality or delusion? J Clin Gastroenterol. 2010 Feb;44(2):85-90. Borody TJ, Warren EF, Wettstein A, et al. Eradication of Dientamoeba fragilis can resolve IBS-like symptoms. J Gastroenterol Hepatol.2002;17:A103. Nigro L, Larocca L, Massarelli L, et al. A placebocontrolled treatment trial of Blastocystis hominis infection with metronidazole. J Travel Med. 2003;10:128–30. Dinleyici EC, Eren M, Dogan N, et al. Clinical efficacy of Saccharomyces boulardii or metronidazole in symptomatic nchildren with Blastocystis hominis infection. Parasitol Res. 2011 nMar;108(3):541-5. El Wakil SS. Evaluation of the in vitro effect of Nigella sativa aqueous extract on Blastocystis hominis isolates. J Egypt Soc Parasitol. 2007 Dec;37(3):801-13. Yang LQ, Singh M, Yap EH, et al. In vitro response of Blastocystis hominis against traditional Chinese medicine. J Ethnopharmacol. 1996 Dec;55(1):35-42. Chen C, Tao C, Liu Y, et al. A Randomized Clinical Trial of Berberine Hydrochloride in Patients with Diarrhea-Predominant Irritable Bowel Syndrome. Phytother Res. 2015 Sep 24. doi: 10.1002/ptr.5475 Force M, Sparks WS, Ronzio RA. Inhibition of enteric parasites by emulsified oil of oregano in vivo. Phytother Res. 2000 May;14(3):213-4. Salem EM, Yar T, Bamosa AO, et al. Comparative study of Nigella Sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia. Saudi J Gastroenterol. 2010 Jul-Sep;16(3):207-14. Zelano, H. Jiang, G. Zhou, N. Arora, S. Schuele, J. Rosenow, J. A. Gottfried. Nasal Respiration Entrains Human Limbic Oscillations and Modulates Cognitive Function. Journal of Neuroscience, 2016; 36 (49): 12448 DOI: 10.1523/JNEUROSCI.2586-16.2016. E. F. G. Naninck, J. E. Oosterink, K.-Y. Yam, L. P. de Vries, H. Schierbeek, J. B. van Goudoever, R.-N. Verkaik-Schakel, J. A. Plantinga, T. Plosch, P. J. Lucassen, A. Korosi. Early micronutrient supplementation protects against early stress-induced cognitive impairments . The FASEB Journal , 2016; DOI: 10.1096/fj.201600834R. Castro-Marrero Jesús, Cordero Mario D., Segundo María José, Sáez-Francàs Naia, Calvo Natalia, Román-Malo Lourdes, Aliste Luisa, Fernández de Sevilla Tomás, and Alegre José. LYME and JOINTS Monica Viladomiu, Charles Kivolowitz, Ahmed Abdulhamid, Belgin Dogan, Daniel Victorio, Jim G. Castellanos, Viola Woo, Fei Teng, Nhan L. Tran, Andrew Sczesnak, Christina Chai, Myunghoo Kim, Gretchen E. Diehl, Nadim J. Ajami, Joseph F. Petrosino, Xi K. Zhou, Sergio Schwartzman, Lisa A. Mandl, Meira Abramowitz, Vinita Jacob, Brian Bosworth, Adam Steinlauf, Ellen J. Scherl, Hsin-Jung Joyce Wu, Kenneth W. Simpson, Randy S. Longman. IgA-coated E. coli enriched in Crohn’s disease spondyloarthritis promote T H 17-dependent inflammation . Science Translational Medicine , 2017; 9 (376): eaaf9655 DOI: 10.1126/scitranslmed.aaf9655. RESEARCH Cospeciation of gut microbiota with hominids. Huijuan Cao 1 , Mei Han 1 , Xun Li 1 , Shangjuan Dong 1 , Yongmei Shang 1 , Qian Wang 1 , Shu Xu 1 and Jianping Liu. BRAIN HEALTH – PATRICK HOLFORD. NEWS Jorge Vas, Koldo Santos-Rey, Reyes Navarro-Pablo, Manuela Modesto, Inmaculada Aguilar, M Ángeles Campos, José Francisco Aguilar-Velasco, Milagrosa Romero, Patricia Párraga, Vanesa Hervás, Olalla Santamaría, Carmen Márquez-Zurita, Francisco Rivas-Ruiz. Acupuncture for fibromyalgia in primary care: a randomised controlled trial. Acupuncture in Medicine, 2016; acupmed-2015-010950 DOI: 10.1136/acupmed-2015-010950. Ferric C. Fang, Anthony Bowen and Arturo Casadevall. NIH Peer Review Percentile Scores are Poorly Predictive of Grant Productivity. eLife, 2016, DOI: http://dx.doi.org/10.7554/eLife.13323. Ryan Hutchinson, Abdulhadi Akhtar, Justin Haridas, Deepa Bhat, Claus Roehrborn, Yair Lotan. Testing and referral patterns in the years surrounding the US Preventive Services Task Force recommendation against prostate-specific antigen screening . Cancer , 2016; DOI: 10.1002/cncr.30330. MITOCHONDRIA and IMMUNITY Nicole Paulin, Yvonne Döring, Sander Kooijman, Xavier Blanchet, Joana R. Viola, Renske de Jong, Manuela Mandl, Jeffrey Hendrikse, Maximilian Schiener, Philipp von Hundelshausen, Anja Vogt, Christian Weber, Khalil Bdeir, Susanna M. Hofmann, Patrick C.N. Rensen, Maik Drechsler, Oliver Soehnlein. Human Neutrophil Peptide 1 Limits Hypercholesterolemia-induced Atherosclerosis by Increasing Hepatic LDL Clearance . EBioMedicine , 2017; DOI: 10.1016/j.ebiom.2017.01.006. [17] Playford RJ, Woodman AC, Clark P, Watanapa P, Vesey D, Deprez PH, Williamson RC, Calam J. 27. Jansson G, Harms-Ringdahl M (1993) Stimulating effects of mercuric- and silver ions on the superoxide anion production in human polymorphonuclear leukocytes.Free Radic Res Commun 18: 87-98. 3. James BD, Leurgans SE, Hebert LE, Scherr PA, Yaffe K and Bennett DA. Contribution of Alzheimer disease to mortality in the United States. Neurology. 2014; 82:1045-1050. 4. http://www.alzheimersresearchuk.org/dementia-is-leading-cause-of-death-for-women-in-england-and-wales/ 5. Shriver M. A Woman’s Nation Takes on Alzheimer’s. 2010; New York, USA: Alzheimer’s Association. 6. 2014 Alzheimer’s Disease Facts and Figures. Special Report on Women and Alzheimer’s Disease. USA: Alzheimer’s Association, 2014; pp. 1-80. 7. www.alzheimers.org.uk/site/scripts/press_article.php?pressRelease > K Rosenke et al. Plasmodium parasitemia associated with increased survival in Ebola virus-infected patients. Clinical Infectious Diseases, 2016; DOI: 10.1093/cid/ciw452. 4. Kou MC, Chiou SY, Weng CY, Wang L, Ho CT, Wu MJ. Curcuminoids distinctly exhibit antioxidant activities and regulate expression of scavenger receptors and heme oxygenase-1. Mol Nutr Food Res. 2013 Sep;57(9):1598-610. 64. Valera B, Dewailly E, Poirier P (2009) Environmental mercury exposure and blood pressure among Nunavik Inuit adults.Hypertension 54: 981-986. Greenwood NN, Earnshaw A. Chemistry of the elements. 2nd. Oxford: Butterworth-Heinemann; 1997. Martin KR. The chemistry of silica and its potential health benefits. J Nutr Health Aging. 2007;11(2):94–97. [PubMed] Treguer P, Nelson DM, Van Bennekom AJ, DeMaster DJ, Leynaert A, Queguiner B. The silica balance in the world ocean: A reestimate. Science. 1995;268(5209):375–379. doi: 10.1126/science.268.5209.375. [PubMed] [Cross Ref] Frey KS, Pottery GD. Plasma silicon and radiographic bone density in weaning quarter horses fed sodium zeolite A. Equine Vet Science. 1991;12:292–296. Pavelic K, Hadzija M. In: Handbook of zeolite science and technology. 1st. Auerbach SM, Carrado KA, Dutta PK, editor. New York: Marcel Dekker; 2003. Medical applications of zeolites; pp. 1143–1174. O’Connor CI, Nielsen BD, Woodward AD, Spooner HS, Ventura BA, Turner KK. Mineral balance in horses fed two supplemental silicon sources. J Anim Physiol Anim Nutr (Berl) 2008;92(2):173–181. doi: 10.1111/j.1439-0396.2007.00724.x. [PubMed] [Cross Ref] Reffitt DM, Jugdaohsingh NR, Thompson RPH, Powel JJ. Silicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion. J Inorg Biochem. 1999;76(2):141–147. doi: 10.1016/S0162-0134(99)00126-9. [PubMed] [Cross Ref] Jugdaohsingh R, Anderson SHC, Tucker KL, Elliot H, Kiel DP, Thompson RPH, Powell JJ. Dietary silicon intake and absorption. Am J Clin Nutr. 2002;75(5):887–893. [PubMed] Smith BL. In: Trace elements in man and animals, TEMA 8. Anke M, Meissner D, Mills CF, editor. New York: Kluwer; 1993. Analysis of hair element levels by age, sex, race, and hair color; pp. 1091–1093. Austin JH. Silicon levels in human tissues. Nobel Symp. 1997. pp. 255–268. Carlisle EM. Silicon: an essential element for the chick. Science. 1972;178:619–621. doi: 10.1126/science.178.4061.619. [PubMed] [Cross Ref] Fregert S. Studies on silicon in tissues with special reference to skin. J Invest Dermatol. 1958;31(2):95–96. [PubMed] European Food Safety Authority. Opinion of the scientific panel on dietetic products, nutrition and allergies on a request from the commission related to the tolerable upper intake level of silicon. The EFSA Journal. 2004;60:1–11. Scientific Committee for Food. Nutrient and energy intakes for the European Community. Reports of the Scientific Committee for Food (Thirty-first series) Luxembourg: European Commission; 1993. Institute of Medicine, Food and Nutrition Board. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington: National Academy Press; 2000. [PubMed] Varo P, Koivistoinen P. Mineral element composition of Finnish foods. Acta Agric Scand. 1980;22:165–171. Bowen HJM, Peggs A. Determination of the silicon content of food. J Sci Food Agric. 1984;35:1225–1229. doi: 10.1002/jsfa.2740351114. [Cross Ref] Bellia JP, Birchall JD, Roberts NB. Beer: a dietary source of silicon. Lancet. 1994;343(8891):235. [PubMed] Pennington JAT. Silicon in food and diets. Food Addit Contam. 1991;8(1):97–118. doi: 10.1080/02652039109373959. [PubMed] [Cross Ref] McNaughton SA, Bolton-Smith C, Mishra GD, Jugdaohsingh R, Powell JJ. Dietary silicon intake in post-menopausal women. Br J Nut. 2005;94:813–817. doi: 10.1079/BJN20051548. [PubMed] [Cross Ref] Jugdaohsingh R, Calomme MR, Robinson K, Nielsen F, Anderson SHC, D’Haese P, Geusens P, Loveridge N, Thompson RPH, Powell JJ. Increased longitudinal growth in rats on a silicon-depleted diet. Bone. 2008;43(3):596–606. doi: 10.1016/j.bone.2008.04.014. [PMC free article] [PubMed] [Cross Ref] Van Dyck K, Van Cauwenbergh R, Robberecht H, Deelstra H. Bioavailability of silicon from food and food supplements. Fresenius J Anal Chem. 1999;363:541–544. doi: 10.1007/s002160051243. [Cross Ref] Barnett PR, Skougstad MW, Miller KJ. Chemical characterization of a public water supply. J Am Water Works Assoc. 1969;61:61–68. Sripanyakorn S, Jugdaohsingh R, Elliott H, Walker C, Mehta P, Shoukru S. The silicon content of beer and its bioavailability in healthy volunteers. Br J Nutr. 2004;91(3):403–409. doi: 10.1079/BJN20031082. [PubMed] [Cross Ref] Jugdaohsingh R, Reffitt DM, Oldham C, Day JP, Fifield LK, Thompson RPH. Oligomeric but not monomeric silica prevents aluminum absorption in humans. Am J Clin Nutr. 2000;71(4):944–949. [PubMed] Popplewell JF, King SJ, Day JP, Ackrill P, Fifield LK, Cresswell RG. et al. Kinetics of uptake and elimination of silicic acid by a human subject: a novel application of 32Si and accelerator mass spectrometry. J Inorg Biochem. 1998;69(3):177–180. doi: 10.1016/S0162-0134(97)10016-2. [PubMed] [Cross Ref] Calomme R, Cos P, D’Haese PC, Vingerhoets R, Lamberts LV, De Broe ME, In: Metal ions in biology and medicine. Volume 5. Collery P, Brätter P, Negretti De Brätter V, Khassanova L, Etienne JC, editor. Paris: John Libbey Eurotext; 1998. Absorption of silicon in healthy subjects; pp. 228–232. Berlyne GM, Adler AJ, Ferran N, Bennett S, Holt J. Silicon metabolism. I. Some aspects of renal silicon handling in normal man. Nephron. 1986;43(1):5–9. doi: 10.1159/000183709. [PubMed] [Cross Ref] European Food Safety Authority. Scientific opinion of the panel on food additives and nutrient sources added to food. The EFSA Journal. 2009;948:1–23. Budavari S. Merck index: An encyclopaedia of chemicals, drugs, and biologicals. 11th. Rahway: Merck & Co; 1989. pp. 342–343. Eisinger J, Clairet D. Effects of silicon, fluoride, etidronate and magnesium on bone mineral density: a retrospective study. Magnes Res. 1993;6(3):247–249. [PubMed] Lassus A. Colloidal silicic acid for oral and topical treatment of aged skin, fragile hair and brittle nails in females. J Int Med Res. 1993;21(4):209–215. [PubMed] Schwarz K. Silicon, fibre, and atherosclerosis. Lancet. 1977;1(8009):454–457. [PubMed] Schwarz K, Ricci BA, Punsar S, Karvonen MJ. Inverse relation of silicon in drinking water and atherosclerosis in Finland. Lancet. 1977;1(8010):538–539. [PubMed] Candy JM, Edwardson JA, Klinowski J, Oakley AE, Perry EK, Perry RH. In: Senile dementia of the Alzheimer type. Traber J, Gispen WH, editor. Heidelberg: Springer; 1985. Co-localisation of aluminum and silicon in senile plaques: implications for the neurochemical pathology of Alzheimer’s disease; pp. 183–197. Gonzalez-Munoz MJ, Meseguer I, Sanchez-Reus MI, Schultz A. Beer consumption reduces cerebral oxidation caused by aluminum toxicity by normalizing gene expression of tumor necrotic factor alpha and several antioxidant enzymes. Food Chem Toxicol. 2008;46(3):1111–1118. doi: 10.1016/j.fct.2007.11.006. [PubMed] [Cross Ref] Maehira F, Ishimine N, Miyagi I, Eguchi Y, Shimada K. Anti-diabetic effects including diabetic nephropathy of anti-osteoporotic trace minerals on diabetic mice. Nutrition. 2010;27(4):488–495. [PubMed] Dobbie JW, Smith MJB. The silicon content of body fluids. Scott Med J. 1982;27:17–19. [PubMed] Carlisle EM. In: Biochemistry of the essential ultratrace elements. Frieden E, editor. New York: Plenum Press; 1984. Silicon; pp. 257–291. Bissé E, Epting T, Beil A, Lindinger G, Lang H, Wieland H. Reference values for serum silicon in adults. Anal Biochem. 2005;337(1):130–135. doi: 10.1016/j.ab.2004.10.034. [PubMed] [Cross Ref] Van Dyck K, Robberecht H, Van Cauwenbergh R, Van Vlaslaer V, Deelstra H. Indication of silicon essentiality in humans. Serum concentrations in Belgian children and adults, including pregnant women. Biol Trace Elem Res. 2000;77(1):25–32. doi: 10.1385/BTER:77:1:25. [PubMed] [Cross Ref] Adler AJ, Berlyne GM. Silicon metabolism II. Renal handling in chronic renal failure patients. Nephron. 1986;44:36–39. [PubMed] D’ Haese PC, Shaheen FA, Huraid SO. Increased silicon levels in dialysis patients due to high silicon content in the drinking water, inadequate water treatment procedures, and concentrate contamination: a multicentre study. Nephrol Dial Transplant. 1995;10:1838–1844. [PubMed] Maehira F, Motomura K, Ishimine N, Miyagi I, Eguchi Y, Teruya S. Soluble silica and coral sand suppress high blood pressure and improve the related aortic gene expressions in spontaneously hypertensive rats. Nutr Res. 2011;31(2):147–156. doi: 10.1016/j.nutres.2010.12.002. [PubMed] [Cross Ref] Carlisle EM. The nutrition essential of silicon. Nutr Rev. 1982;40:193–198. [PubMed] Carlisle EM. Silicon: a possible factor in bone calcification. Science. 1970;167:279–280. doi: 10.1126/science.167.3916.279. [PubMed] [Cross Ref] Carlisle EM. In vivo requirement for silicon in articular cartilage and connective tissue formation in the chick. J Nutr. 1976;106:478–484. [PubMed] Carlisle EM. Biochemical and morphological changes associated with long bone abnormalities in silicon deficiency. J Nutr. 1980;110:1046–1055. [PubMed] Carlisle EM. Silicon localization and calcification in developing bone. Fed Proc. 1969;28:374. Carlisle EM. A relationship between silicon and calcium in bone formation. Fed Proc. 1970;29:565. Schwarz K, Miline DB. Growth promoting effects of silicon in rats. Nature. 1972;239(537):333–334. doi: 10.1038/239333a0. [PubMed] [Cross Ref] Seabron CD, Nielsen FH. Dietary silicon affects acid and alkaline phosphatase and 45calcium uptake in bone of rats. J Trace Elem Exp Med. 1994;7:1–11. Seabron CD, Nielsen FH. Dietary silicon and arginine affect mineral element composition of rat femur and vertebra. Biol Trace Elem Res. 2002;89:239–250. doi: 10.1385/BTER:89:3:239. [PubMed] [Cross Ref] Reffitt DM, Ogston N, Jugdaohsingh R, Cheung HFJ, Evans BAJ, Thompson RPH. et al. Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro. Bone. 2003;32(2):127–135. doi: 10.1016/S8756-3282(02)00950-X. [PubMed] [Cross Ref] Keeting PE, Oursler MJ, Wiegand KE, Bonde SK, Spelsberg TC, Riggs BL. Zeolite A increases proliferation, differentiation, and transforming growth factor production in normal adult human osteoblast like cells in vitro. J Bone Miner Res. 1992;7(11):1281–1289. [PubMed] Schutze, Oursler MJ, Nolan J, Riggs BL, Spelzberg TC. Zeolite A inhibits osteoclast mediated bone resorption in vitro. J Cell Biochem. 1995;58(1):39–46. doi: 10.1002/jcb.240580106. [PubMed] [Cross Ref] Carlisle EM. A silicon-molybdenum interrelationship in vivo. Fed Proc. 1979;38:553. Carlisle EM, Curran MJ. Effect of dietary silicon and aluminum on silicon and aluminum levels in rat brain. Alzheimer Dis Assoc Dis. 1986;1(2):83–89. [PubMed] Exley C, Korchazhkina O, Job D, Strekopytov S, Polwart A, Crome P. Non-invasive therapy to reduce the body burden of aluminium in Alzheimer’s disease. J Alzheimers Dis. 2006;10(1):17–24. [PubMed] Muller SA, Posner AS, Firschein HE. Effect of vitamin D deficiency on the crystal chemistry of bone mineral. Proc Soc Exp Biol Med. 1966;121(3):844–846. [PubMed] Carlisle EM. Silicon: a requirement in bone formation independent of vitamin D. Calcif Tissue Int. 1981;33:27–34. doi: 10.1007/BF02409409. [PubMed] [Cross Ref] Spector TD, Calomme MR, Anderson SH, Clement G, Bevan L, Demeester N. et al. Choline-stabilized orthosilicic acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial. BMC Musculoskelet Disord. 2008;9:85–95. doi: 10.1186/1471-2474-9-85. [PMC free article] [PubMed] [Cross Ref] Marcus R. Clinical review 76: the nature of osteoporosis. J Clin Endocrinol Metab. 1996;81(1):1–5. doi: 10.1210/jc.81.1.1. [PubMed] [Cross Ref] Moukarzel AA, Song M, Buchman AL, Ament ME. Silicon deficiency may be involved in bone disease of parenteral nutrition. J Am Coll Nutr. 1992;11:584. Calomme M, Geusens P, Demeester N, Behets GJ, D’Haese P, Sindambiwe JB. et al. Partial prevention of long-term femoral bone loss in aged ovariectomized rats supplemented with choline-stabilized orthosilicic acid. Calcif Tissue Int. 2006;78(4):227–232. doi: 10.1007/s00223-005-0288-0. [PubMed] [Cross Ref] Macdonald HM, Hardcastle AC, Jugdaohsingh R, Fraser WD, Reid DM, Powell JJ. Dietary silicon interacts with oestrogen to influence bone health: Evidence from the Aberdeen Prospective Osteoporosis Screening Study. Bone. 2012;50(3):681–687. doi: 10.1016/j.bone.2011.11.020. [PubMed] [Cross Ref] Barel A, Calomme M, Timchenko A, De Paepe K, Demeester N, Rogiers V, Clarys P, Vanden Berghe D. Effects of oral intake of choline-stabilized orthosilicic acid on skin, nails, and hair in women with photodamaged skin. Arch Dermatol Res. 2005;297:147–153. doi: 10.1007/s00403-005-0584-6. [PubMed] [Cross Ref] Wickett RR, Kossmann E, Barel A, Demeester N, Clarys P, Vanden Berghe D. et al. Effect of oral intake of choline-stabilized orthosilicic acid on hair tensile strength and morphology in woman with fine hair. Arch Dermatol Res. 2007;299(10):499–505. doi: 10.1007/s00403-007-0796-z. [PubMed] [Cross Ref] Perl DP, Brody AR. Alzheimer’s disease: X-ray spectrometric evidence of aluminium accumulation in neurofibrillary tangle-bearing neurons. Science. 1980;208(4441):297–309. doi: 10.1126/science.7367858. [PubMed] [Cross Ref] Perl DP. Relationship of aluminium to Alzheimer’s disease. Environ Health Perspect. 1985;63:149–153. [PMC free article] [PubMed] Candy JM, Oakley AE, Klinowski J, Carpenter TA, Perry EK, Blessed G. et al. Aluminosilicates and senile plaque formation in Alzheimer’s disease. Lancet. 1986;1(8477):354–357. [PubMed] González-Muñoz MJ, Pena A, Meseguer I. Role of beer as a possible protective factor in preventing Alzheimer’s disease. Food Chem Toxicol. 2008;46(1):49–56. doi: 10.1016/j.fct.2007.06.036. [PubMed] [Cross Ref] Edwardson JA, Moore PB, Ferrier IN, Lilley JS, Newton GWA, Barker J. et al. Effect of silicon on gastrointestinal absorption of aluminium. Lancet. 1993;342(8865):211–212. doi: 10.1016/0140-6736(93)92301-9. [PubMed] [Cross Ref] Birchall JD, Exley C, Chappell JS, Phillips MJ. Acute toxicity of aluminium to fish eliminated in silicon-rich acids waters. Nature. 1989;338:146–148. doi: 10.1038/338146a0. [Cross Ref] Hammond KE, Evans DE, Hodson MJ. Aluminium/silicon interactions in barley (Hordeum vulgare L.) seedlings. Plant Soil. 1995;173(1):89–95. doi: 10.1007/BF00155521. [Cross Ref] Exley C. A biogeochemical cycle for aluminium. J Inorg Biochem. 2003;97(1):1–7. doi: 10.1016/S0162-0134(03)00274-5. [PubMed] [Cross Ref] Birchall JD, Chappell JS. Aluminium, water chemistry, and Alzheimer’s disease. Lancet. 1989;1(8644):953. [PubMed] Taylor GA, Newens AJ, Edwardson JA, Kay DW, Forster DP. Alzheimer’s disease and the relationship between silicon and aluminium in water supplies in northern England. J Epidemiol Community Health. 1995;49(3):323–324. doi: 10.1136/jech.49.3.323. [PMC free article] [PubMed] [Cross Ref] Davenward S, Bentham P, Wright J, Crome P, Job D, Polwart A, Exley C. Silicon-rich mineral water as a non-invasive test of the ‘aluminum hypothesis’ in Alzheimer’s disease. J Alzheimers Dis. 2012. to be published. [PubMed] Exley C, Schneider C, Doucet FJ. The reaction of aluminium with silicic acid in acidic solution: an important mechanism in controlling the biological availability of aluminium. Coord Chem Rev. 2002;228(2):127–135. doi: 10.1016/S0010-8545(02)00077-2. [Cross Ref] Antonini JM, Roberts JR, Yang HM, Barger MW, Ramsey D, Castranova V. et al. Effect of silica inhalation on the pulmonary clearance of a bacterial pathogen in Fischer 344 rats. Lung. 2000;178(6):341–350. doi: 10.1007/s004080000038. [PubMed] [Cross Ref] Antonini JM, Yang HM, Ma JY, Roberts JR, Barger MW, Butterworth L. et al. Subchronic silica exposure enhances respiratory defense mechanisms and the pulmonary clearance of Listeria monocytogenes in rats. Inhal Toxicol. 2000;12(11):1017–1036. doi: 10.1080/08958370050164635. [PubMed] [Cross Ref] Kumar RK. Quantitative immunohistologic assessment of lymphocyte populations in the pulmonary inflammatory response to intratracheal silica. Am J Pathol. 1989;135(4):605–614. [PMC free article] [PubMed] Koo HC, Ryu S-H, Ahn HJ, Jung WK, Park YK, Kwon NH. et al. Immunostimulatory effects of the anionic alkali mineral complex BARODON on equine lymphocytes. Clin Vaccine Immunol. 2006;13(11):1255–1266. doi: 10.1128/CVI.00150-06. [PMC free article] [PubMed] [Cross Ref] Yoo BW, Choi SI, Kim SH, Yang SJ, Koo HC, Seo SH. et al. Immunostimulatory effects of anionic alkali mineral complex solution Barodon in porcine lymphocytes. J Vet Sci. 2001;2(1):15–24. [PubMed] Zuckermann FA, Husmann RJ. Functional and phenotypic analysis of porcine peripheral blood CD4/CD8 double-positive T cells. Immunology. 1996;87(3):500–512. [PMC free article] [PubMed] Yoo BW, Choi SI, Kim SH, Yang SJ, Koo HC, Kown NH. et al. Immunostimulatory effects of anionic alkali mineral complex solution Barodon in porcine lymphocytes. J Swine Health Prod. 2002;10:265–270. [PubMed] Park BK, Park YH, Seo KS. Lymphocyte subpopulations of peripheral blood in pigs treated with an ionized alkali mineral complex. J Vet Sci. 1999;24:67–74. Moore BR, Krakowska S, Robertson JT. Evaluation of an immunostimulant in preventing shipping related respiratory disease. J Equine Vet Sci. 1996;16:78. doi: 10.1016/S0737-0806(96)80160-2. [Cross Ref] Flaminio MJ, Rush BR, Shuman W. Immunologic function in horses after non-specific immunostimulant administration. Vet Immunol Immunopathol. 1998;63(4):303–315. doi: 10.1016/S0165-2427(98)00111-1. [PubMed] [Cross Ref] Oner G, Cirrik S, Bakan O. Effects of silica on mitochondrial functions of the proximal tubule cells in rats. Kidney Blood Press Res. 2005;28(4):203–210. doi: 10.1159/000086006. [PubMed] [Cross Ref] Libau F. Structural chemistry of silicates. Berlin: Springer; 1985. Cejka J, Heyrovsky J, editor. Zeolites and ordered mesoporous materials: progress and prospects. Amsterdam: Elsevier; 2005. (Stud Surf Sci Catal). Baerlocher C, Meier WH, Olson DH. Atlas of zeolite framework types. 6th. Amsterdam: Elsevier; 2007. Flaningen EM. In: Proceedings of the 5th international conference of zeolites. Rees LV, editor. London: Heyden; 1980. Molecular sieve zeolite technology – the first five years; pp. 760–780. Sersale R. Natural zeolites: processing, present and possible applications. Stud Surf Sci Catal. 1985;24:503–512. Naber JE, De Jong KP, Stork WHJ, Kuipers HPCE. Post industrial application of zeolite catalysis. Stud Surf Sci Catal. 1994;84:2197–2220. Pavelić K. Medical News. 1998. pp. 21–22. Colella C. Natural zeolites in environmentally friendly processes and applications. Stud Surf Sci Catal. 1999;125:641–655. Garaces JM. In: Proceedings of the 12th international conference of zeolites. Treacz MMJ, Marcus BK, Misher ME, Higgins JB, editor. Warrendale: Materials Research Society; 1999. Observations on zeolite applications; pp. 551–566. Mumpton FA. La roca magica: uses of natural zeolites in agriculture and industry. Proc Natl Acad Sci. 1999;96(7):3463–3470. doi: 10.1073/pnas.96.7.3463. [PMC free article] [PubMed] [Cross Ref] Yang RT. Adsorbents, fundamentals and applications. New York: John Wiley & Sons Inc; 2003. Loidelsbacher T. Process for manufacturing fertilizers or soil amendments from mineral and organic components. Munich: European Patent Publication (EP 0444392 B1); 1993. Rodriguez-Fuentes G, Barrios MA, Iraizoz A, Perdomo I, Cedre B. Enterex: Anti-diarrheic drug based on purified natural clinoptilolite. Zeolites. 1997;19:441–448. doi: 10.1016/S0144-2449(97)00087-0. [Cross Ref] Pavelić K, Hadzija M, Bedrica L, Pavelić J, Dikić I, Katić M. Natural zeolite clinoptilolite: new adjuvant in anticancer therapy. J Mol Med. 2001;78(12):708–720. doi: 10.1007/s001090000176. [PubMed] [Cross Ref] Katic M, Bosnjak B, Gal-Troselj K, Dikic I, Pavelic K. A clinoptilolite effects on cell media and the consequent effects on tumor cells in vitro. Front Biosci. 2006;11:1722–1732. doi: 10.2741/1918. [PubMed] [Cross Ref] Grce M, Pavelić K. Antiviral properties of clinoptilolite. Microporous and Mesoporous Materials. 2005;79:165–169. doi: 10.1016/j.micromeso.2004.10.039. [Cross Ref] Kralj M, Pavelić K. Medicine on a small scale. EMBO Rep. 2003;4(11):1008–1012. doi: 10.1038/sj.embor.7400017. [PMC free article] [PubMed] [Cross Ref] Bedioui F. Zeolite-encapsulated and clay-intercalated metal porphyrin, phthalocyanine and Schiff-base complexes as models for biomimetic oxidation catalysts: an overview. Coord Chem Rev. 1995;144:39–68. Rhee P, Brown C, Martin M, Salim A, Plurad D, Green D. et al. QuikClot use in trauma for hemorrhage control: case series of 103 documented uses. J Trauma. 2008;64(4):1093–1099. doi: 10.1097/TA.0b013e31812f6dbc. [PubMed] [Cross Ref] Adamis Z, Tatrai E, Honma K, Six E, Ungvary G. In vitro and in vivo tests for determination of the pathogenicity of quartz, diatomaceous earth, modernite and clinoptilolite. Ann Occup Hyg. 2000;44(1):67–74. [PubMed] Kogan FM, Nikitina OV. Solubility of chrysotile asbestos and basalt fibres in relation to their fibrogenic and carcinogenic action. Environ Health Perspect. 1994;102(5):205–206. doi: 10.1289/ehp.94102s5205. [PMC free article] [PubMed] [Cross Ref] Baris YI, Sahin AA, Ozemi M, Kerse I, Ozen E, Kolacan B. et al. An outbreak of pleural mesothelioma and chronic fibrosing pleurisity in the village of Karani/Urgup in Anatolia. Thorax. 1978;33:181–192. doi: 10.1136/thx.33.2.181. [PMC free article] [PubMed] [Cross Ref] Cefali EA, Nolan JC, McConnell WR, Lowe Walters D. Bioavailability of silicon and aluminium from zeolite A in dogs. Int Journ Pharm. 1996;127(2):147–154. doi: 10.1016/0378-5173(95)04110-9. [Cross Ref] Hartman RL, Fogler HS. Understanding the dissolution of zeolites. Langmuir. 2007;23(10):5477–84. doi: 10.1021/la063699g. [PubMed] [Cross Ref] Thilsing-Hansen T, Jorgensen RJ, Enemark JM, Larsen T. The effect of zeolite A supplementation in the dry period on periparturient calcium, phosphorus, and magnesium homeostasis. J Dairy Sci. 2002;85(7):1855–1862. doi: 10.3168/jds.S0022-0302(02)74259-8. [PubMed] [Cross Ref] Nielsen BD, Potter GD, Morris EL, Odom TW, Senor DM, Reynolds JA. Training distance to failure in young racing quarter horses fed sodium zeolite a. J Equine Vet Sci. 1993;13:562–567. doi: 10.1016/S0737-0806(06)81526-1. [Cross Ref] Lang KJ, Nielsen BD, Waite KL, Hill GM, Orth MW. Supplemental silicon increases plasma and milk silicon concentrations in horses. J Anim Sci. 2001;79(10):2627–2633. [PubMed] Lang KJ, Nielsen BD, Waite KL, Link J, Hill GM. Increased plasma silicon concentrations and altered bone resorption in response to sodium zeolite A supplementation in yearling horses. J Equine Vet Sci. 2001;21:550–555. doi: 10.1016/S0737-0806(01)70161-X. [Cross Ref] Turner KK, Nielsen BD, O’Connor CI, Robison DS, Rosenstein DS, Marks BP. et al. Sodium zeolite a supplementation and its impact on the skeleton of dairy calves. Biol Trace Elem Res. 2008;121(2):149–159. doi: 10.1007/s12011-007-8040-4. [PubMed] [Cross Ref] 7 Sapolsky R M Why zebras don’t get ulcers 1998 W H Freeman and Co USA. Prasad S, Gupta SC, Tyagi AK, et al. Curcumin, a component of golden spice: from bedside to bench and back. Biotechnol Adv. 2014 Nov 1;32(6):1053-64. September, 2016. http://www.nutraingredients-usa.com/Markets/Turmeric-leads-the-charge-as-herbal-sales-continue-to-bloom Li, S. Y., Yuan, W., Deng, G. R., Wang, P. et al., Chemical composition and product quality control of turmeric (Curcuma longa L.). Pharmaceutical Crops 2011, 2, 28–54. Tiffany Zee, Neelanjan Bose, Jarcy Zee, Jennifer N Beck, See Yang, Jaspreet Parihar, Min Yang, Sruthi Damodar, David Hall, Monique N O’Leary, Arvind Ramanathan, Roy R Gerona, David W Killilea, Thomas Chi, Jay Tischfield, Amrik Sahota, Arnold Kahn, Marshall L Stoller, Pankaj Kapahi. α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria . Nature Medicine , 2017; DOI: 10.1038/nm.4280. Kukkonen K, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R, Poussa T,Tuure T, Kuitunen M (2007) Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: A randomized, double-blind, placebo-controlled Journal of Allergy and Clinical Immunology 119: 192-8 . Stenson WF, Newberry R, Lorenz R, Baldus C, Civitelli R. Increased prevalence of celiac disease and need for routine screening among patients with osteoporosis. Archives of Internal Medicine; vol. 165, pp. 393-399, Feb. 28, 2005. doi: 10.1001/archinte.165.4.393. 67. Moszczyski P (2006) [Mercury and the risk of coronary heart disease].PrzeglLek 63 Suppl 7: 84-87. PANEL: Antje Brüser, Angela Schulz, Sven Rothemund, Albert Ricken, Davide Calebiro, Gunnar Kleinau, Torsten Schöneberg. The Activation Mechanism of Glycoprotein Hormone Receptors with Implications in the Cause and Therapy of Endocrine Diseases. Journal of Biological Chemistry, 2016; 291 (2): 508 DOI: 10.1074/jbc.M115.701102. 1. Ginsburg GS, Willard HF. Genomic and personalized medicine: foundations and applications. Transl Res. 2009 Dec;154(6):277-87. 2. Minich DM, Bland JS. Personalized lifestyle medicine: relevance for nutrition and lifestyle recommendations. ScientificWorldJournal. 2013 Jun 26;2013:129841. 3. Fenech M, El-Sohemy A, Cahill L, et al. Nutrigenetics and nutrigenomics: viewpoints on the current status and applications in nutrition research and practice. J Nutrigenet Nutrigenomics. 2011;4(2):69-89. 4. Sykiotis GP, Kalliolias GD, Papavassiliou AG. Pharmacogenetic principles in the Hippocratic writings. J Clin Pharmacol. 2005 Nov;45(11):1218-20. 5. Jaiswal YS, Williams LL, A glimpse of Ayurveda e The forgotten history and principles of Indian traditional medicine, Journal of Traditional and Complementary Medicine (2016), http://dx.doi.org/10.1016/j.jtcme.2016.02.002 6. Gupta PD. Pharmacogenetics, pharmacogenomics and ayurgenomics for personalized medicine: a paradigm shift. Indian J Pharm Sci. 2015 Mar-Apr;77(2):135-41. 7. Prasher B, Gibson G, Mukerji M. Genomic insights into ayurvedic and western approaches to personalized medicine. J Genet. 2016 Mar;95(1):209-28. 8. Rotti H, Mallya S, Kabekkodu SP, et al. DNA methylation analysis of phenotype specific stratified Indian population. J Transl Med. 2015 May 8;13:151. 9. Govindaraj P, Nizamuddin S, Sharath A, et al. Genome-wide analysis correlates Ayurveda Prakriti. Sci Rep. 2015 Oct 29;5:15786. 10. Prasher B, Negi S, Aggarwal S, et al. Whole genome expression and biochemical correlates of extreme constitutional types defined in Ayurveda. J Transl Med. 2008 Sep 9;6:48. 11. Mahalle, N. P., Kulkarni, M. V., Pendse, N. M. & Naik, S. S. Association of constitutional type of Ayurveda with cardiovascular risk factors, inflammatory markers and insulin resistance. J. Ayurveda Integr. Med. 3, 150–157 (2012). 12. DuBroff R, Lad V, Murray-Krezan C. A Prospective Trial of Ayurveda for Coronary Heart Disease: A Pilot Study. Altern Ther Health Med. 2015 Sep-Oct;21(5):52-62. 13. Rasmussen LB, Mikkelsen K, Haugen M, et al. Treatment of fibromyalgia at the Maharishi Ayurveda Health Centre in Norway. A six-month follow-up study. Clin Exp Rheumatol. 2009 Sep-Oct;27(5 Suppl 56):S46-50. 14. Patel KB, Patel M, Mehta CS, Gupta S, Kessler CS. Ayurvedic management of ulcerative colitis–a non-randomized observational clinical study. Forsch Komplementmed. 2013;20(2):144-7. 15. Banerjee S, Debnath P, Debnath PK. Ayurnutrigenomics: Ayurveda-inspired personalized nutrition from inception to evidence. J Tradit Complement Med. 2015 Mar 24;5(4):228-33. Nichols GA, Hillier TA, Brown JB. Normal fasting plasma glucose and risk of type 2 diabetes diagnosis. Am J Med 2008;121:519 –524. 44. Torres AD, Rai AN, Hardiek ML (2000) Mercury intoxication and arterial hypertension: report of two patients and review of the literature.Pediatrics 105: E34. 40. Lu KP, Zhao SH, Wang DS (1990) The stimulatory effect of heavy metal cations on proliferation of aortic smooth muscle cells.Sci China B 33: 303-310. FUNCTIONAL MEDICINE – BEN BROWN. A Meta-Analysis of Randomized Controlled Trials and Prospective Cohort Studies of Eicosapentaenoic and Docosahexaenoic Long-Chain Omega-3 Fatty Acids and Coronary Heart Disease Risk. Dominik D. Alexander et al. Open Access . DOI: http://dx.doi.org/10.1016/j.mayocp.2016.10.018. Arthritis Rheumatol. 2016 Jun 23. doi: 10.1002/art.39785. [Epub ahead of print] LEARNING ZONE – the Sensitivity Gene. Dethlefsen, L., & Relman, D. (2010). Colloquium Paper: Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation Proceedings of the National Academy of Sciences, 108 (Supplement_1), 4554-4561 DOI: 10.1073/pnas.1000087107. 23. Singhal RK, Anderson ME, Meister A (1987) Glutathione, a first line of defense against cadmium toxicity. FASEB J 1: 220-223. 24. Seppänen K, Kantola M, Laatikainen R, Nyyssönen K, Valkonen VP, et al. (2000) Effect of supplementation with organic selenium on mercury status as measured by mercury in pubic hair.J Trace Elem Med Biol 14: 84-87. Egner PA , et al . (2014) Rapid and sustainable detoxication of airborne pollutants by. 60. Wiggers GA, Peçanha FM, Briones AM, Pérez-Girón JV, Miguel M, et al. (2008) Low mercury concentrations cause oxidative stress and endothelial dysfunction in conductance and resistance arteries.Am J Physiol Heart CircPhysiol 295: H1033-1033H1043. Taking a “good” look at free radicals in the aging process. February 2016. Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in Chronic Fatigue Syndrome? Antioxidants & Redox Signaling. March 10, 2015, 22(8): 679-685. doi:10.1089/ars.2014.6181. OSTEOPOROSIS J. Paccou et al. Ischemic heart disease is associated with lower cortical volumetric bone mineral density of distal radius. Osteoporosis International July 2015, Volume 26, Issue 7, pp 1893-1901. http://link.springer.com/article/10.1007/s00198-015-3132-z. Nina Kim, Thomas H. Thatcher, Patricia J. Sime, Richard P. Phipps. Corticosteroids inhibit anti-IgE activities of specialized proresolving mediators on B cells from asthma patients . JCI Insight , 2017; 2 (3) DOI: 10.1172/jci.insight.88588. Jenny L. Donovan, et al. Patient-Reported Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer . New England Journal of Medicine , 2016; DOI: 10.1056/NEJMoa1606221. 54. MacIntosh DL, Williams PL, Hunter DJ, Sampson LA, Morris SC, et al. (1997) Evaluation of a food frequency questionnaire-food composition approach for estimating dietary intake of inorganic arsenic and methylmercury. Cancer Epidemiol Biomarkers Prev 6:1043-1050. Effectiveness of Stevia Rebaudiana Whole Leaf Extract Against the Various Morphological Forms of Borrelia Burgdorferi in Vitro. Fructan content of commonly consumed wheat, rye and gluten-free breads. Whelan K1, Abrahmsohn O, David GJ, Staudacher H, Irving P, Lomer MC, Ellis PR. Int J Food Sci Nutr. 2011 Aug;62(5):498-503. doi: 10.3109/09637486.2011.553588. Epub 2011 Mar 23. Randomised placebo-controlled trials of individualised homeopathic treatment: systematic review and meta-analysis. Robert T Mathie et al. Systematic Rev, 2014, 3 :142. DOI: 10.1186/2046-4053-3-142. 18 Pandolfo G et al. Association of the COMT synonymous polymorphism Leu136Leu and missense variant Vak158Met with mood disorders. J Affect Disord. 2015; 177:108-113. 28. Maghbooli M, Golipour F, Moghimi Esfandabadi A, Yousefi M. Comparison between the efficacy of ginger and sumatriptan in the ablative treatment of the common migraine. Phytother Res. 2014 Mar;28(3):412-5. References. Pegorie, D.W. Denning, W. Welfare. Estimating the burden of invasive and serious fungal disease in the United Kingdom. Journal of Infection, 2016; DOI: 10.1016/j.jinf.2016.10.005 Ren, C. Luo, Y. Feng, X. Yao, Z. Shi, F. Liang, J. X. Kang, J.-B. Wan, Z. Pei, H. Su. Omega-3 polyunsaturated fatty acids promote amyloid- clearance from the brain through mediating the function of the glymphatic system . The FASEB Journal , 2016; DOI: 10.1096/fj.201600896 Yuan, G. Wei, Y. You, Y. Huang, H. J. Lee, M. Dong, J. Lin, T. Hu, H. Zhang, C. Zhang, H. Zhou, R. Ye, X. Qi, B. Zhai, W. Huang, S. Liu, W. Xie, Q. Liu, X. Liu, C. Cui, D. Li, J. Zhan, J. Cheng, Z. Yuan, W. Jin. Rutin ameliorates obesity through brown fat activation . The FASEB Journal , 2016; DOI: 10.1096/fj.201600459RR. 1. Sies H, Stahl W, Sevanian A. Nutritional, dietary and postprandial oxidative stress. J Nutr. 2005 May;135(5):969-72. 21. Hishikawa N, Takahashi Y, Amakusa Y, Tanno Y, Tuji Y, Niwa H, Murakami N, Krishna UK. Effects of turmeric on Alzheimer’s disease with behavioral and psychological symptoms of dementia. Ayu. 2012 Oct;33(4):499-504. RESEARCH Francesco Foroni, Giulio Pergola, Raffaella Ida Rumiati. Food colour is in the eye of the beholder: the role of human trichromatic vision in food evaluation. Scientific Reports , 2016; 6: 37034 DOI: 10.1038/srep37034. Violi F, et al. Extra virgin olive oil use is associated with improved post-prandial blood glucose and LDL cholesterol in healthy subjects. Nutr Diabetes. 2015 Jul 20;5:e172. Wien M, et al. A randomized 3×3 crossover study to evaluate the effect of Hass avocado intake on post-ingestive satiety, glucose and insulin levels, and subsequent energy intake in overweight adults. Nutr J. 2013 Nov 27;12:155. Beejmohun V, et al. Acute effect of Ceylon cinnamon extract on postprandial glycemia: alpha-amylase inhibition, starch tolerance test in rats, and randomized crossover clinical trial in healthy volunteers. BMC Complement Altern Med. 2014 Sep 23;14:351. Shimabukuro M, et al. Effects of the brown rice diet on visceral obesity and endothelial function: the BRAVO study. Br J Nutr. 2014 Jan 28;111(2):310-20. Thompson SV, Winham DM, Hutchins AM. Bean and rice meals reduce postprandial glycemic response in adults with type 2 diabetes: a cross-over study. Nutr J. 2012 Apr 11;11:23. Josse AR, Kendall CW, Augustin LS, Ellis PR, Jenkins DJ. Almonds and postprandial glycemia–a dose-response study. Metabolism. 2007 Mar;56(3):400-4. Ostman E, et al. Vinegar supplementation lowers glucose and insulin responses and increases satiety after a bread meal in healthy subjects. Eur J Clin Nutr. 2005 Sep;59(9):983-8. 21 Simpson EH et al. Genetic variation in COMT activity impacts learning and dopamine release capacity in the striatum. Learn Mem. 2014; 21(4): 205–214. 2. Cline JC. Nutritional aspects of detoxification in clinical practice. Altern Ther Health Med. 2015 May-Jun;21(3):54-62.3. Klein AV, Kiat H. Detox diets for toxin elimination and weight management: a critical review of the evidence. J Hum Nutr Diet. 2015 Dec;28(6):675-86.4. Edwards TM, Myers JP. Environmental exposures and gene regulation in disease etiology. Environ Health Perspect. 2007 Sep;115(9):1264-70.5. Crinnion WJ. The CDC fourth national report on human exposure to environmental chemicals: what it tells us about our toxic burden and how it assist environmental medicine physicians. Altern Med Rev. 2010 Jul;15(2):101-9.6. Tyrrell J, Melzer D, Henley W, Galloway TS, Osborne NJ. Associations between socioeconomic status and environmental toxicant concentrations in adults in the USA: NHANES 2001-2010. Environ Int. 2013 Sep;59:328-35.7. Di Renzo GC, Conry JA, Blake J, et al. International Federation of Gynecology and Obstetrics opinion on reproductive health impacts of exposure to toxic environmental chemicals. Int J Gynaecol Obstet. 2015 Dec;131(3):219-25.8. Goldman LR, Koduru S. Chemicals in the environment and developmental toxicity to children: a public health and policy perspective. Environ Health Perspect. 2000 Jun;108 Suppl 3:443-8.9. Chevalier N, Fénichel P. Endocrine disruptors: new players in the pathophysiology of type 2 diabetes? Diabetes Metab. 2015 Apr;41(2):107-15.10. Heindel JJ, Newbold R, Schug TT. Endocrine disruptors and obesity. Nat Rev Endocrinol. 2015 Nov;11(11):653-61. 11. Zeliger HI. Lipophilic chemical exposure as a cause of cardiovascular disease. Interdiscip Toxicol. 2013 Jun;6(2):55-62.12. Teitelbaum SL, Belpoggi F, Reinlib L. Advancing research on endocrine disrupting chemicals in breast cancer: Expert panel recommendations. Reprod Toxicol. 2015 Jul;54:141-7. 13. Barragán-Martínez C, Speck-Hernández CA, Montoya-Ortiz G, Mantilla RD, Anaya JM, Rojas-Villarraga A. Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis. PLoS One. 2012;7(12):e51506.14. Brown BI. Chronic fatigue syndrome: a personalized integrative medicine approach. Altern Ther Health Med. 2014 Jan-Feb;20(1):29-40. 15. Wang N, Zhou Y, Fu C, Wang H, Huang P, Wang B, Su M, Jiang F, Fang H, Zhao Q, Chen Y, Jiang Q. Influence of Bisphenol A on Thyroid Volume and Structure Independent of Iodine in School Children. PLoS One. 2015 Oct 23;10(10):e0141248.16. Akın L, Kendirci M, Narin F, Kurtoglu S, Saraymen R, Kondolot M, Koçak S, Elmali F. The endocrine disruptor bisphenol A may play a role in the aetiopathogenesis of polycystic ovary syndrome in adolescent girls. Acta Paediatr. 2015 Apr;104(4):e171-7. 17. Anger DL, Foster WG. The link between environmental toxicant exposure and endometriosis. Front Biosci. 2008 Jan 1;13:1578-93.18. Tzivian L, Winkler A, Dlugaj M, et al. Effect of long-term outdoor air pollution and noise on cognitive and psychological functions in adults. Int J Hyg Environ Health. 2015 Jan;218(1):1-11.19. Genuis SJ, Kelln KL. Toxicant exposure and bioaccumulation: a common and potentially reversible cause of cognitive dysfunction and dementia. Behav Neurol. 2015;2015:620143. 20. Genuis SJ. Elimination of persistent toxicants from the human body. Hum Exp Toxicol. 2011 Jan;30(1):3-18. 21. Jandacek RJ, Tso P. Factors affecting the storage and excretion of toxic lipophilic xenobiotics. Lipids. 2001 Dec;36(12):1289-305.22. Jandacek RJ, Heubi JE, Buckley DD, Khoury JC, Turner WE, Sjödin A, Olson JR, Shelton C, Helms K, Bailey TD, Carter S, Tso P, Pavuk M. Reduction of the body burden of PCBs and DDE by dietary intervention in a randomized trial. J Nutr Biochem. 2014 Apr;25(4):483-8. 20 Hallehand H et al. Association between catechol-O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in adults. Am J Med Genet B Neuropsychiatr Genet. 2009;150B(3):403-410. SACN vitamin D and health report, from. Fulltext PDF (674 Kb) Free Access at www.karger.com/Article/FullText/445350. October 2016. Dagfinn Aune, NaNa Keum, Edward Giovannucci, Lars T. Fadnes, Paolo Boffetta, Darren C. Greenwood, Serena Tonstad, Lars J. Vatten, Elio Riboli, Teresa Norat. Nut consumption and risk of cardiovascular disease, total cancer, all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis of prospective studies . BMC Medicine , 2016; 14 (1) DOI: 10.1186/s12916-016-0730-3. 8. Madhu K, Chanda K, Saji MJ. Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trial. Inflammopharmacology. 2013 Apr;21(2):129-36.9. Metzler M, Pfeiffer E, Schulz SI, Dempe JS. Curcumin uptake and metabolism. Biofactors. 2013 Jan-Feb;39(1):14-20.10. Wang K, Qiu F. Curcuminoid metabolism and its contribution to the pharmacological effects. Curr Drug Metab. 2013 Sep;14(7):791-806. 61. Al-Saleh I, Shinwari N, Mashhour A, Mohamed Gel-D, Ghosh MA, et al. (2006) Cadmium and mercury levels in Saudi women and its possible relationship with hypertension.Biol Trace Elem Res 112: 13-29. Ramon Estruch, Miguel Angel Martínez-González, Dolores Corella, Jordi Salas-Salvadó, Montserrat Fitó, Gemma Chiva-Blanch, Miquel Fiol, Enrique Gómez-Gracia, Fernando Arós, José Lapetra, Lluis Serra-Majem, Xavier Pintó, Pilar Buil-Cosiales, José V Sorlí, Miguel A Muñoz, Josep Basora-Gallisá, Rosa María Lamuela-Raventós, Mercè Serra-Mir, Emilio Ros. Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: a prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial. The Lancet Diabetes & Endocrinology, 2016; DOI: 10.1016/S2213-8587(16)30085-7 Moran Yassour et al. Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability. Science Translational Medicine, 2016 DOI: 10.1126/scitranslmed.aad0917 . Franziska Faber, Lisa Tran, Mariana X. Byndloss, Christopher A. Lopez, Eric M. Velazquez, Tobias Kerrinnes, Sean-Paul Nuccio, Tamding Wangdi, Oliver Fiehn, Renée M. Tsolis, Andreas J. Bäumler. Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion. Nature, 2016; DOI: 10.1038/nature18597 . Catherine R. Marinac, Sandahl H. Nelson, Caitlin I. Breen, Sheri J. Hartman, Loki Natarajan, John P. Pierce, Shirley W. Flatt, Dorothy D. Sears, Ruth E. Patterson. Prolonged Nightly Fasting and Breast Cancer Prognosis. JAMA Oncology, 2016; DOI: 10.1001/jamaoncol.2016.0164. Sara Vieira-Silva, Gwen Falony, Youssef Darzi, Gipsi Lima-Mendez, Roberto Garcia Yunta, Shujiro Okuda, Doris Vandeputte, Mireia Valles-Colomer, Falk Hildebrand, Samuel Chaffron, Jeroen Raes. Species–function relationships shape ecological properties of the human gut microbiome. Nature Microbiology, 2016; 16088 DOI: 10.1038/nmicrobiol.2016.88. Lakshmi Krishnamoorthy, Joseph A Cotruvo, Jefferson Chan, Harini Kaluarachchi, Abigael Muchenditsi, Venkata S Pendyala, Shang Jia, Allegra T Aron, Cheri M Ackerman, Mark N Vander Wal, Timothy Guan, Lukas P Smaga, Samouil L Farhi, Elizabeth J New, Svetlana Lutsenko, Christopher J Chang. Copper regulates cyclic-AMP-dependent lipolysis. Nature Chemical Biology, 2016; DOI: 10.1038/nchembio.2098 Bredesen Dale E. Bredesen, Edwin C. Amos3, Jonathan Canick4, Mary Ackerley5, Cyrus Raji6, Milan Fiala7, and Jamila Ahdidan, Aging 2016, 8 (6): online at http://www.impactaging.com/papers/v8/n6/full/100981.html. [2] Ivanov II, & Littman DR (2010). Segmented filamentous bacteria take the stage. Mucosal immunology, 3 (3), 209-12 PMID: 20147894. 69. Wennberg M, Strömberg U, Bergdahl IA, Jansson JH, Kauhanen J, et al. (2012) Myocardial infarction in relation to mercury and fatty acids from fish: a risk-benefit analysis based on pooled Finnish and Swedish data in men.Am J ClinNutr 96: 706-713. 7. Monnier L, Mas E, Ginet C, Michel F, Villon L, Cristol JP, Colette C. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA. 2006 Apr 12;295(14):1681-7. Mayo Clinic Proceedings, January 2017, Volume 92, Issue 1, Pages 15–29. 34. Naganuma A, Koyama Y, Imura N (1980) Behavior of methylmercury in mammalian erythrocytes.ToxicolApplPharmacol 54: 405-410. From Sample to Multi-Omics Conclusions in under 48 Hours. Robert A. Quinn, Jose A. Navas-Molina, Embriette R. Hyde, Se Jin Song, Yoshiki Vázquez-Baeza, Greg Humphrey, James Gaffney, Jeremiah J. Minich, Alexey V. Melnik, Jakob Herschend, Jeff DeReus, Austin Durant, Rachel J. Dutton, Mahdieh Khosroheidari, Clifford Green, Ricardo da Silva, Pieter C. Dorrestein, Rob Knight. Robert S. Thompson, Rachel Roller, Agnieszka Mika, Benjamin N. Greenwood, Rob Knight, Maciej Chichlowski, Brian M. Berg, Monika Fleshner. Dietary Prebiotics and Bioactive Milk Fractions Improve NREM Sleep, Enhance REM Sleep Rebound and Attenuate the Stress-Induced Decrease in Diurnal Temperature and Gut Microbial Alpha Diversity . Frontiers in Behavioral Neuroscience , 2017; 10 DOI: 10.3389/fnbeh.2016.00240. Pallauf, K., Giller, K., Huebbe, P. & Rimbach, G. (2013) Nutrition and healthy ageing: calorie restriction or polyphenol-rich “MediterrAsian” diet? Oxid Med Cell Longev, 2013pp. 707421. Ciccia F, Guggino G, Rizzo A, Alessandro R, Luchetti MM, Milling S, Saieva L, Cypers H, Stampone T, Di Benedetto P, Gabrielli A, Fasano A, Elewaut D, Triolo G. NEW RELEASES An Exploratory Investigation of Endotoxin Levels in Novice Long Distance Triathletes, and the Effects of a Multi-Strain Probiotic/Prebiotic, Antioxidant Intervention. Robert K. Naviaux et al. Metabolic features of chronic fatigue syndrome. PNAS 2016, vol. 113: 37, E5472–E5480. doi: 10.1073/pnas.1607571113. 3. O’Keefe JH, Gheewala NM, O’Keefe JO. Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health. J Am Coll Cardiol. 2008 Jan 22;51(3):249-55. An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis. Chen J 1 , Wright K 2 , Davis JM 2 , Jeraldo P 3 , Marietta EV 4 , Murray J 4 , Nelson H 3 , Matteson EL 2 , Taneja V 5 . Jandacek RJ, Genuis SJ. An assessment of the intestinal lumen as a site for intervention in reducing body burdens of organochlorine compounds. ScientificWorldJournal. 2013;2013:205621. 43. Boffetta P, Sällsten G, Garcia-Gómez M, Pompe-Kirn V, Zaridze D, et al. (2001) Mortality from cardiovascular diseases and exposure to inorganic mercury.Occup Environ Med 58: 461-466. Nutritional approaches to combat oxidative stress in Alzheimer’s disease. Butterfield D, Castegna A, Pocernich C, Drake J, Scapagnini G, Calabrese V. J Nutr Biochem. 2002 Aug;13(8):444. Zhongyuan Guo, Nicole J. Martucci, Fabiola Moreno-Olivas, Elad Tako, Gretchen J. Mahler. Titanium dioxide nanoparticle ingestion alters nutrient absorption in an in vitro model of the small intestine . NanoImpact , 2017; 5: 70 DOI: 10.1016/j.impact.2017.01.002. 1. Johannes CB, Le TK, Zhou XL, Johnston JA, Dworkin RH. The prevalence of chronic pain in United States adults results of an internet-based survey. J Pain. 2010;11:1230–1239. 2. Kroenke K, Krebs EE, Bair MJ. Pharmacotherapy of chronic pain: a synthesis of recommendations from systematic reviews. Gen Hosp Psychiatry. 2009;31:206–219. 3. Katz WA, Barkin RL. Dilemmas in chronic/persistent pain management. Am J Ther. 2008 May-Jun;15(3):256-64. 4. Mandiakis and Gray, 2000 N. Mandiakis and A. Gray, The economic burden of low back pain in the United Kingdom, Pain 84 (1) (2000), pp. 95-103. 5. Coxib and Traditional NSAID Trialists’ (CNT) Collaboration. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet. 2013;382:769–779. 6. da Costa BR, Reichenbach S, Keller N, et al. Eff ectiveness of non-steroidal anti-infl ammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis. Lancet 2016; published online March 17. 7. Moore N, et al. Does paracetamol still have a future in osteoarthritis? Lancet 2016; published online March 17. 8. Staud R. Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions. Expert Rev Neurother. 2012 May;12(5):577-85. 9. Staud R. Evidence for shared pain mechanisms in osteoarthritis, low back pain, and fibromyalgia. Curr Rheumatol Rep. 2011 Dec;13(6):513-20. 10. Muley MM, Krustev E, McDougall JJ. Preclinical Assessment of Inflammatory Pain. CNS Neurosci Ther. 2016 Feb;22(2):88-101. 11. Scrivo R, Vasile M, Bartosiewicz I, Valesini G. Inflammation as “common soil” of the multifactorial diseases. Autoimmun Rev. 2011 May;10(7):369-74. 12. Egger G, Dixon J. Obesity and chronic disease: always offender or often just accomplice? Br J Nutr. 2009 Oct;102(8):1238-42. 13. Arseneau L. Integrative and Functional Medicine in Refractive, Chronic, Complex, Pain Syndromes. Natural Medicine Journal, March 2016 Vol. 8 Issue 3. http://goo.gl/wVIFX3) 14. Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol. 2009 Jan;41(1):40-59. 15. Hamidpour R, et al. Frankincense ( rǔ xiāng; boswellia species): from the selection of traditional applications to the novel phytotherapy for the prevention and treatment of serious diseases. J Tradit Complement Med. 2013 Oct;3(4):221-6. 16. Calder PC. Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance. Biochim Biophys Acta. 2015 Apr;1851(4):469-84. 17. Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, Buntragulpoontawee M, Lukkanapichonchut P, Chootip C, Saengsuwan J, Tantayakom K, Laongpech S. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging. 2014 Mar 20;9:451-8. 18. Ramsden CE, et al. Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial. Pain. 2013 Nov;154(11):2441-51. 19. Kaartinen K, Lammi K, Hypen M, Nenonen M, Hanninen O, Rauma AL. Vegan diet alleviates fibromyalgia symptoms. Scand J Rheumatol. 2000;29(5):308-13. 20. Clinton CM, et al. Whole-foods, plant-based diet alleviates the symptoms of osteoarthritis. Arthritis. 2015;2015:708152. 21. Kjeldsen-Kragh J, Haugen M, Borchgrevink CF, Laerum E, Eek M, Mowinkel P, Hovi K, Førre O. Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis. Lancet. 1991 Oct 12;338(8772):899-902. 22. Maes M, Leunis JC. Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. Neuro Endocrinol Lett. 2008 Dec;29(6):902-10. 23. Irwin MR, Olmstead R, Carrillo C, Sadeghi N, Breen EC, Witarama T, Yokomizo M, Lavretsky H, Carroll JE, Motivala SJ, Bootzin R, Nicassio P. Cognitive behavioral therapy vs. Tai Chi for late life insomnia and inflammatory risk: a randomized controlled comparative efficacy trial. Sleep. 2014 Sep 1;37(9):1543-52. 24. Cordero MD, Alcocer-Gómez E, de Miguel M, Culic O, Carrión AM, Alvarez-Suarez JM, Bullón P, Battino M, Fernández-Rodríguez A, Sánchez-Alcazar JA. Can coenzyme q10 improve clinical and molecular parameters in fibromyalgia? Antioxid Redox Signal. 2013 Oct 20;19(12):1356-61. 25. Okifuji A, Hare BD. The association between chronic pain and obesity. J Pain Res. 2015 Jul 14;8:399-408. 26. Licciardone JC, Kearns CM, Minotti DE. Outcomes of osteopathic manual treatment for chronic low back pain according to baseline pain severity: results from the OSTEOPATHIC Trial. Man Ther. 2013 Dec;18(6):533-40. ME/CFS * #MEAction petition http://my.meaction.net/petitions/pace-trial-needs-review-now * The PACE Lancet paper http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(11)60096-2/fulltext * Open letter to The Lancet from 42 scientists and doctors http://www.virology.ws/2016/02/10/open-letter-lancet-again/ * Dr David Tuller’s article on the PACE trial http://www.virology.ws/2015/10/21/trial-by-error-i/ September 2016. Timothy R. Sampson et al. Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease. Cell, December 2016 DOI: 10.1016/j.cell.2016.11.018. First published: 21 July 2016. [18] Langmead L, Dawson C, Hawkins C, Banna N, Loo S, Rampton DS. Antioxidant effects of herbal therapies used by patients with inflammatory bowel disease: an in vitro study. Aliment Pharmacol Ther. 2002 Feb;16(2):197-205. View Abstract. G J McBean, M G López and F K Wallner. Redox-based therapeutics in neurodegenerative disease . British Journal of Pharmacology , 1 AUG 2016 DOI: 10.1111/bph.13551. Osteoporosis Associated with Neutralizing Autoantibodies against Osteoprotegerin Philip L. Riches, M.R.C.P., Euan McRorie, F.R.C.P., William D. Fraser, Ph.D., F.R.C.Path., Catherine Determann, B.Med.Sci., Rob van’t Hof, Ph.D., and Stuart H. Ralston, M.D. N Engl J Med 2009; 361:1459-1465 October 8, 2009 DOI: 10.1056/NEJMoa0810925. [14] Pohjavuori E, Viljanen M, Korpela R, Kuitunen M, Tiittanen M, Vaarala O, Savilahti E. Lactobacillus GG effect in increasing IFN-gamma production in infants with cow’s milk allergy. J Allergy Clin Immunol. 2004 Jul;114(1):131-6. View Abstract. 37. Lin TH, Huang YL, Huang SF (1996) Lipid peroxidation in liver of rats administrated with methyl mercuric chloride.Biol Trace Elem Res 54: 33-41. Bredesen DE. Reversal of cognitive decline: A novel therapeutic program. Aging 2014; 6:707-17. Doi: 10.18632/aging.100690. prebiotic on faecal microbiota and symptoms in irritable bowel syndrome. Aliment Pharmacology and Therapeutics. 2009 Mar; 29(5):508–18. Al-Karawi D, Al Mamoori DA, Tayyar Y. The Role of Curcumin Administration in Patients with Major Depressive Disorder: Mini Meta-Analysis of Clinical Trials.Phytother Res. 2016 Feb;30(2):175-83. Chassaing B, et al. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature. 2015 Mar 5;519(7541):92-6 Ng TP, Chiam PC, Lee T, Chua HC, Lim L, Kua EH. Curry consumption and cognitive function in the elderly. Am J Epidemiol. 2006;164:898–906. MIGUEL TORIBIO-MATEAS Further reading – Part 1 1. Chow, H. M. & Herrup, K. (2015) Genomic integrity and the ageing brain. Nat Rev Neurosci, 16(11) pp. 672-84. 2. St Laurent, G., 3rd, Hammell, N. & Mccaffrey, T. A. (2010) A LINE-1 component to human aging: do LINE elements exact a longevity cost for evolutionary advantage? Mech Ageing Dev, 131(5) pp. 299-305. 3. Ames, B. N., Atamna, H. & Killilea, D. W. (2005) Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging. Mol Aspects Med, 26(4-5) pp. 363-78. 4. Hernandez-Aguilera, A., Rull, A., Rodriguez-Gallego, E., Riera-Borrull, M., Luciano-Mateo, F., Camps, J., Menendez, J. A. & Joven, J. (2013) Mitochondrial dysfunction: a basic mechanism in inflammation-related non-communicable diseases and therapeutic opportunities. Mediators Inflamm, 2013pp. 135698. 5. Meramat, A., Rajab, N. F., Shahar, S. & Sharif, R. (2015) Cognitive impairment, genomic instability and trace elements. J Nutr Health Aging, 19(1) pp. 48-57. 25. Lund BO, Miller DM, Woods JS (1993) Studies on Hg(II)-induced H2O2 formation and oxidative stress in vivo and in vitro in rat kidney mitochondria.BiochemPharmacol 45: 2017-2024. 26. Shenker BJ, Guo TL, Shapiro IM (1998) Low-level methylmercury exposure causes human T-cells to undergo apoptosis: evidence of mitochondrial dysfunction.Environ Res 77: 149-159. Stensvold, C., Christiansen, D., Olsen, K., & Nielsen, H. (2011). Blastocystis sp. Subtype 4 is Common in Danish Blastocystis-Positive Patients Presenting with Acute Diarrhea American Journal of Tropical Medicine and Hygiene, 84 (6), 883-885 DOI: 10.4269/ajtmh.2011.11-0005. 47. Rissanen T, Voutilainen S, Nyyssonen K, Lakka TA, Salonen JT (2000) Fish oil-derived fatty acids, docosahexaenoic acid and docosapentaenoic acid, and the risk of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study. Circulation 102:2677-2679.

 

 

http://fiathreephothcrow.eklablog.com/a300-1pj-wireless-driver-download-a179254364

 

8mm distress kit hd downloads kitchen

Name: 8mm distress kit hd downloads kitchen
Category: Soft
Published: egvertalkbles1982
Language: English

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

http://starandeli.eklablog.com/odin-multi-downloader-v-4-42-a178083922

 

3ds Max Free Trial Versions. Available Features. You should also consider that 3ds Max is only available for Windows, while Maya also runs on macOS. What is more, 3ds Max is also picking up the trend to integrate procedural workflows. Specifically, it is now possible to create wood texture using a procedural node system. Luckily (here’s the but), there are fully functional 3ds Max free trial versions for you to test before you buy it. Also, if you are a student, you are eligible for an educational version that runs for three years. However, 3ds Max shines in other areas. It is famous for its powerful modeling tools that enable users to create complex geometries in a clear cut workflow. 3ds Max is a 3D modeling software classic by Autodesk. It brings all the high-end features like particle and light simulation, cloth-simulation engine to the table that video game developers, and visual effects artists need to create entertainment content. 3ds Max vs Maya. Just in case the price tag of the commercial version is out of your budget, check out the best free 3ds Max alternatives. 2019 3ds Max Free Download: Is There a Free Full Version? Many people rightly wonder why Autodesk offers two 3D modeling softwares. As usual, the devil is in the detail. So, how does 3ds Max compare to Maya? That largely depends on your own set of skills as a 3D artist. Full Version. Another selling point are Maya’s 3D animation tools. Character rigging and animation are famously robust. Therefore, this 3D animation software is one of the go-to suites in the games and effects industries. Maya boasts its own scripting language MEL that is a huge favorite among professionals in the effects industry. They love MEL, as it allows them to create bespoke tools for their projects that can speed up the workflow of repetitive tasks and thus accelerate the overall turnaround. Its vast feature set makes 3ds Max an industry standard. As such, it is used by diverse groups of professionals like architects, engineers, game developers, and VFX artists. Hence, it comes as no surprise that the full version of 3ds Max is not free. Regarding 3D modeling itself, 3ds Max is capable of creating parametric and organic objects using polygons, subdivision surfaces, and spline-based modeling. 3ds Max is a commercial software used for 3D modeling and 3D animation. It is famous for its powerful modeling tools that enable users to create complex geometries in a clear cut workflow. In addition, some professionals consider it easier to learn than Maya, the other 3D modeling software by Autodesk. The newest release of 3ds Max offers support for the Open Shading Language (OSL). This effectively extends the range of possibilities for physically-based renderers (like Arnold) inside 3ds Max that support ray tracing and global illumination. Designers will be interested in the NURBS-based modeling tools in this 3D modeling software that allows for both organic and mathematically precise meshes. Among the other techniques is the ability to create models from point cloud data. Also, 3ds Max is beloved by architects and engineers because it is designed to interface with CAD tools like AutoCAD. This makes it the go-to solution for high-quality architectural visualizations. Click SIGN IN to use your existing Autodesk account, or click CREATE ACCOUNT to create a new account. Enter the required information on your educational institution and select your field of study. You can now access the Autodesk Education Community. Select the desired version, your operating system, and your preferred language. The displayed serial number and product key are sent to your email address. Click BROWSER DOWNLOAD. Install the free version of 3ds Max. When installing the 3D modeling software the first time, enter the serial number and product key to unlock it. When you start 3ds Max the first time, activate the license. The correct answer to the question if there is a full free version of 3ds Max would be “Yes, but …” or “No, but …” depending on your point of view. Autodesk offers educational licenses of 3ds Max that are valid for three years. They are available on Autodesk’s website. Click DOWNLOAD FOR FREE. Read the system requirements notice. Click NEXT. Choose “Individual or Business User” from the list. Choose your language. Click NEXT. Enter your personal information to create an Autodesk account. Alternatively, sign in to your existing Autodesk account. Read the Trial Notice and click BEGIN DOWNLOAD. Install, and start using the free trial of 3ds Max. Interested users can get a free one-month trial version from Autodesk’s website. The process is refreshingly straightforward: A big chunk of 3ds Max’s audience is made up of graphic artists and designers who leverage the 3D modeling software’s strengths in this field. In addition, some professionals consider it easier to learn than Maya. Looking for "3ds Max free download" and don't want to commit to buy the full version of the popular 3D modeling software? Here are the best answers to the question: Is there a free full version? Educational Version.

 

 

http://rietolittta.eklablog.com/84a-yf-5-a-0525-download-karaoke-a179199302

 

act a fool mp3 download

Name: act a fool mp3 download
Category: Downloads
Published: teisilica1973
Language: English

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

http://fuselinow.eklablog.com/download-road-warrior-a179279874

 

License: Freeware Cost: $0.00 USD Size: 118.0 MB. License: Freeware Cost: $0.00 USD Size: 5.4 MB. More Info Download. License: Freeware Cost: $0.00 USD Size: 41.0 KB. Platforms: Windows Similar: The Cloud Notes sidebar gadget will allow you to store, access and share sticky notes. Platforms: Windows Similar: More Info Download. An optional component, cloud drive network accelerator, improves the performance and availability of your data. License: Freeware Cost: $0.00 USD Size: 5.4 MB. More Info Download. Generate Web, Mobile and Cloud applications in record time, straight from your database with Iron Speed Designer. Quickly create visually stunning, feature-rich apps that are easy to customize and ready to deploy. License: Freeware Cost: $0.00 USD Size: 129.5 MB. Gazelle Lite is the entry version of our advanced multi-staff, multi-terminal, multi-branch POS (point of sale) product Gazelle. Gladinet Cloud Desktop provides seamless desktop access to cloud storage from Amazon, Google, and many other providers. Platforms: Windows Similar: More Info Download. License: Freeware Cost: $0.00 USD Size: 1.8 MB. Platforms: Windows Similar: More Info Download. Gazelle Lite is the entry version of our advanced multi-staff, multi-terminal, multi-branch POS (point of sale) product Gazelle. More Info Download. Platforms: Windows Similar: License: Freeware Cost: $0.00 USD Size: 24.8 MB. 100% free cloud hotel management system with Windows and web-based interfaces that encompasses all aspects of the hotel, from taking reservations and check in/check out to billing and tax reports. A rich set of reports covers all hotel's operations. More Info Download. License: Freeware Cost: $0.00 USD Size: 2.3 MB. Cloud Data Backup is the safest tool that sends a copy of your confidential files (audio-video files, photos, office documents, emails, etc) over the internet and encrypts the vital files that cannot be misused by any unauthenticated users. More Info Download. Encryption software for on-line drives, like Dropbox or Google Drive, Network drives (NAS), and external drive. Secured Cloud Drive encrypts files before they are uploaded to the Cloud. Free for personal use. It works with any cloud storage provider. License: Freeware Cost: $0.00 USD Size: 417.7 MB. More Info Download. Platforms: Windows Similar: License: Freeware Cost: $0.00 USD Size: 2.6 KB. More Info Download. More Info Download. Freeware point cloud to nurbs. Platforms: Windows Similar: License: Freeware Cost: $0.00 USD Size: 58.6 MB. More Info Download. Provide zoom and scroll functions during Power Point presentation. License: Freeware Cost: $0.00 USD Size: 1.5 MB. Panda Cloud Cleaner is an advanced disinfector based on Collective Intelligence (scanning in-the-cloud) that detects malware that traditional security solutions cannot detect. License: Freeware Cost: $0.00 USD Size: 1.3 MB. Cloud Control Toolkit is the reliable software that supports all Windows platforms and able to control all the operations of devices such as PCs, laptops, Android phones, iPones, Tablets, etc from remote place. More Info Download. Platforms: Windows Similar: License: Freeware Cost: $0.00 USD Size: 15.6 MB. Platforms: Windows Similar: 100% free cloud retail management system with Windows and web-based interfaces that encompasses all aspects of the retail: taking orders, billing, purchasing, inventory and labour management. A rich set of reports covers all retail operations. Point of Success software has been chosen by thousands of restaurants for its combination of of useful features and low price. More Info Download. More Info Download. License: Freeware Cost: $0.00 USD Size: 57.7 MB. Open source 3D rendering solution adhering to the RenderMan standard Aqsis is a cross-platform photorealistic 3D rendering solution, adhering to the RenderMan interface standard defined by Pixar Animation Studios. Platforms: Windows Similar: More Info Download. Platforms: Windows Similar: Platforms: Windows Similar: More Info Download. More Info Download. More Info Download. Platforms: Windows Similar: Cloud Explorer is a free software that lets you easily access all of your content in cloud storage service such as Dropbox, Google Drive and SkyDrive. License: Freeware Cost: $0.00 USD Size: 18.0 MB. More Info Download. Platforms: Windows Similar: Platforms: Windows Similar: License: Freeware Cost: $0.00 USD Size: 5.6 MB. Platforms: Windows Similar: GOM Inspect - Powerful, free software for inspection and mesh processing GOM Inspect is a free 3D inspection and mesh processing software for dimensional analysis of 3D point clouds and viewer for ATOS and GOM Inspect Professional data sets. License: Freeware Cost: $0.00 USD Size: 90.0 KB. Platforms: Windows Similar: Platforms: Windows Similar: Create slide shows with a fractal transition effect with the Cloud Text Applet. License: Freeware Cost: $0.00 USD Size: 5.5 MB. 100% free cloud restaurant management system with Windows and web-based interfaces that encompasses all aspects of the restaurant, from taking orders to billing and tax reports. A rich set of reports covers all restaurant operations and life cycles. Platforms: Windows Similar: Cloud Drive Optimiser 64-bit, improves performance, reduces bandwidth and reduces your data storage requirements.

 

 

http://tirurandho.eklablog.com/82801h-hd-audio-controller-driver-download-microsoft-a179266944